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P McGarry

Publications and source records attributed to P McGarry.

17 recordsLinked to original sources
PubMed1997

New variant Creutzfeldt-Jakob disease: psychiatric features.

BACKGROUND: An apparently new variant of Creutzfeldt-Jakob disease (CJD), new variant CJD (nvCJD), was identified in the UK in 1996. There have now been 21 cases of nvCJD in the UK and one in France. Psychiatric symptoms are prominent in the initial presentation in these cases. METHODS: Cases of nvCJD are identified mainly by direct referral from neurologists and neuropathologists. Detailed clinical information was obtained by review of case notes and interviewing patients' relatives. We report the psychiatric features of the first 14 cases on nvCJD in the UK. Psychiatric notes were examined in all 13 of these cases who were seen by a psychiatrist. RESULTS: Eight cases were women. All 14 cases had early psychiatric features and in nine, the first symptom was psychiatric. 13 cases were seen by a psychiatrist and the majority were diagnosed as suffering from depression or depression secondary to organic disease. Two cases suffered from first-rank symptoms suggestive of psychotic illness and transient delusions and auditory or visual hallucinations occurred in the majority. All cases were referred to a neurologist as the illness evolved and neurological signs developed. INTERPRETATION: Psychiatric symptoms are a consistent early clinical feature in nvCJD. Analysis of the psychiatric symptoms does not suggest specific features that readily allow distinction from more common psychiatric disorders, although the occurrence of associated persistent sensory symptoms may raise the possibility of this diagnosis. Neurological signs, including ataxia, involuntary movements and cognitive impairment developed in all cases and the evolution of increasing neurological deficits is likely to remain critical to the clinical diagnosis of nvCJD.

Adult↗
PubMed1994

Delicate longitudinal nuclear grooves in childhood ependymomas.

Nuclei of ependymal tumor cells have a pattern of delicate uniform, linear, longitudinal, excentric grooves or clefts, usually single, involving the nuclear membrane and extending at least half the nuclear diameter, producing a notched mitten-shaped nuclear outline, forming a pattern not seen in other neural tumors. Histologically, 13 of 14 childhood ependymal tumors had nuclear clefts. Using these clefts with other histologic criteria, ependymal tumors were identified at the time of surgery 11 of 11 times, with no false-positive results. Cytologically, eight of 10 ependymal and seven of 32 other brain tumors had clefts. These seven other tumors had either additional nonuniform convolutions or folds (n = 5) or had only rare clefts (n = 2). This uniform pattern of nuclear clefts may help identify poorly differentiated ependymal tumors on permanent sections and may help recognize ependymal tumors at surgery, guiding the surgeons' resection.

Brain Neoplasms↗
PubMed1990

A cluster classification for histologic diagnoses of CNS tumors in an epidemiologic study.

This paper introduces a method which was utilized to sort multiple pathologic diagnoses pertaining to brain tumors into clusters of equivalent diagnostic terms for an epidemiological study of brain cancer. The method enabled the medical record abstractors to ascertain cases for the study. It enabled the reviewing pathologist to identify differences between original and reviewed diagnoses. It identified the large range of classification systems of brain tumors used by practicing pathologists as a factor contributing to confusion of data if slide reviews are not incorporated into epidemiological studies, and demonstrated how the use of a cluster classification alleviates this problem.

Adult↗
PubMed1985

Cerebral atherosclerosis in New Orleans. Comparisons of lesions by age, sex, and race.

We compared mean extent of atherosclerotic lesions in carotid and intracranial arteries at autopsy among age, sex, and race subgroups in New Orleans. Most comparisons were made within similar broad cause-to-death categories after excluding deaths due to diseases associated with increased amount of atherosclerosis. Use of this basal group of cases reduces the effect of selection bias due to cause of death in this autopsy population. Fatty streaks were present in the carotid arteries of almost all cases even in the youngest age group (10 to 14 years) and were more extensive in blacks than in whites. Raised atherosclerotic lesions increased with age in the carotid arteries of blacks from age group 15 to 24 years and in whites from age group 25 to 34 years; black men and white men had about the same amount of raised lesions, whereas black women consistently had more than white women. In the intracranial arteries, fatty streaks and fibrous plaques began from age 15 to 24 years; blacks had more raised lesions than whites, particularly in the oldest age group, 65 to 69 years. These findings and mortality data suggest that in the 1960s and early 1970s black men and women were more susceptible to cerebral atherosclerosis and cerebrovascular diseases than white men and women.

Adolescent↗
PubMed1978

A case of primary amebic meningoencephalitis. Light and electron microscopy, and immunohistologic studies.

A 56-year-old alcoholic developed primary meningoencephalitis and died 3 weeks later. Autopsy revealed multiple areas of necrosis and acute and granulomatous inflammation in the brain and pancreas. Trophozoites and cysts were discovered in the brain and trophozoites alone in the pancreas. Morphologic studies revealed some parasitic features described as characteristic for Naegleria, but clinical, histological and immunohistological features favored in Acanthamoeba infection. This study calls for caution in the use of pure morphological criteria for the differential diagnosis of Naegleria and Acanthamoeba in humans. Cultural characteristics, immunohistology and serologic tests are probably more reliable for differentiating these parasites.

Amebiasis↗
PubMedDate not supplied

A two-year clinical evaluation of TPH for restoration of Class II carious lesions in permanent teeth.

To evaluate the clinical suitability of a barium silicate-filled composite (TPH) for restoration of posterior teeth, 50 Class II restorations were restored in 36 patients. Restorations included 22 molars and 32 premolars. Cavity preparations were protected with calcium hydroxide or a resin-modified glass ionomer cement, or both. Enamel was etched for 30 seconds with 37 percent H3PO4. All dentin surfaces were treated with a dentin bonding system that was placed, cured, and restored in 2 microns increments. The restorations were finished using diamond burs, polishing points, and paste. Evaluation periods were at zero (50 restorations), 6 months (35 restorations), 1 year (31 restorations), and 2 years (29 restorations), using the USPHS System and M-L indirect scale. At zero time, 50 restorations were scored "a" in all categories by using two independent evaluators. After 6 months, 35 restorations were graded with one "a" in postoperative sensitivity. After 1 year, 31 restorations were evaluated with one additional "b" for marginal integrity. After 2 years, 2 additional "b" for marginal integrity and 1 "b" for surface staining were noted. No "c" was observed in any categories throughout this study. Wear analysis revealed, on average, 2 microns of wear after 6 months, 7.8 microns of wear after one year, and 10.3 microns of wear after 2 years.

Adult↗