PubMed Health⌕ Search

Biomedical subjects

P Masi

Publications and source records attributed to P Masi.

12 recordsLinked to original sources

[Clinical and therapeutic experience during two years at the "Consultation Center" for the study of menopausal and postmenopausal problems established at the USL 19 in East Bologna].

The authors analyse two years' activities at the outpatient clinic set up for the prevention of menopause-related disorders at Mazzacorati Family Planning Clinic (USL 29-Bologna). They emphasise the fact that menopause is characterised by a complex interaction of biological, psychic and socio-cultural aspects with the result that requests for consultancy are extremely varied and sometimes, at least apparently, even contradictory. From these findings it emerges that in a sample of 440 women attending the centre, 28% requested information sessions and a further 10% expressed the need for a discussion focused on sexual problems. Moreover, while "hormone" therapy is currently positively accepted by the majority of women, the percentage of women refusing or suspending treatment is not negligible. It is worth recalling that 38% of women in pre-menopause, albeit strongly motivated to use an oral contraceptive, did not start treatment or suspended it within the first 6 months, although no collateral effects were reported, and 24% of women in spontaneous postmenopause did not commence hormone replacement therapy or suspended it in spite of having reached an acceptable level of wellbeing.

Adult↗

Mechanical stability and diffusional resistance of a polymeric gel used for biocatalyst immobilization.

The mechanical strength of gelatin gels insolubilized by crosslinking with formaldehyde was measured at various gelatin percentages and formaldehyde-to-gelatin ratios. This property was shown to be related to the characteristic sponge-like structure of the insolubilized gelatin gel, a structure that unexpectedly is also responsible for the resistance to substrate and product diffusion. A comparison between immobilizates of invertase and invertase-active yeast cells prepared with different gelatin concentrations showed that the enzyme, in contrast to cells, is deeply involved in the gel insolubilization process. The catalytic behavior of agar, kappa-carrageenan, alginate, and gelatin immobilizates was compared under the same conditions of cell loading.

Catalysis↗

4-Demethoxy-4-alkoxydaunorubicins.

The synthesis and the antitumor activities of a group of 4-demethoxy-4-alkoxydaunorubicins (VIII) are reported. The new compounds were found to have an activity equal or superior to that of daunorubicin, at somewhat higher doses.

Animals↗

Doxorubicin 14-ethers.

The synthesis and the antitumor activities of a group of doxorubicin (adriamycin) 14-ethers are reported. The new compounds were found to have an activity similar to that of daunorubicin, at somewhat higher doses, but inferior to that of doxorubicin.

Animals↗

Preparation and biological evaluation of 4-O-demethyldaunorubicin (carminomycin I) and of its 13-dihydro derivative.

A mutant strain of Streptomyces peucetius produced an anthracycline antibiotic whose structure has been established to be 4-O-demethyl-13-dihydrodaunorubicin (4), by application of spectroscopic methods and chemical degradation. A new synthesis of 4-O-demethyl-daunorubicin (carminomycin I, 2) starting from daunomycinone, together with the comparison of the antitumor activity of the anthracycline glycosides 2 and 4 are also reported.

Animals↗