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Biomedical subjects

P Migasena

Publications and source records attributed to P Migasena.

At least 19 recordsLinked to original sources
PubMed1992

Lipid profile, anthropometry and dietary intake of 132 Thai vegetarians.

The anthropometric measurements, lipid pattern and dietary intake of 64 male and 68 female Thai vegetarians (mostly lacto-vegetarians) were investigated. 32 males and 36 females on an ordinary Thai diet served as controls. Nutritional anthropometric variables and serum lipid concentrations, which the exception of triglycerides, were found to be lower in the vegetarian group than in the control group. The vegetarians consumed more energy than the controls. No difference in the protein intake was observed in both groups. Fat intake was, however, lower and carbohydrate intake higher in the vegetarian group. Also in the vegetarian group, HDL-cholesterol fraction correlated negatively with anthropometric measurements. Other fractions show only a weak correlation, if at all, in this group. A good correlation to all serum lipid variables determined to anthropometric measurement was observed in the control group.

Adult↗
PubMed1992

Nutrition and the environmental situation in Bangkok.

Bangkok, the capital of Thailand, is a large city of about six million people. According to the rapid growth of economy, Bangkok faces to the problems of urbanization and industrialization. Non-communicable disease such as cardiovascular diseases, cancers are the leading causes of death. There is a trend of increasing air pollution in the congested areas and industrialized zones, with the increase over the ambient air quality standard involving suspended particulate matter. Other public health problems include the sanitation of restaurants, the quality of drinking water and coloring agents in food, drug addiction especially in young males. Poor hygiene in drug injection is one of the major causes of HIV transmission. AIDS, originally our imported disease, needs urgent prevention by health education and counseling. Improvements in government and non-government health care resources are still needed. A good cooperative city health plan serves a practical purpose, especially for the solution of the air and water pollution in Bangkok. However, pilot operational research on nutrition, health and environment in relation to city health planning needs to be discussed further for more effective implementation.

Child, Preschool↗
PubMed1991

Anthropometry, lipid- and vitamin status of 215 health-conscious Thai elderly.

A survey was carried out on 59 males and 146 females aged 60 years and above from a special clinic for the elderly in Bangkok. All of these subjects had no major complaints of ill health and, judging by their appearance, they seemed to be apparently healthy. 6.8% of the males and 11% of the females were found to be over-nourished. Less than 15% of all the individuals under investigation were suffering from hypertension, hyperglycaemia and hyperuricaemia. 35% of the males but only 13% of the females were anemic. The lipid status of the females was generally worse with statistically higher median values for total cholesterol, LDL-cholesterol and triglycerides than the males. There was no significant difference in the variation of HDL-cholesterol between the sexes. High vitamin C, B2 and B6 deficiency rates were observed in both the males and the females.

Aged↗
PubMed1991

Vitamin B1, B2 and B6 status of vegetarians.

The vitamin B1, B2 and B6 status was determined in 132 healthy vegetarians, age range 25-57 years who have been practising vegetarianism for 1-22 years. Sixty-eight healthy non-vegetarians were chosen as controls. The conventional methods to measure the activation coefficient alpha ETK, alpha EGR and alpha EAST were applied to assess the vitamin status of B1, B2 and B6 respectively. The value of 1.25 alpha ETK, 1.5 alpha EGR and 2.0 alpha EAST and above indicate a deficiency in the vitamin status. The results showed significantly poorer vitamin B1 and B6 status in vegetarians than in non-vegetarians, whereas, no significant difference in vitamin B2 status was found. None of the non-vegetarians were deficient in vitamin B1 but 3 of them (4.4%) were deficient in vitamin B6. On the other hand, 10 of vegetarians (7.6%) were deficient in vitamin B1; 38 (28.8%) in vitamin B6. A high prevalence of riboflavin deficiency was found in 32 (24.2%) of the vegetarians; as well as in 15 (22.2%) of the non-vegetarians. Only riboflavin status was significantly related with the duration of vegetarianism practiced. Vegetarians should be considered as the vulnerable group for vitamin B2 and vitamin B6 deficiencies. B-vitamins status should be checked and efforts should be made to improve through dietary counselling and nutritional education should be included and stress in the health education program in order to improve nutritional deficiencies.

Adult↗
PubMed1991

B vitamins status: effect of prolonged heroin addiction and methadone treatment.

Vitamin B1, B2 and B6 status were determined in 90 male heroin addicts admitted to Pramongkutklao Army Hospital. Their age (Mean +/- S.D.) was 25.5 +/- 7.8 years. Their activation coefficients of the enzyme transketolase, glutathione oxidoreductase and aspartate aminotransferase (ETK AC, EGR AC and EAST AC respectively) were significantly increased for addicts who were on drugs for a long time which indicated a biochemical deficiency. In addition, 26 follow-up cases treated with methadone for a period of one and two weeks were compared before and after treatment and it was found that ETK AC, EGR AC, and EAST AC were significantly decreased. This means that improvement in the vitamin B1, B2 and B6 status was obtained during admission.

Heroin Dependence↗
PubMed1990

Serum unconjugated primary and secondary bile acids in patients with cholangiocarcinoma and hepatocellular carcinoma.

