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Biomedical subjects

P Meister

Publications and source records attributed to P Meister.

At least 19 recordsLinked to original sources
PubMed1991

Pulmonary myofibroblastic nodules with "amianthoid features".

Two consecutive publications appeared 1989 in the same number of a medical journal, which reported peculiar spindle-cell tumors with dense collagen or hyaline nodules, exclusively in inguinal lymph nodes of adults. The first series of 22 cases bore the title "Palisaded myofibroblastoma, a benign mesenchymal tumor of lymph node", the second with 6 identical cases "Intranodal hemorrhagic spindle-cell tumor with "amianthoid" fibers". The following case report deals with a similar tumorous lesion, with multiple small pulmonary nodules, without recognizable lymph node constituents.

Biopsy↗
PubMed1990

Cytoskeletal heterogeneity of an epithelioid sarcoma with expression of vimentin, cytokeratins, and neurofilaments.

We studied an unusual sarcoma with morphologic features diagnostic of epithelioid sarcoma by conventional light microscopy, transmission electron microscopy, and immunohistochemistry. The primary tumor, which was located in the deep soft tissues of the buttock of a 32-year-old woman, and its metastases to lymph nodes, liver, and lung were available for investigation. The histomorphological and ultrastructural appearance of the primary tumor and its metastatic deposits were typical of epithelioid sarcoma. Immunohistochemistry revealed a strong and uniform reactivity for vimentin in both the primary tumor and its metastases. In contrast, a marked cytoskeletal heterogeneity became evident for cytokeratins and neurofilaments, which were observed exclusively in lymph node metastasis. To our knowledge, the observation of neurofilaments in epithelioid sarcoma has not previously been reported.

Adult↗
PubMed1990

[Ultrasound diagnosis of benign teratoma of the thyroid gland].

We report about a six-year old girl who underwent a hemithyroidectomy because of a teratoma in the right thyroid gland. In ultrasonography, the teratoma shows a rather well limited tumor in the right thyroid gland. It shows no signs of infiltration or compression of adjacent structures. The inner structure of the teratoma is characterized by an inhomogeneous and mixtured picture of high density echos, low density echos and areas without echos. Although the localisation of the tumor was possible by ultrasonography, the specific diagnosis of a teratoma remains difficult.

Child↗
PubMed1989

[The morphology of chemically induced kidney tumors of the rat as a model for the typing of human kidney tumors].

1. 109 renal cell carcinomas were produced in 92 Wistar rats by a single dose of 80 mg/kg diethylnitrosamine 4, 16, 24 h after partial liver resection. These tumors showed a wide variety of morphological appearances, comparable with different types of human renal cell carcinomas, as proposed by THOENES et al. in a new cytomorphological classification. However, there were striking differences as to the incidence of the individual tumors types. Whereas clear cell tumor prevailed in human they were very rare in the animal experiment. 2. 54 renal cell carcinomas were produced in 105 rats by a single dose of 30 mg/kg dimethylnitrosamine after a low-protein diet of 5 days. Also in this experiment a variety of different tumor types resulted. Already in early "tubular lesions" a strikingly elevated thymidine labelling was found, in contrast to the surrounding regular tubular epithelial cells. Moreover, topographical relations of various tumor cell types to different segments of the nephron became evident. Besides a fair number of basophilic tumors with transition into proximal tubular epithelial cells, a large number of tumors showing abundant, typically vacuolated cytoplasm became evident. These tumor cells showed in general the highest labelling index with thymidine. They apparently are related to the distal nephron and possibly constitute neoplasms of the collecting ducts, compatible with otherwise rare ductus Bellini carcinomas. Concluding, the heterogeneity concerning tumor cell types and labelling indices has to be emphasized, whereby the latter also, appear to be dependent on the vascular blood supply.

Animals↗
PubMed1988

Malignant fibrous histiocytoma. History, histology, histogenesis.

At the XVI. International Congress of the International Academy of Pathology (Vienna, 1986), a session was dedicated to the classification of soft tissue tumors. At this occasion a critical review of malignant fibrous histiocytoma (MFH) was presented. A) The history of MFH revealed that this tumor had been known for many years under a variety of names. Moreover, MFH apparently had frequently been misinterpreted as other tumor types, as for instance rhabdomyosarcoma. Today, there is a discrepancy between the high incidence of MFH among soft tissue sarcomas and its underrepresentation in some widely used tumor classifications. B) The histological appearance may be fully developed and typical for MFH. However, it also may be merely compatible with MFH in less typical tumor areas. Regional differences in morphological appearance may be pronounced. Differential diagnosis can be helped by histochemical methods. C) Histochemical methods--among others--also help to shed light on the histogenesis. More recent findings point to MFH, as a tumor of fibroblasts rather than histiocytes with similarities to loose areolar connective tissue. Although MFH-like areas may occur focally within a variety of different tumors, there remains a large group of sarcomas which do not display any signs of further differentiation even after careful work-up. In these cases the application of the term MFH, as it is understood today, appears to be justified.

