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P Marko

Publications and source records attributed to P Marko.

At least 19 recordsLinked to original sources
PubMed2000

[Value of the Valsalva maneuver for evaluating systole heart function].

Many tests and examinations are used for diagnosing heart failure. Their accuracy tends to vary, echocardiography representing the gold standard. The Valsalva maneuver involves an easy-to-perform test for assessing the cardiac ejection fraction. The present study investigated the power of the Valsalva test in patients who received an echocardiography for various indications. A total of 153 patients were examined, some recruited from private practices, some from different hospitals. An echocardiographically measured left-ventricular ejection fraction of 45% was set as the limit value. 30 patients had an ejection fraction of less than 45%, signaling a relevant systolic dysfunction. The sensitivity of the Valsalva test for detecting impaired function was 70% and its specificity 72%. The positive predictive value was 39% and the negative predictive value 90%. This means that when the Valsalva test produces a normal result and the EKG is also normal, the likelihood that the patient has no relevant systolic dysfunction is very great. The Valsalva test is cost-effective, quick and easy to perform and useful for evaluating left-ventricular pump function.

Adolescent↗
PubMed1998

Dietary influence on the urinary excretion of polyamines.

The amino groups of amino acids, the constituents of proteins, are catabolized in the urea cycle. One intermediate of this cycle, ornithine, is a precursor molecule of polyamines. The influence of dietary protein intake on the production and excretion of polyamines in the urine is yet unclear. The aim of this study was to investigate the excretion of polyamines in the urine following three days of creatine-free, creatine-free and low-polyamine diet in four persons. On the fourth day they were loaded with creatine-free, creatinine-free and low-polyamine high-protein diet (80 g/70 kg body weight). High-protein diet resulted in no increase of urinary polyamine excretion. The low-polyamine diet caused a non-significant decrease in urinary polyamine excretion (by 15%).

Adult↗
PubMed1992

[Oral anticoagulants in clinical practice].

Oral anticoagulation (OA) in ambulatory practice is a controversial issue, and the efficacy and safety of its performance is an essential condition for the use of such sophisticated therapy in this setting. The efficacy and use of OA was studied in 24 participating practices over one year (1.4 1987 to 31.3. 1988). Overall, 538 patients were treated by OA, accounting for 22.4 patients/medical practice. OA was initiated in 207 patients, while 287 patients were on longterm (greater than 2 years) anticoagulation therapy. Most patients had polymorbidity, and many presented several indications for OA. On average, thromboplastin time was determined 2.7 times in the first 2 weeks of therapy and every 21 days during the whole period. 72% of measured thromboplastin times were within the target and 90.6% within the therapeutic range. Bleeding complications occurred in 38 patients (7.6%; 11.6/100 treatment years). OA had to be interrupted only 14 times (2.6%; 4.3/100 treatment years), and 7 patients (2.3%; 2.3/100 treatment years) were admitted to hospital. 6 patients died, as compared with 7.5 deaths expected from national mortality rates; none died from complications of OA. Based on these results it can be concluded that OA was highly effective in the 24 participating practices and had a low rate of complications.

Adult↗