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Biomedical subjects

P MacPherson

Publications and source records attributed to P MacPherson.

44 records · Page 3Linked to original sources
PubMed1985

Ultrastructure of cerebral arteries following experimental subarachnoid haemorrhage.

Scanning and transmission electron microscopy have been used to examine the ultrastructure of cerebral arteries taken from dogs up to nine days following the injection of autologous blood into the suprachiasmatic cistern and using meticulous perfusion-fixation technique. No ultrastructural changes in the cerebral arteries were noted either at sites of radiologically demonstrated arterial constriction or elsewhere. The only abnormality noted was the presence of some leucocytes and macrophages in the subarachnoid space surrounding the arteries. These results are discussed in relation to changes in cerebrovascular reactivity that occur at this stage following subarachnoid haemorrhage.

Animals↗
PubMed1983

Plasma protein-binding and CSF concentrations of valproic acid in man following acute oral dosing.

Simultaneous cerebrospinal fluid (CSF), total and free plasma valproic acid (VPA) concentrations were measured in 17 patients receiving two weight-adjusted VPA doses as seizure prophylaxis prior to diagnostic myelography or cisternography. Free drug concentrations were similar when measured by equilibrium dialysis (ED) at 37 degrees C for 24 h (Dianorm) or by a novel ultrafiltration (UF) method (EMIT freelevel system 1, SYVA) (ED:2.3-35.5 mg-1; UF:1.3-33.6 mg-1; r = 0.78, P less than 0.002). There was wide variation in total VPA concentration (39-154 mg-1) and in free fraction (ED: 3.3-25.6%; UF: 5.9-24%). Concentration dependent protein binding was not demonstrated. CSF VPA varied between 4.2 and 25.6 mg-1 and was accurately reflected by free plasma VPA concentrations (ED: r = 0.75, P less than 0.005: UF: r = 0.93, P less than 0.001). CSF concentration also correlated with the total plasma VPA (r = 0.76, P less than 0.005). The Emit freelevel system 1 provides a rapid measure of unbound VPA in the plasma which may be suitable for routine clinical use.

Adolescent↗
PubMed1982

Computed tomography of intracranial lymphoma.

The appearances on computed tomography (CT) of 17 patients with histologically proven intracranial lymphoma have been analysed and abnormalities detected in 16. Four of the patients had systemic lymphoma. Multiple lesions were seen in eight patients (47%), in six of whom the multiple lesions in each patient were of similar appearance. There was good macroscopic correlation between the CT and post-mortem appearances in the eight patients who subsequently died, although in five, histological examination showed more extensive infiltration. Meningeal involvement was seen more commonly in the cases of systemic lymphoma than in the purely cerebral lymphomas, but parenchymal lesions were equally common in both. Grey matter lesions tended to be clearly demarcated, of increased density with little oedema or displacement; homogeneous density enhancement was produced by the intravenous injection of contrast medium. White matter lesions were usually poorly demarcated, of variable density with marked oedema and displacement, and with heterogeneous enhancement.

Adult↗