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Biomedical subjects

P Michael

Publications and source records attributed to P Michael.

15 recordsLinked to original sources
PubMed2001

Psychiatric bed utilization: 1896 and 1996 compared.

BACKGROUND: The 1896 and 1996 populations of North West Wales are similar in number, ethnic and social mix and rurality, enabling a study of the comparative incidence and prevalence of service utilization over the course of a century. METHODS: We collected records on all psychiatric admissions from North-West Wales in 1894-1896 and 1996. These were assessed and diagnosed by the responsible sector area consultant. RESULTS: The data reveal substantially more patients admitted for all diagnoses in 1996. even when comparisons are restricted to detained patients. The incidence of hospitalization by detention for schizophrenia is slightly lower 1996 than in 1896 but the incidence of hospitalization is higher now than in 1996. The incidence of hospitalization by detention for non-affective disorder psychoses is the same in both 1896 and 1996 but there is a doubling of incidence of hospitalization. The incidence of hospitalization for bipolar disorders is similar in the two periods. Modern mental health services admit large numbers of personality disordered patients, where none were admitted 100 years ago. CONCLUSIONS: Factors general to changing health care and expectations and others specific to mental health would appear to have led to the increase in rates of admissions observed in the modern period.

Adult↗
PubMed1998

Pyomyositis.

A case of non-tropical pyomyositis (PM), in a 63-year-old female patient, affecting gluteus and intrapelvic muscles is presented. Delayed diagnosis and treatment led to long-standing morbidity. Magnetic resonance imaging (MRI) of the pelvis provided valuable information on the nature and extent of the disease and helped to plan surgical management. MRI of the pelvis should be undertaken at an early-stage. Prompt examination of material obtained by aspiration or debridement would then permit an accurate diagnosis and appropriate management.

Anti-Bacterial Agents↗
PubMed1996

Positive steps toward a multicultural association.

Diversity is a common denominator in all three initiatives of ADA's 1996-1999 Strategic Framework, "Creating The Future." With a diversified membership and practice base, which can be achieved by incorporating diversity within the Association's member initiative, ADA will more effectively accomplish its policy and public education activities. Members of ADA's Diversity Committee believe increased communication with the Association's members is one of the best strategies to identify and promote diversity accomplishments and opportunities. "Creating the Future" for dietetics professionals can be accomplished for all members if we all work together on this important task.

Black or African American↗
PubMed1989

Effects of dexamethasone on the incidence of acute mountain sickness at two intermediate altitudes.

To test the value of dexamethasone acetate for ameliorating acute mountain sickness (AMS), we conducted a double-blind, randomized study that compared the effects of 4 mg of dexamethasone acetate or a placebo (given every six hours for six doses beginning at the time of exposure) at 2700 and 2050 m. Study subjects, who were recruited from health professionals who attended continuing medical education programs at ski resorts in the Rocky Mountains, were classified as having AMS when they reported three or more of the five usual symptoms (headache, insomnia, dyspnea, anorexia, and/or fatigue) on a single day. All symptoms with an intensity of at least grade 2 (moderate) out of 5 were analyzed. At 2700 m, there was a 50% decrease in the mean AMS symptom score in the dexamethasone group (0.94 +/- 1.11 vs 1.84 +/- 1.44 [mean +/- SD]) and the incidence of AMS was 20% of that in the control group (3/38 vs 14/35). At 2050 m, there was no difference between dexamethasone and a placebo in the mean AMS symptom score (1.52 +/- 1.50 vs 1.24 +/- 1.33) and the incidence of AMS (5/25 vs 4/25). Dexamethasone ameliorates the usual symptoms of AMS at 2700 m but not at 2050 m.

Adult↗
PubMed1986

RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.

A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.

Cell Line↗
PubMed1986

Elevation of c-abl-mRNA in human leukemic B lymphoblasts.

Analysis of v-abl-homologous transcripts in peripheral blood leukocytes from 20 leukemia patients revealed a 5-kb species as the major abl-mRNA present. Elevated levels of this 5-kb transcript, together with detectable levels of 2- and 10-kb abl-homologous species, were observed in mRNA samples from two patients, one with Philadelphia chromosome (Ph')-positive chronic myeloid leukemia (CML) in lymphoid blast crisis, and the other with childhood Burkitt-type B-lymphoblastic leukemia. These abl-homologous transcripts differed from the aberrant 8-kb abl-mRNA reported by others in Ph'-positive CML patients in both size and extent of v-abl-homology. No alteration in the organization of v-abl-homologous sequences was detected in the genomic DNA of the Ph'-positive CML patient. Karyotypic analysis of the Burkitt-type B-lymphoblastic leukemia patient revealed the presence of an 8,14 translocation together with a number of other chromosomal aberrations. However, no abnormality of chromosome 9 could be detected. Hence, the observed increase in c-abl transcription is not consistently associated with either gross gene rearrangement or presence of the Ph'. The high levels of c-abl mRNA may be a function of the cell type involved (early lymphoid blast), suggesting that failure to down-regulate c-abl may be a factor in the onset of pre- or early B-lymphoid leukemias.

B-Lymphocytes↗
PubMed1984

Are the primordial germ cells (PGCs) in urodela formed by the inductive action of the vegetative yolk mass?

In the present study, when carefully demarcated areas of blastula animal cap were combined with the vegetative yolk mass, PGCs occurred only in those combinations which included the equatorial marginal zone of the animal cap. Furthermore, removal of the vegetative yolk mass as early as stage 6 1/2 did not affect the formation of PGCs. On the basis of these and other observations it is suggested that in urodeles, as in anurans, PGCs may develop from specific cells which nevertheless differentiate into PGCs only when suitable mesodermal elements are formed.

Ambystoma↗
PubMed1977

Estimation of ABO system antibodies by an automatic technique.

Detection of ABO system antibodies of IgG class in human sera is of importance both for diagnosis of feto-maternal incompatibility and for transfusiology. Inactivation of IgM and IgA class antibodies by 2-mercaptoethanol with subsequent estimation of IgG class antibodies, insensitive to 2-mercaptoethanol, serves as one of the approaches to the problem. In serological studies, IgG class antibody level is usually determined by the indirect antiglobulin test. Since the automatic technique is regarded as more accurate, we have attempted to adapt it to estimation of the ABO system antibody level.

ABO Blood-Group System↗