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Biomedical subjects

P McGee

Publications and source records attributed to P McGee.

16 recordsLinked to original sources
PubMed1996

Nurses' perceptions of roles in multidisciplinary teams.

The move towards multidisciplinary approaches to health care has been encouraged by a number of government reports (DoH 1986, 1989) in order to support the increase in community care and improve the quality of the service. Such approaches to care are dependent on a high level of co-operation between members of different professions within the multidisciplinary team. Inherent in the concept of such a team is the assumption that each team member has a clear understanding of the role of all other members. This project set out to test this assumption by examining the knowledge and perception of nurses and podiatrists with regard to each other's role.

Education, Nursing↗
PubMed1996

Comparison of adjuvant formulations for cytotoxic T cell induction using synthetic peptides.

We have investigated the capacity of synthetic peptides delivered in different adjuvant formulations to induce cytotoxic T lymphocyte (CTL) responses to a class I H-2Kd-restricted Plasmodium berghei circumsporozoite epitope, CS 252-260. Using three immunogen formulations: soybean emulsion; Montanide ISA720; and lipopeptide (P3-CS), we first evaluated the effects of immunization routes on CTL induction. No CTL response was induced in mice immunized s.c. or i.p. with CS peptide formulated in soybean emulsion. In contrast, immunization with lipopeptide P3-CS either s.c. or i.p. effectively primed for CTL. Interestingly, CS peptide emulsified in Montanide ISA720 induced a CTL response only when delivered s.c. and not i.p., indicating the critical influence of immunization routes on CTL induction. We then compared the effectiveness of eight adjuvant formulations to induce CTL response following a single s.c. immunization. Notably, lipopeptide P3-CS and CS peptide admixed with P3 or POE lipid molecules stimulated a vigorous CTL response. However, only mice immunized with P3-CS and CS peptide admixed with P3 molecule generated long-lived CTL which persisted in vivo for 5 months. Thus, based on a simultaneous comparison of the different adjuvant formulations, we demonstrated that the conjugated and unconjugated P3 lipopeptides were the most effective immunogens for eliciting primary and memory CTL in mice.

Amino Acid Sequence↗
PubMed1996

Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity.

Peptides from Plasmodium berghei circumsporozoite protein (CS) and influenza A virus nucleoprotein (NP) were entrapped in microparticles prepared from poly (lactide-co-glycolide) polymers, and the microparticles were administered parenterally to mice. After immunization with single or multiple doses, splenocytes were tested for a cytotoxic T cell (CTL) response and high levels of CTL activity were detected. The CTL induced were CD8+, MHC class I restricted, and could recognize virus infected cells. Peptide entrapped in microparticles of mean size < 500 nm were better inducers of CTL than larger microparticles (mean > 2 microns and above). Microparticles could also be used to deliver lipid modified peptides (lipopeptides) and elicited higher levels of cytolytic activity than either free peptide in microparticles or lipopeptide alone. Microparticles provide a novel way of inducing a CTL response using synthetic peptides.

Adjuvants, Immunologic↗
PubMed1994

Rediscovering theatre nursing.

I must begin by saying that I am not a theatre nurse. My professional background is very much in medical nursing and I did not begin to think about theatres until I became a nurse teacher. It was then I found myself helping to prepare nurses for their alloction to theatres and, later, listening to their accounts of their experiences. I have to say that theatres were not, and are still not, a highspot in pre-registration courses as far as the majority of students are concerned. As a tutor, particularly as I became more involved in the development of Project 2000, I began to ask myself why this was. What were the implications and did theatre experience really matter. During the last year I have been talking to theatre nurses in different hospitals about how they see their work and whether tutors should still be sending them students. These talks have been very informal but my objective was to tease out the nursing element of theatre work. I very much support the view that theatre nursing exists and that it can be made explicit. I must emphasise at this stage that this work is very much in its infancy and, as yet, lacks strong theoretical dimensions. Comments and contributions from readers will be very welcome.

Humans↗
PubMedDate not supplied

Defining nursing practice.

Nursing needs definition. The UKCC has recently proposed three levels of nursing practice: primary, clinical nurse specialist and advanced practitioner. This article examines these roles and illustrates the level of attainment required in relation to wound care.

Career Mobility↗
PubMedDate not supplied

Developing a model for theatre nursing.

There has been much debate about the nature of theatre work and whether the activities performed by theatre nurses represent real nursing. This article examines the potential for constructing a nursing model to depict the variety of environments in which theatre nurse's work.

Humans↗
PubMedDate not supplied

The concept of respect in nursing.

Respect is a central concept in nursing care but is not well defined. Lack of respect for patients dehumanises them and may contribute to abuse and ill treatment. Transcultural care should be based on an understanding of the concept of respect which is shared by all concerned.

Cultural Diversity↗
PubMedDate not supplied

Culturally sensitive and culturally comprehensive care.

Nursing is essentially about caring for others (Leininger, 1988) and it is this emphasis on care that distinguishes nursing from other professions, most notably medicine, which are oriented towards cure. To achieve culturally sensitive care nurses need to develop a knowledge base which incorporates an awareness of their own culture, preferences and prejudices alongside specific information about ethnic groups.

Ethnicity↗
PubMedDate not supplied

Educational issues in transcultural nursing.

Transcultural nursing education is an essential element of the nursing curriculum. There are a number of curriculum designs available but a combination of approaches seems to be the most desirable way forward.

Clinical Competence↗
PubMedDate not supplied

A survey of specialist and advanced nursing practice in England.

This report is the result of a 1-year research project which aimed to develop a contemporary account of the expectations of senior personnel in 371 NHS trusts in England with regard to specialist and advanced nursing roles. The main findings covered employment issues, work activities and fields of practice. This study raises many questions about specialist and advanced nursing practice which will form the basis of an ongoing programme of research.

Employment↗
PubMedDate not supplied

The research role of the advanced nurse practitioner.

The research role of the advanced nurse practitioner (ANP) is poorly developed in the literature. Clarification of the role is essential if individual nurses are not to be burdened with unrealistic expectations. Organizations need to prepare themselves for research activities and must not expect the ANP to address all the issues involved alone.

Humans↗