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Biomedical subjects

P Marion

Publications and source records attributed to P Marion.

At least 19 recordsLinked to original sources
PubMed1986

Characterization of tissue amyloid by immunofluorescence microscopy.

Immunohistochemical classification of amyloid type was possible in 44 of 50 (88%) patients as judged by the concordance of immunofluorescence, clinical, serum, and urine immunoelectrophoresis, and bone marrow data. In frozen tissue sections incubated with a panel of antisera monospecific for immunoglobulin heavy chains, kappa and lambda light chains, and amyloid-A-related protein, the amyloid was classified as AL in 20 and AA in 24. In 6 patients the amyloid could not be classified because of the absence of reactivity in 2 and overlap staining in 4. The findings indicate that routine immunofluorescence examination of diagnostic biopsies is an important adjunct in the classification of amyloid.

Adult↗
PubMed1986

Auditory field reduction in human following head trauma.

We measured the tonal auditory threshold for 500, 2000 and 4000 Hz, and made BAER recordings for both ears with unfiltered 125 dB SPL clicks, with 40 subjects between 18 and 23 years of age, 20 subjects having suffered minor cranial trauma during the preceding 48 hours and 20 being control subjects matched for age and sex. Compared to the control group, trauma patients showed a significantly higher auditory threshold: 19 dB SPL at 500 Hz, 9 dB SPL at 2000 and 4000 Hz. This threshold rise was bilateral. The head trauma patients showed, on average, one significantly earlier BAER wave I than did controls. This alteration was likewise bilateral. The latencies of waves II, III and V, the I-III, III-V, and I-V intervals, and the interaural wave latency and interval differences are comparable for trauma patients and control subjects. One to eight months after cranial trauma, 7 subjects manifested one sign of the subjective cranial trauma syndrome. Auditory threshold and BAER wave I earliness were not any greater for these subjects. Trauma patients seemed to show a reduction of the auditory field. They were hypersensitive to high stimulus intensities (shortening of BAER wave I) and less sensitive to low intensities (rise in tonal auditory threshold). This auditory alteration was bilateral. It can thus be thought that the trauma acts on the central nervous system to affect the operation of the cochlea via efferent pathways.

Adolescent↗
PubMed1979

[Role of intra-aortic balloon pumping in coronary surgery for stenosis of the left common coronary trunk].

Surgical treatment for stenosis of the left main coronary artery is associated with a high risk related to particular vulnerability to acute myocardial ischaemia during the period of induction of anaesthesia. Eight cases of stenosis of the left main coronary artery undergoing surgery with preoperative insertion of an intra-aortic counter-pressure balloon are reported here. The results - eight successes - as opposed to four failures seen prior to the use of this technique and in similar cases, leads the authors to suggest stenoses of the left main coronary artery as a further criterion indicating the need for routine preoperative intra-aortic counter-pressure

Aged↗