Cell Differentiation↗
PubMed1988

[Soft tissue sarcomas. Classifying and/or grading?].

Grading of soft tissue sarcomas cannot substitute for their accurate classification. The latter, according to the historical typing of soft tissue tumors, as proposed by WHO (1969), has to be considered as presumptive for morphological grading. The parameters given for grading are subject to individual bias and artefacts. They are also influenced by the "histogenetic types" of tumors. To achieve some correlations between morphological grading and prognosis, grading parameters (atypia and mitotic activity) have to be weighted differently, according to tumor type. Immunohistochemical methods are helpful in accurate typing of tumors where classification is difficult. The future search will be concerned with more objective methods for grading, including immunohistochemical determination of proliferative markers (similar to Ki67) or flow-through cytophotometry. All efforts are oriented to achieving an optimal correlation between grading parameters on the one hand, and prognostic predictions on the other.

Fibrosarcoma↗
PubMed1979

Osteosarcoma: histological evaluation and grading.

With 60 cases of osteosarcomas a histological evaluation from + to +++ carried out for mitoses, osteoid formation, presence of multinucleated giant cells, and tumor necrosis. A subclassification in osteoblastic, chondroblastic, and fibroblastic type of osteosarcoma (according to Dahlin) and a histological grading from + to +++ based on degree of cellular atypism was also done. In our material no relations between these three types of osteosarcoma and chance for survival became evident. There was, however, a significant correlation between grade of atypism and rate of mitoses. Grading of oestosarcomas from + to +++ showed that cases with grade III osteosarcoma remained only seldomly without metastases during the course of the disease. Grade I osteosarcomas and also grade II tumors showed a higher number of patients with 2-year survival. However, neither correlation between tumor grade and incidence of metastases, nor with chances for survival were statistically significant. Nevertheless, characterization of osteosarcomas, by a histological grading from + to +++ based on cellular atypism and mitotic count is advisable, in addition to the TNM stages. This histological grading appeared to be more practicable than subclassifications of osteosarcoma by type which had been tested by us in a previous study (Konrad et al., in press).

Humans↗
PubMed1979

Fibrous histiocytoma: an analysis of the storiform pattern.

A storiform pattern is an important structural feature of fibrous histiocytoma (FH). In this analysis reconstructions of histological patterns were carried out from drawings. Highly FH with only a suggestion of storiform pattern and small star-formations were seen, there were other lesions with more pronounced fiber formation which showed more distinct and larger storiform stars. These structures can frequently be followed for only 3 sections of 5 micron thickness. In contrast to leiomyomas or meningioma, no regular or consistent orientation of these structures with respect to vessels is evident. Storiform structures apparently develop at the periphery of adjacent proliferating cells groups. They show a typical and diagnostically significant histological pattern, which was found to some degree in all FH examined.

Histiocytoma, Benign Fibrous↗
PubMed1979

Fatal eosinophilic gastroenterocolitis in a two-year-old child.

We report a case of eosinophilic gastroenterocolitis in a 2-year-old child with extensive fibrosis, atrophy of the muscularis propria and involvement of stomach, small bowel and colon. Following an attack of acute gastroenteritis at the age of 15 months the symptoms of ileus persisted. A biopsy of small bowel at the age of 18 months showed numerous eosinophilic granulocytes in the mucosa. At the age of 28 months the child died with paralytic ileus. This is the first case known to us of an eosinophilic gastroenteritis in early childhood with a fatal outcome.

Colitis↗
PubMed1979

Analysis of proliferative compartments in human tumors. I. Renal adenocarcinoma.

