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P Marangione

Publications and source records attributed to P Marangione.

4 recordsLinked to original sources
PubMed2000

[The "guaranteed volume" in pressure support ventilation reduces the risk of barotrauma in premature children with severe respiratory syndrome].

Chronic Lung Disease (CLD) remains a major complication of prematurity, and barovolutrauma is thought to be one of the most important predisposing factors. In view of reducing the damage due to variability of tidal volume (Vt), we studied the application of the new option of volume guarantee (VG). We analyzed ventilatory data of 25 preterm infants with respiratory distress syndrome (RDS) in two situations: pressure support ventilation (PSV) + VG vs PSV alone. Data collected showed application of significantly lower peak inspiratory pressure (p < 0.001) and mean airway pressure (p < 0.001) with the constant Vt. We conclude that this ventilatory strategy, by reducing the barotrauma, could be considered a protective ventilation.

Barotrauma↗
PubMedDate not supplied

Treatment of respiratory tract infections in children: a study of a combination of amoxycillin and clavulanic acid.

In an open study, 70 in-patients and 23 out-patients aged between 1 and 14 years with sinusitis (n = 1), perforated otitis media (n = 4), pharyngotonsillitis (n = 25), tracheobronchitis (n = 30) or broncho-pneumonia (n = 33) were treated daily with a combination of 40 mg/kg amoxycillin and 10 mg/kg clavulanic acid in three equal doses for between 6 and 15 days. Purulent specimens were cultured when obtainable and pathogenic organisms identified were Staphylococcus aureus, beta-haemolytic streptococcal group A, Pseudomonas aeruginosa, Pseudococcus species and Klebsiella pneumoniae infections, of which 45.7% were beta-lactamase-producing and 54.3% were ampicillin-susceptible. After treatment, only one beta-lactamase-producing Streptococcus and one Staphylococcus infection persisted. Side-effects (vomiting, nausea, diarrhoea, maculopapular exanthema, rash) occurred in 16 patients and treatment was withdrawn in eight. It is concluded that the amoxycillin--clavulanic acid combination is a suitable first choice for the treatment of respiratory tract infections in children in whom the pathogenic organism may not have been established.

Adolescent↗
PubMedDate not supplied

Correlations between volume delivery (VTHF) in course of high frequency oscillatory ventilation (HFOV) and severity of respiratory distress.

The treatment of severe respiratory distress in infants (e.g. respiratory distress syndrome--RDS, meconium aspiration syndrome--MAS and pulmonary haemorrage) with HFOV can cause sometimes a volume delivery (VTHF) exceeding the anatomical dead space, with the possibility of an increased risk of volutrauma, implicated in the pathogenesis of chronic lung disease (CLD). The authors examined the possible correlations between VTHF and the severity of respiratory distress in order to limit the risk of ventilator-induced lung injury (VILI). Thirty-five infants in HFOV because of respiratory distress were studied. The median VTHF registered was 2.25 ml/Kg (range: 1.3-3.4) with a significant correlation to some parameters espression of severity of the respiratory distress: arterial/Alveolar ratio (a/AO2) (r = 0.519), oxygen index (OI) (r = 0.512) and mean airway pressure (MAP) (r = 0.543).

Chronic Disease↗