Biomedical subjects

P Mattos

Publications and source records attributed to P Mattos.

6 recordsLinked to original sources

PubMed2003

Neuropsychological assessment in HTLV-1 infection: a comparative study among TSP/HAM, asymptomatic carriers, and healthy controls.

BACKGROUND: Human T cell lymphotropic virus type 1 (HTLV-I) can cause tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) and adult T cell leukaemia/lymphoma. More recently other diseases such as isolated peripheral polyneuropathy, myopathy, artropathy, and uveitis have been associated with this retrovirus. Only a few uncontrolled studies, without necessary exclusion criteria, have described mild cognitive deficits among TSP/HAM patients. To further clarify this the authors evaluated, through neuropsychological testing patients with TSP/HAM and asymptomatic infected carriers, comparing both groups with healthy controls. OBJECTIVES: To verify the presence of cognitive deficits among TSP/HAM patients and asymptomatic HTLV-1 infected carriers. In addition, the authors aimed to investigate if these deficits correlated with the degree of motor impairment in TSP/HAM patients. METHODS: From a cohort of 501 HTLV-1 infected people the authors selected, according to predefined inclusion and exclusion criteria, 40 asymptomatic HTLV-1 carriers and 37 TSP/HAM patients. Neuropsychological testing was blindly performed in both groups and their scores were compared with those obtained from controls. RESULTS: Both the HTLV-1 carrier group and the group of patients with TSP/HAM exhibited a lower performance in neuropsychological tests when compared with controls. Asymptomatic infected carriers and TSP/HAM patients did not differ in their cognitive results. Also, there was no relation between the degree of motor disability and cognitive deficits in the TSP/HAM group. Psychomotor slowing and deficits in the some domains characterised the neuropsychological impairment in HTLV-1 infection: verbal and visual memory, attention and visuomotor abilities. CONCLUSIONS: TSP/HAM as well as asymptomatic infection can be associated with mild cognitive deficits. This finding, if confirmed by further studies, will permit the inclusion of cognitive impairment among the neurological manifestations of HTLV-1.

Adult↗

PubMed2001

[Comorbidity in children and adolescents with attention-deficit disorder: preliminary results].

Thirty-four children and adolescents with ages from 6 to 16 years having a diagnosis of attention-deficit hyperactivity disorder (ADHD)according to DSM-IV criteria were examined. Psychiatric comorbidity was evaluated through a standard questionnaire given to parents. There was a significant comorbidity (85,7%) in the sample, oppositional-defiant disorder (20,6%) and conduct disorder (39,2%) being the most common comorbid diagnosis. At least two diagnosis other than ADHD could be found in 57% of the sample. Major depression was seen in four cases and anxiety states (generalized anxiety disorder, separation anxiety and phobias) were seen in 34.3% of the sample. Comorbidity modifies prognosis in a significant way and may suggest specific therapeutic interventions according to each case. Frequent comorbidity may suggest the need for diagnostic interviews that covers other psychiatric disorders.

Adolescent↗

PubMed2000

Neuropsychological sequelae in Kleine-Levin syndrome: case report.

Kleine-Levin syndrome is characterized by periodic hypersomnia, hyperphagia, sexual disinhibitions and behavioral disturbances. The prognosis is generally benign, with normal cognitive and social functions after the episodes. We describe a typical case of Kleine-Levin syndrome associated with apparent academic decline, neuropsychological sequelae and personality alterations after the second episode of the illness. Further research in the natural history of Kleine-Levin syndrome is needed, for example, to determine whether early intervention would improve long-term prognosis.

Adolescent↗

PubMed1997

[Normalization of a computerized visual attention test (TAVIS)].

The authors present the normative data of a computerized test (TAVIS) that address visual attention in children and adolescents being the first neuropsychological instrument as such devised and developed in Brazil. Selective, alternate and sustained attention aspects are evaluated through three different tasks. Omission and action errors as well as time reaction are evaluated. The advantages and limitations of the test are commented.

Adolescent↗

PubMed1997

[Neurosurgical interventions and neuropsychological assessment. Case report].

The authors present the results from the neuropsychological examination of a boy suffering from refractory epilepsy due to a brain tumor. Cognitive deficits were subtle and were not disclosed during ordinary interview; there were few complaints also. Correlations between neuropsychological and neuroanatomical aspects are commented as well as the benefits from the neurosurgical intervention. The importance of neuropsychological testing in the setting of neurosurgical proceedings is emphasized.

Brain Neoplasms↗

PubMed1995

Citalopram, depression and pseudo dementia: a neuropsychological case study.

The author presents a case of (depressive) pseudo dementia, commenting on the clinical and neuropsychological findings before and after the use of citalopram, a serotoninergic anti depressive drug. The case portrays the current criticism about the old dichotomy between non-reversible ("functional") and reversible ("organic") dementia. The 73 year old woman initially diagnosed as pseudo demented showed some mild cognitive deterioration in neuropsychological evaluation after the improvement of her depressive symptoms. Some reasons for the divergent findings on pseudo dementia prognosis in the literature are proposed.

Aged↗