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P Mathevet

Publications and source records attributed to P Mathevet.

24 records · Page 2Linked to original sources
PubMed1993

[Pulmonary metastases from a hormone-induced clear cell adenocarcinoma of the vagina].

The authors report the case of a patient aged 27 suffering from a clear cell adenocarcinoma of the vagina which was related to her mother taking Diethylstilboestrol or Distilbene (DES) during her pregnancy. This young woman presented with pulmonary metastases for which several trials of chemotherapy ended in failure. The case raises several problems amongst which are epidemiologies of cancers induced by Diethylstilboestrol (DES), their prognosis as well as the therapeutic strategies at the time of diagnosis and the recurrences which occur as metastases.

Adenocarcinoma, Clear Cell↗
PubMedDate not supplied

Effect of radiotherapy on pelvic lymph node metastasis in cervical cancer stages IB2-IVA: a retrospective analysis of two comparative series.

Efficiency of radiotherapy in controlling lymph node metastasis is a controversial issue. A continuous series of 87 patients affected by cervical cancer stages IB2-IVA and treated using pelvic radiotherapy is presented. A retrospective comparison is made between two populations. In the two populations, a staging lymphadenectomy was carried out before the onset of the therapeutic program. In the first population (53 patients), the pelvic nodes only were dissected and in the second one (34 patients), the pelvic lymph nodes were left in place and the paraaortic nodes only were dissected. In both series, a completion surgery was performed after finalization of the radiotherapy. It was carried out at open abdomen in both series. It included a systematic pelvic dissection for the patients whose pelvic nodes had been intentionally left in place at the time of the initial staging lymphadenectomy. Both series were identical as far as classic risk factors were concerned (FIGO stage, maximal tumor diameter, lymphovascular space involvement). The radiotherapy administered to the pelvis was the same in both populations. The number of patients with pelvic lymph node metastasis was 21 (39.6%) in the first population versus 6 (17.6%) in the second one (P = 0.03). The percentage of positive lymph nodes among the retrieved lymph nodes was 18.94 in the first population versus 2.8 in the second one (P = 0.0001). Pelvic radiotherapy is likely to control most of the pelvic lymph node metastasis, but not all of them. Practical deductions and further developments are discussed.

Adult↗
PubMedDate not supplied

Fatty acid composition and CD36 expression in breast adipose tissue of premenopausal and postmenopausal women.

UNLABELLED: The mammary gland is an organ under complex hormonal and developmental regulation. Among the mediators involved in this process are polypeptides, steroid hormones and certain lipids and their metabolites. The fatty acid content of the breast adipocytes is investigated because of the importance of their role in the proliferation and differentiation of the breast epithelial cells. MATERIALS AND METHODS: To address the hypothesis that polyunsaturated acid might be a risk factor for breast cancer, we examined the association between arachidonic acid (20:4n-6) and menopausal status in the women using lipid extraction from isolated human adipocytes and CD36 detection on a FACS flow cytometer. RESULTS: Compared with the related trigycerides, phospholipids in postmenopausal women contained a higher proportion of polyunsaturated fatty acids like arachidonic acid, a precursor of eicosanoids, required for many physiological roles in reproduction and implicated in the proliferation of several cell types. In order to determine the mechanisms explaining the difference in the fatty acid and long-chain fatty acid composition, we have studied the relationship between CD 36 protein and menopausal status. Menopause in women seemed to be associated with a diminuation of the amount of CD 36 protein of adipocytes (48.82 +/- 3.54% versus 20.01 +/- 0.04%) and also associated with the increased percentage of arachidonic acid observed in postmenopausal women. Our data and others led us to conclude that the variation in the composition of fatty acids can act directly on the phenomena of growth and differentiation of mammary epithelial cells and the variation in CD 36 may act either on the transport of fatty acids or on the transduction of the signal responsible for the stimulation of enzymes catalysing the conversion of arachidonic acid into different metabolites. These two phenomena could influence the risk of breast cancer in pre- and postmenopausal women.

Adipose Tissue↗