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P McBee

Publications and source records attributed to P McBee.

3 recordsLinked to original sources

Inhibition of liver metastases in nude mice by the combined action of 5-fluorouracil and interferon.

Liver metastasis in nude mice was studied using LoVo, a cell line developed from a patient with adenocarcinoma of the colon. LoVo cells injected into the spleen of 4-week-old nude mice showed 100% tumorigenicity in the spleen and metastases to the liver. This system was used to study ways in which to improve the efficacy of 5-FU, which was used in combination with alpha-2a interferon. Our results show that interferon can potentiate the effect of 5-FU in inhibiting liver metastases. Either drug given alone did not show comparable inhibition.

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