Vascular perfusion of 16 renal adenocarcinomas with radioactive DNA precursors provides a possibility of characterize proliferative compartments of this tumor type. Immediately after resection of the tumor-bearing kidney, the organ is perfused via renal artery with dextran-diluted, heparinized oxygenated blood at physiological temperature, pH, flow, and pressure in a recirculation system. DNA synthetizing cells are labeled by addition of 3H- or 14C-thymidine or both isotopes at different intervals. Beta camera scans and whole-tumor autoradiograms disclose a striking proliferative heterogeneity of the tumor. Cell proliferation depends on intratumoral localization, cellular differentiation, histological structure and vascular supply. Subpopulations of high proliferative activity are found at the invasive borderline near normal kidney, focally in subcapsular areas and in intrarenal metastases, but also immediately adjacent to necrotic areas in the tumor center. Quantitative evaluation of autoradiograms yields, at the cellular level, a significantly higher labeling index in granular cells (3.21%) than in clear cells (0.65%), with a large variability dependent on the histological structure. The highest number of DNA synthetizing cells is seen in papillary and mixed solid-tubular zones and at peripheral parts of solid areas, whereas in central parts of solid tumor cords and in highly differentiated tubular areas lower labeling indices are observed. The labeling index decreases exponentially as a function of the distance from the supporting blood vessel. In solid cords, no labeled cells are seen at a distance of more than 200 micron from the capillary. The ts determined by 3H/14C-thymidine double labeling is between 9.9 and 16.8 hr for granular cells and about 9.2 hr for clear cells. Potential population doubling time calculated for various subpopulations yields values between 4 and 50 days. It is concluded that cell loss is high, for granular cells in particular. Besides cell loss, a large nonproliferating compartment contributes to a delay of the tumor volume doubling time. Proliferative heterogeneity of advanced human tumors, as exemplified by the renal adenocarcinoma, bears important implications for therapy and prognosis.

Adenocarcinoma↗
PubMed1979

Malignant tumor of humerus with features of "adamantinoma" and Ewing's sarcoma.

This female patient was born in 1935 and died in 1976 with a malignant bone tumor involving the proximal humerus following multiple local recurrences, axillary lymph node metastases, and pulmonary metastases. Histologically, over the course of time, there was an increase in features of an atypical Ewing's sarcoma, at the expense of findings of a typical, extra-cranial so-called adamantinoma. In contrast to another report, our case showed neither epithelial nor endothelial features on fine structural examination, but rather primitive mesenchymal cells, as is described for Ewing's sarcomas.

Adult↗
PubMed1979

Palmar fibromatosis-"Dupuytren's contracture". A comparison of light electron and immunofluorescence microscopic findings.

A comparison of light, immunofluorescence and electron microscopic findings in palmar fibromatosis (Dupuytren's disease) revealed that the three morphologic phase of Luck; I. proliferative, 2. involutional, and 3. residual, corresponded for the most part to I. fibroblastic, 2. myofibroblastic or 3. fibrocytic lesions, respectively. The spectrum between proliferative phase and residual phase appeared immunohistochemically as a decrease in collagen type III, and an increase of collagen type I. Myosin was found in substantial quantities only during the involutional phase, distinguished by myofibroblasts, presumably with contractile capabilities. Thus, the clinical presence of contractures with palmar fibromatosis might also be explained in the absence of distinct fiber formation.

Collagen↗
PubMed1979

[Non-Hodgkin's lymphoma in children: improved prognosis through aggressive multiple drug combination and irradiation (author's transl)].

From 1964-1975 43 children with non-Hodgkin's lymphoma (NHL) were treated. 60% of the patients had far advanced disease at diagnosis. Therapy before 1970 consisted of low dose irradiation to the primary and single agent chemotherapy; no C.N.S. irradiation to prevent meningeal recurrence was given. Median survival in this group was 5 months; all patients died. Since 1970 all children with NHL were entered into a modified leukaemia protocol regardless of stage or primary site. Therapy comprised an aggressive multiple drug combination, high dose local irradiation and prophylactic C.N.S. irradiation with intrathecal methotrexate. 41% of the patients treated since 1970 survive in continuous complete remission with a median observation time of 31+ (1-93+) months. All relapses occurred within 30 months after diagnosis. Stage of disease was the most important prognostic factor in our patients. Risk of a primary C.N.S. relapse in the total group was 30% for patients without prophylactic C.N.S. therapy compared to only 6% for patients with treatment.

Adolescent↗
PubMed1978

Nephroblastoma and neuroblastoma--histology and prognosis.

Statistically evaluating the influence of a histological grading, respectively of morphological differences on prognosis of nephroblastomas and neuroblastomas, better chances for survival become evident not only for earlier clinical stages, but also for nephroblastomas with high differentiation, or neuroblastomas with signs for differentiation. Only for neuroblastomas a relevant predeliction of tumors with signs of differentiation for the early clinical stage I is present. Combined subclassification according to clinical stages and histological grades results in 3 risk groups with different chances for survival. These 3 groups may play a role for specific therapeutic considerations.

Child, Preschool↗