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P Mainguet

Publications and source records attributed to P Mainguet.

At least 19 recordsLinked to original sources
PubMed1992

Cytology: a simple, rapid, sensitive method in the diagnosis of Helicobacter pylori.

Cytology and the rapid urease test on gastric biopsies may diagnose Helicobacter pylori (H. pylori) infection within an hour. We evaluated the sensitivity and reproducibility of touch cytology (imprints from biopsies). In 19 patients with duodenal ulcer, biopsies were obtained from the antrum, fundus, and bulb. H. pylori was diagnosed in 42 sites on smears: 28 by culture and 23 by histology. H. pylori was present in the antrum and fundus in 16 and in the bulb in 11. Assessment of paired antral biopsies in 29 additional patients with or without touch cytology (imprints) before specimens were sent for histology or culture revealed no difference for the presence of H. pylori. A second reading of the 58 smears by a second observer revealed agreement on the presence or absence of H. pylori in 53 (91%). In conclusion, touch cytology is a simple rapid, sensitive, and reproducible diagnostic method for H. pylori that does not alter the quality of biopsies for subsequent culture or histologic examination. For the first time, diagnostic methods have been compared on the same biopsies, eliminating sampling variation.

Biopsy↗
PubMed1991

Ménétrier's disease with lymphocytic gastritis: an unusual association with possible pathogenic implications.

Ménétrier's disease is a rare form of hypertrophic or hyperplastic gastropathy, characterized by conspicuous thickening of the gastric mucosal folds and foveolar (crypt) hyperplasia. The pathogenesis of Ménétrier's disease remains unresolved. Lymphocytic gastritis is a newly described entity which corresponds endoscopically to varioliform gastritis and is marked by T-lymphocyte infiltration of the surface epithelium and crypts. Five surgical cases and one autopsy case combining the gross and microscopic features of Ménétrier's disease and lymphocytic gastritis are presented. This unusual and hitherto previously undescribed association raises the possibility of a common pathogenesis for Ménétrier's disease and lymphocytic gastritis.

Adult↗
PubMed1991

Quantification of Helicobacter pylori infection in gastritis and ulcer disease using a simple and rapid carbon-14-urea breath test.

Gastric urease was studied isotopically in 230 patients with biopsy-proven normal mucosa or chronic gastritis, including 59 patients with ulcer disease. Carbon-14-urea was given in 25 ml of water without substrate carrier or nutrient-dense meal, and breath samples were collected over a 60-min period. The amount of 14CO2 excreted at 10 min was independent of the rate of gastric emptying and was not quantitatively influenced by the buccal urease activity. The 10-min 14CO2 values discriminated well between Helicobacter pylori positive and negative patients (94% sensitivity, 89% specificity) and correlated with the number of organisms assessed by histology. The test was a good predictor of chronic gastritis (95% sensitivity and 96% specificity), and a quantitative relationship was observed between 14CO2 values and the severity and activity of the gastritis. In H. pylori positive patients, breath 14CO2 was found to be similar in patients with and without ulcer disease, suggesting that the number of bacteria is not a determining factor for the onset of ulceration.

Breath Tests↗
PubMed1990

Comparison of anti-Helicobacter (Campylobacter) pylori IgG antibodies between different areas of Belgium.

We have collected sera from 4053 patients of different parts of Belgium. Sera were randomly selected whatever the kind of pathology. Anti-Helicobacter (Campylobacter) pylori IgG were determined with an ELISA technique using whole formalized bacteria. The results suggest that the mean antibody titres differ between various areas, with an overall higher prevalence in the north-western part of the country.

Adult↗
PubMed1990

Lymphocytic gastritis--prospective study of its relationship with varioliform gastritis.

Lymphocytic gastritis is a new histopathological entity characterised by a dense lymphocytic infiltration of surface and pit gastric epithelium. Previous retrospective work has suggested that lymphocytic gastritis is related to an endoscopic form of gastropathy comprising enlarged folds, nodules and erosions, commonly denoted as varioliform gastritis. In the present prospective study, the relationship is clearly shown; nearly 82% (54/66) of the varioliform gastritis observed in four different endoscopy units correspond histologically to lymphocytic gastritis. The correlation is even better if cases showing strictly antral localisation are excluded (53/55) - that is, more than 96%. The histological concept of lymphocytic gastritis seems, however, to extend beyond varioliform gastritis as of 67 cases of lymphocytic gastritis diagnosed during the period under study, one third had no particular endoscopic expression.

Adolescent↗
PubMed1989

Lymphocytic gastritis versus varioliform gastritis. A historical series revisited.

A historical series of varioliform gastritis published in 1978 by Lambert et al. (Digestion 1978; 17: 159-167) was revisited by two pathologists. The histological preparations from 35 patients were reread and interpreted in the light of endoscopic data found in the files. The results demonstrate a strict correlation between clinical diffuse varioliform gastritis and a recently recognized histopathological entity--lymphocytic gastritis, which is characterized by intense lymphocytic infiltration of the surface and foveolar epithelium. The rare discrepancies occur in Crohn's disease and in varioliform gastritis limited to part of the stomach, mostly the antrum.

Crohn Disease↗
PubMed1988

Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study.

Lymphocytic gastritis is a histopathological entity characterised by the accumulation of small lymphocytes in the surface and foveolar epithelium. In order to investigate the correlation between endoscopy and histology in this condition, 192 observations selected on the basis of a presumed diagnosis of erosive or varioliform gastritis were reviewed. Ninety two instances corresponded to lymphocytic gastritis, while 100 did not show any particular microscopic feature and were labelled non-specific gastritis. There was a good correlation (48 of 58) between the diagnosis of the so-called varioliform gastritis and the histological evidence of lymphocytic gastritis. The correlation was even better when nodules, erosions, and enlarged folds were considered. Lymphocytic gastritis has a typical endoscopical appearance consisting of nodules, erosions, and large folds predominating in the gastric body. This contrasts with non-specific gastritis, which affects the antrum and produces erosions on a flat mucosa.

Duodenum↗
PubMed1987

[Evaluation of per-endoscopic cytology in the identification of Campylobacter pylori on gastric mucosa].

The presence of Campylobacter pylori on gastric mucosa was evaluated by touch cytology of gastric biopsies in a series of 100 patients. Results were compared to biopsy cultures. Of 43 culture-positive patients, cytology was positive in 37 (86 p. 100). Cytology was positive in 16 of 57 culture-negative patients, who had peptic ulcer and/or gastritis on biopsy, conditions widely associated with the presence of Campylobacter pylori. Cytologic examination, yielding quick results, is thus a sensitive diagnostic method for Campylobacter pylori. In addition, retrospective studies of previous specimens are possible: among 11 patients with a follow up of more than one year, three of the four Campylobacter pylori carriers subsequently developed an ulcer.

Bacteriological Techniques↗