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P Medicis

Publications and source records attributed to P Medicis.

6 recordsLinked to original sources
PubMed1988

[Prognostic and therapeutic significance of bone marrow biopsy in multiple myeloma. Analysis of 31 stage II A and III A patients].

The prognostic value of bone marrow biopsy was established in 31 patients suffering from stage IIA and IIIA myeloma (Durie and Salmon classification). Data obtained from quantitative marrow cytology permit to differentiate 3 sub-groups of cells: plasmocytes, plasmoblasts, plasmocytes/plasmoblasts of which the incidence on the prognosis and the response to treatment was studied. There is a correlation between the response to MP and the nature of various cells populations and, on the other hand, the type of infiltration. A sub-group of patients, resisting to MP, was identified: diffuse plasmoblastic myelomas of poor prognosis. Induction poly-chemotherapy seems far superior over the MP combination, which was always a controverted issue.

Aged↗
PubMedDate not supplied

[Joint manifestations and Yersinia pseudotuberculosis. Correlation between the clinical and biological aspects].

The authors attempt to evaluate the specificity of Yersinia pseudotuberculosis (YPT) serology on the basis of 94 new cases of aseptic joint lesions associated with serology considered to be positive. The cases selected from the file of the International Reference Centre for Yersinioses (Institut Pasteur, Paris, Prof. H.H. Mollaret), were divided into 4 groups: group A (n = 46) where the joint lesions had no proven aetiology and the positive YPT serology makes the diagnosis of Yersiniosis possible; group B (n = 24) where the joint lesions had a precise aetiology other than yersiniosis; group C (n = 11) with cases of erythema nodosa with arthralgia and group D (n = 11) with cases of erythema unusual cases. Comparison of the results of serology in the 4 groups reveals that the serodiagnosis is not discriminative and that serotypes II and/ or IV are involved in more than 80 per cent of cases. At the present time, the authors believe that YPT infection, especially types II and IV, can not be confirmed purely on the basis of serological data, as they are in discordance with the epidemiology of the disease; the interpretation of the results in hampered by a twofold difficulty: the determination of the threshold of positivity and the existence of crossed reactions. Finally, the serology is contradicted in certain cases by the demonstration of another pathogenesis.

Adult↗
PubMedDate not supplied

[Aseptic arthritis after total knee prosthesis].

In 3 patients who developed acute arthritis of the knee 3 months to 5 years after insertion of a total condylar prosthesis, it was possible to formally exclude an infectious cause. A number of cytological and histological arguments confirm that these were cases of foreign body arthritis (polyethylene debris and metal dust). These cases of arthritis responded to local steroid treatment combined with a Yttrium synoviorthesis, in the absence of any antibiotic treatment. The synoviorthesis was performed in order to eliminate the real foreign body granuloma which develops and which can contribute to the loosening of these prostheses.

Adult↗