Serum unconjugated primary bile acids (cholic acid, chenodeoxycholic acid), secondary bile acids (lithocholic acid, deoxycholic acid), conjugated primary bile acids (glycocholic acid, glycohenodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid) and total bile acids were measured in 25 and 75 male patients with cholangiocarcinoma and hepatocellular carcinoma respectively. Twenty-one healthy male volunteers served as controls. Other biochemical parameters, i.e. bilirubin, transaminases, albumin, globulin and cholesterol were also studied. Conjugated bile acids and total bile acids were elevated in both patient groups when compared with those of controls. The presence of unconjugated primary bile acids and secondary bile acids was noted in the patient groups, whereas, they were not detectable in controls. The appearance of these serum bile acids may be useful as a marker for early diagnosis of cholangiocarcinoma and hepatocellular carcinoma in people at-risk such as those who have chronic infection with Opisthorchis viverrini. Differentiation between the two types of tumor may be possible by using other parameters such as alpha-fetoprotein or other tumor markers newly discovered. An increase of the trihydroxy bile acids: dihydroxy bile acids and glycine conjugated bile acids: taurine conjugated bile acids ratios was shown in the patient groups. The latter may be due to the proportion of the increase of taurine conjugates being greater than the increase of glycine conjugates. The other biochemical parameters were significantly elevated in the patient groups except for albumin which was significantly decreased. The sensitivity of the tests for cholic acid, chenodeoxycholic acid, alkaline phosphatase and gamma glutamyl transferase was high.

Adenoma, Bile Duct↗
PubMed1990

Vitamin B1, B2 and B6 in relation to anthropometry, hemoglobin and albumin of newborns and their mothers from northeast Thailand.

The weight and height measurements of fifty-three mothers and their newborns residing in the northeast of Thailand were recorded. Hemoglobin, albumin and cord blood samples were taken immediately after delivery. The vitamin B1, B2 and B6 status of the women and their newborns was assessed through functional tests. Vitamin B1 and B2 status of the newborns was found to be generally better than those of their mothers. This is not so, however, for vitamin B6. The rate of deficiency in the mothers was highest for vitamin B2 (54.7%). The mothers' height, hemoglobin and albumin concentrations and their vitamin B2 status correlated with those of their children at birth. 50% of low birth weight deliveries (2500 g and below) were included in this study. The risk of a low birth weight delivery cannot, however, be explained by any of the biochemical variables. Although the rate of low birth weight is used commonly to determine mother and child health care, this paper shows that for Hb, albumin, Vitamins B1, B2 and B6, it is not an effective indicator used to determine nutritional deficiencies in mothers.

Anthropometry↗
PubMed1990

Aspects of community-based nutritional intervention.

A number of aspects are discussed in relation to community-based nutrition intervention projects. This includes the application of different intervention measures, the used of anthropometric indicators, and the methods of immediate and final data evaluation.

Child↗
PubMed1988

Lipid composition of serum lipoprotein in opisthorchiasis.

Lipid composition (i.e. total cholesterol, free cholesterol, cholesteryl ester, triglycerides and phospholipids) in the individual serum lipoprotein fractions (i.e. high-density lipoprotein, low-density lipoprotein and very low-density lipoprotein) were studied in 24 healthy controls and 18 opisthorchiasis patients admitted to the Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine. The two groups were similar in age range, sex ration and anthropometric data. Other background data such as blood pressure and alcohol consumption, were also similar in the two groups. All the patients had the habit of eating raw or half-cooked fish. Abnormalities of high-density lipoprotein content in the opisthorchiasis group showed as low cholesterol and cholesteryl ester concentrations but with high triglyceride concentrations. These may result from disturbance of the synthesis of nascent disk high-density lipoprotein or the removal of lipid content in lipoproteins.

Adolescent↗
PubMed1988

Serum protease inhibitors in opisthorchiasis, hepatoma, cholangiocarcinoma, and other liver diseases.

Serum alpha 1-antitrypsin, alpha 1-antichymotrypsin and alpha 2-macroglobulin increased significantly in patients suffering from liver diseases: hepatoma, amoebic liver abscess, hepatitis, hepatic cirrhosis, cholangiocarcinoma, carcinoma of the head of pancreas including liver fluke infection (opisthorchiasis). Marked increase of alpha 1-antitrypsin and alpha 1-antichymotrypsin were found in cholangiocarcinoma, carcinoma of the head of pancreas, amoebic liver abscess, hepatic cirrhosis and hepatoma. alpha 2-macroglobulin increased markedly in hepatic cirrhosis. The concentrations of protease inhibitors found in opisthorchiasis were only moderately elevated.

Adenoma, Bile Duct↗
PubMed1985

Pyridoxine status in preschool children in northeast Thailand: a community survey.

Pyridoxine status was investigated in four hundred and twenty-four village preschool children aged 1-60 months in Khon Kaen, and Nakorn Rachseema, Northeast Thailand using the erythrocyte aspartate aminotransferase (EAST) test and pyridoxal-5-phosphate activation coefficient (AC). Twenty-two percent of the children had pyridoxine deficiency, of which 15 percent had an AC greater than or equal to 3.37 and 7 percent had border-line deficiency (AC between 3.08-3.36). The prevalence of pyridoxine deficiency increased with age from 11 percent in the first year to 31 percent in the age range of 49-60 months.

Aspartate Aminotransferases↗
PubMed1979

The serum protein pattern in primary hepatoma and amoebic liver abscess.

A study of the serum proteins pattern of 30 patients with primary liver cell carcinoma and 11 with amoebic liver abscess was carried out. When compared with controls significant differences were found for both conditions in the values of pre-albumin, transferrin, albumin, haptoglobin, alpha 2-macroglobulin, and alpha 2HS-glycoprotein. In the differential diagnosis of amoebic liver abscess and primary hepatic carcinoma, the estimation of albumin, alpha 1-acid glycoprotein, haptoglobin ceruloplasmin, alpha 2H2-glycoprotein and transferrin was found helpful.

Adult↗