PubMed Health⌕ Search

Biomedical subjects

P Margosian

Publications and source records attributed to P Margosian.

5 recordsLinked to original sources
PubMed2001

Does the "keyhole" technique improve spatial resolution in MRI perfusion measurements? A study in volunteers.

We examined the potential of the 'keyhole' technique to improve spatial resolution in perfusion-weighted MRI on whole-body imagers with standard gradient hardware. We examined 15 healthy volunteers. We acquired a high-resolution image with 256 phase-encoding steps before a bolus-tracking procedure. For the dynamic series we collected only 34 lines in the center of k-space. Data reconstruction was performed by both zero-filling and keyhole methods. The dynamic datasets, concentration-time curves calculated from user-defined regions and maps of the cerebrovascular parameters using both reconstruction methods were compared. Using keyhole series, anatomical structures could easily be defined which were not seen on the original dynamic series because of blurring due to ringing artefacts. Comparison of signal-time curves in large regions yielded no significant difference in signal loss during bolus passage. In the parameter maps truncation artefacts were significantly reduced using keyhole reconstruction. The keyhole method is appropriate for enhancing image quality in perfusion-weighted imaging on standard imagers without sacrificing time resolution or information about transitory susceptibility changes. However, it should be applied carefully, because the spatial resolution of the dynamic signal change and the cerebrovascular parameters is less than that afforded by the spatial resolution of the reconstructed images.

Brain↗
PubMed2001

Multiple contrast fast spin-echo approach to black-blood intracranial MRA: use of complementary and supplementary information.

Black-blood magnetic resonance angiography (black-blood MRA) could be considered an alternative to time-of-flight (TOF) MRA. In the cases of irregular flow conditions, it could be more advantageous than time-of-flight (TOF) MRA in providing vessel definition and delineation. Proton-density weighted (PDW) multi-slab three-dimensional fast spin-echo (3DFSE) sequences have been used to generate black-blood MRA. Unfortunately, multi-planar reformatted 3DFSE images often exhibit slab boundary artifacts (intensity variation in the slice direction) which create dark bands interfering with the identification of dark blood vessels. Furthermore, PDW measurements fail to darken slow flowing or re-circulating blood in some circumstances. In this work, a dual-contrast multi-slab 3DFSE acquisition is used to approach black-blood MRA. This sequence simultaneously provides proton-density weighted (PDW) and T(2)-weighted (T2W) images which can be further integrated together to produce black-blood angiograms gained by utilizing complementary contrast and supplementary vascular information. Additionally, a technique of suppressing slab boundary artifact has been incorporated into this sequence. This approach provides: i) good SNR measurement of anatomy for the PDW image and optimal black-blood angiograms from the T2W image; ii) scan time efficiency (dual-contrast image sets plus black-blood angiograms within one acquisition); and iii) suppressed slab boundary artifacts as well as minimized mis-registration error.

Algorithms↗
PubMed1994

MR angiography of occlusive disease of the arteries in the head and neck: current concepts.

MR angiography has many applications in the evaluation of cerebrovascular disease (aneurysm, vascular malformation, neoplasm, arterial and venous occlusive disease) [1]. Of these, the most common application may be in the assessment of arterial occlusive disease in patients at risk for stroke [2]. Consequently, the accuracy of MR angiography vs conventional angiography in this assessment will most likely determine the extent to which MR angiography is routinely used in clinical practice. In this paper, we review the results of clinical trials in which MR angiography has been used to evaluate arterial occlusive disease in the head and neck and describe those recent developments that promise improved visualization of the vasculature.

Arterial Occlusive Diseases↗
PubMedDate not supplied

Prospectively gated cardiac computed tomography.

A fourth-generation scanner has been modified to perform prospectively gated cardiac computed tomography (CT). A computer program monitors the electrocardiogram (ECG) and predicts when to initiate the next scan in a gated series in order to acquire all projection data for a desired phase of the heart cycle. The system has been tested with dogs and has produced cross-sectional images of all phases of the cardiac cycle. Eight to ten scans per series were sufficient to obtain reproducible images of each transverse section in the end-diastolic and end-systolic phases. The radiation dose to the skin was approximately 1.4 cGy per scan. The prospectively gated system is more than twice as efficient as a retrospectively gated system in obtaining complete angular projection data for a 10% heart cycle window. A temporal smoothing technique to suppress reconstruction artifacts due to sorting inconsistent projection data was developed and evaluated. Image noise was reduced by averaging together any overlapping projection data. Prospectively gated cardiac CT has also been used to demonstrate that the error in attenuation measured with a single nongated CT scan through the heart can be as large as 50-60 CT numbers outside the heart in the lung field.

Animals↗