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Biomedical subjects

P McCartney

Publications and source records attributed to P McCartney.

24 records · Page 2Linked to original sources
PubMed1977

Myocardial ischaemia, risk factors and death from coronary heart-disease.

Mortality follow-up is now complete for 5 years in the 18 403 male civil servants aged 40-64 who were examined between 1967-69 in the Whitehall Study of British civil servants. During this period, 277 of them died of coronary heart-disease (C.H.D.); half of these deaths were in subjects in whom the findings at initial screening had suggested early myocardial ischaemia (angina or history of possible infarction according to standard questionnaire, or electrocardiographic evidence of ischaemia). The finding of suspect ischaemia had greater predictive power than the "primary" coronary risk factors, from which it was generally independent. At each level of the primary risk factors, the risk of death from C.H.D. was much greater in the presence of suspect ischaemia; and, with the possible exceptions of glucose tolerance and physical activity, the main risk factors still operated even at the stage of early ischaemia. These findings have implications for future studies of the effects of intervention.

Adult↗
PubMed1977

Self-administration of a questionnaire on chest pain and intermittent claudication.

A total of 18 403 men aged between 40 and 64 years took part in a screening examination which included a self-administered version of the London School of Hygiene questionnaire on chest pain and intermittent claudication. The yield of positives for "angina" and "history of possible infarction" was about twice as high as with interviewers, but the positive groups obtained by the two techniques differed little in their association with electrocardiographic findings or in their ability to predict five-year coronary mortality risk. This risk ranged from 0-9% in men negative to questionnaire and electrocardiograms (ECG), to 4-3% for those with positive ECG but no symptoms, 4-5% for those with angina and negative ECG, up to 16% for those with angina and positive ECG. The self-administered version of this questionnaire provides a simple and convenient means of identifying individuals with a high risk of major coronary heart disease.

Adult↗
PubMed1976

Smoking and other risk factors for coronary heart-disease in British civil servants.

A five-year follow-up of 18 403 male British civil servants between the age of 40 and 64, who had been the subject of an earlier clinical survey found 277 deaths from coronary heart-disease (C.H.D.). After adjusting for age, current cigarette smoking, systolic and diastolic blood-pressure, and blood-cholesterol were shown to be related to both the prevalence of one or more indices of cardiac ischaemia and to the risk of cardiac death. Neither blood-glucose two hours after a 50 g load nor weight/height showed any such simple linear association with mortality. Multivariate analysis confirmed that the main risk factors were independently related to cardiac morbidity and mortality. Irrespective of blood-pressure or plasma-cholesterol, current cigarette smokers thus had a higher risk of C.H.D. death than those not smoking cigarettes.

Adult↗