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Biomedical subjects

P Mathieu

Publications and source records attributed to P Mathieu.

At least 199 records · Page 11Linked to original sources
PubMed1981

[Prognosis of chronic post-traumatic thoracic aorta aneurysms in 15 patients (author's transl)].

False chronic post-traumatic aneurysms of the ascending aorta were detected in 15 patients. These aneurysms were false because only a few cells were present in their walls: it is only after survival for more than 3 weeks tht one can speak of chronic aneurysms, and only 5% of the injured patients survived for this period of time. The lesions show marked progression for one year, but rupture of apparently quiescent aneurysms may occur up to 20 years after the initial injury. The prognosis of these lesions is therefore comparable with that of other aortic aneurysms. Cardiovascular surgery has progressed to such an extent, and the risks are so low (0% in this series), that surgical correction should be systematically considered.

Adolescent↗
PubMed1980

[Plasma separation with membranes--examinations in man (author's transl)].

Plasma separation was carried out using a new cellullose diacetate hollow-fibre module. The pore size of the membranes used was 0.2 micrometer and the cut-off at approximately 3 million dalton. Five litres of filtrate was separated in 80 min. The protein content of the filtrate was 60% of that in the blood plasma. When plasma and filtrate were compared, there was little difference inthe proportions of the immunoglobulins. At the end of treatment, the immunoglobulin content of the plasma had been reduced to 40% of its initial concentration.

Animals↗
PubMed1980

The 4-O-methylation pathway of catecholamines: search for an in vivo production of 3-hydroxy,4-methoxyphenylglycol (iso-MHPG).

The existence of 3-hydroxy,4-methoxyphenylglycol in biological fluids has been investigated. 4-Hydroxy,3-methoxy-phenylglycol (MHPG) and 3-hydroxy,4-methoxyphenylglycol (iso-MHPG) have been separated from each other by gas-liquid chromatography of their heptafluorobutyryl derivatives, using an electron capture detector procedure. Urines of normal subjects, of patients with secreting nervous tissue tumors and human cerebrospinal fluids were analyzed. Iso-MHPG was never detected, with the exception of trace amounts in one urinary sample from a patient with a peculiarly high excretion of MHPG. It is concluded that norepinephrine is probably not 4-O-methylated in vivo, contrary to dopamine which is known to lead, at least to a small extent, to 4-O-methylated metabolites.

Chromatography, Gas↗
PubMed1978

Treatment of venous thrombosis and pulmonary embolism by streptokinase.

We applied the standard treatment with streptokinase to 52 cases of deep venous thrombosis and 35 cases pulmonary embolism. Angiography demonstrated total lysis of the clot 22 times, partial lysis 42 times, and no lysis 23 times. The absence of lysis was more frequent in venous clots than in pulmonary clots. Early treatment was more effective, achieving complete lysis in 21 of 22 cases. Nevertheless, in deep venous thrombosis, late treatment can result in partial lysis and set an important venous junction free. With the standard treatment, the biologic controls showed good lysis in 75% of the cases, insufficient lysis in 15%, and no lysis in 10%. The extent of the thrombosis is an important point. The clot was totally lysed in 9 of 10 cases of localized deep venous thrombosis. In patients with pulmonary embolism, about 30% of the obstructed surface is cleared. Nevertheless, in such cases we must take into consideration not only the nonperfused pulmonary area, but also the venous starting point of the clot.

Adult↗
PubMed1978

[Effects of intravenous trinitrine on myocardial function in left ventricular insufficiency].

The effects of intravenous trinitrin on myocardial function have been studied in 40 patients with heart failure (26 cases of coronary artery disease and 14 of apparently primary cardiomyopathy). Each patient had measurements made of left ventricular pressure, of cardiac output by the dye dilution method, of volume, of the left ventricular ejection fraction, and of the segmental parietal kinetics by means of left side ventriculography both before and after trinitrin. The following results were obtained after injection of trinitrin:--no change in rhythm and cardiac index;--an almost constant decrease in left ventricular end diastolic pressure (38 cases out of 40);--a decrease in arterial pressure and ventricular volume in about two thirds of cases;--improvement of the ejection fraction (25 cases out of 40), and of segmental parietal kinetics (26 cases out of 40) in the left ventricle. These findings were equally true in the patients with coronary artery disease and in the cardiomyopathies. In the light of these results, it appears that when used in left ventricular failure, trinitrin almost always decreases the load, but improves ventricular kinetics only in two thirds of cases, while it has no influence on cardiac output. In addition, given the difficulties in establishing a standard dose of trinitrin, the authors discuss the methods of establishing the optimal dose.

Blood Pressure↗
PubMed1978

[Streptokinase in the treatment of deep venous thrombosis and pulmonary embolism].

Fifty-two deep venous thromboses and 35 pulmonary emboli were treated by Streptokinase administered in accordance with a standard protocol. Radiological examinations revealed total lysis of clots in 22 cases, partial lysis in 42 and failure in 23. The latter more commonly involved venous clots than pulmonary emboli. Early treatment was more effective (21 total lyses out of 22) than late treatment. However, in venous thrombosis, late treatment may give partial lysis and free important venous junctions. With standard treatment, lysis was biologically correct in 70 p. 100 of cases. It was inadequate in 20 p 100 of cases and nil in 10 p. 100 of cases. The results could thus have been improved by treatment established and adjusted in the light of laboratory results. The extent of the thrombosis played an important role. Total lysis was obtained in 9 out of 10 cases of localised deep venous thrombosis. In pulmonary embolism there was an average gain of approximately 30 p. 100 in obstructed surface area. However, in these latter cases, it is important to take into account not only the pulmonary surface area obstructed but also the origin of the clots.

Adult↗