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Biomedical subjects

P Mignot

Publications and source records attributed to P Mignot.

17 recordsLinked to original sources
PubMed1991

Activity of intrapleural recombinant gamma-interferon in malignant mesothelioma.

Twenty-two consecutive patients with malignant diffuse pleural mesothelioma were treated with recombinant gamma-interferon by the intrapleural route. Diagnosis was made by thoracoscopic examination and all cases were confirmed by the French Mesothelioma Panel of Pathologist. Patients were staged based on thoracoscopic examination and computed tomography (CT) scan: 12 patients were classified as Stage I and 10 were Stage II. A solution of gamma-interferon (40 X 106 U) was infused twice a week over 2 months. Every patient experienced fever. One patient had a Grade 2 leukopenia and one patient suffered from pleural empyema. Response evaluation was based on the following: (1) CT scan performed 2 weeks after treatment ended, and (2) repeat thoracoscopic examination with histopathologic verification in nine patients who had demonstrated a stabilization or a regression of the disease on CT scan. From the original group, 19 patients could be evaluated. Four complete thoracoscopic histopathologic responses and one partial response were observed in Stage I patients (56%). One partial response was observed in Stage II patients.

Alkaline Phosphatase↗
PubMed1986

[Critical study of methods for the diagnosis of allergic asthma].

A search for an allergic cause in asthma is fundamental to the diagnosis. Typically it is based on: A clinical history. Specific cutaneous and inhaled provocation tests which can produce a possible reaction (early and delayed) which are of great pathophysiological and therapeutic interest. In vitro tests (which enable the different phases of the allergic reaction to be distinguished) to know the serum IgE antibody levels (total IgE, specific IgE and their fixation to cell receptors) cell tests on the degranulation of basophils and the dosage of chemical mediators: histamine, leukotrienes, prostaglandins, P.A.F. in the serum or in the bronchial alveolar lavage liquid, from the study of cells or tissue samples. In this regard the authors stress two recent techniques enabling direct access to bronchial tissue and the pulmonary parenchyma, which are bronchoalveolar lavage and bronchial biopsy, both are possible today by using a fibroscope. The broncho-alveolar lavage still remains in the research area, and is not always well tolerated in asthmatics. It already allows a better definition of the major allergic cytological and biochemical components in asthma (IgE, IgA, albumin, phospholipids, mast cells and eosinophils). Bronchial biopsies with ultra-structural studies, and above all immunopathology (by immunofluorescent techniques and peroxidase stains) enable groups of asthmatics to be uncovered who were considered as non-allergic by the unsuspected intervention of hypersensitivity mechanisms to IgE (the presence of cells carrying IgE); these biopsies enable the importance of inflammatory factors to be confirmed and equally to establish the prognosis in certain asthmatics by the degree of irreversibility of the lesions (fibronectin).(ABSTRACT TRUNCATED AT 250 WORDS)

Asthma↗
PubMed1985

[Intravascular bronchioloalveolar tumor or I.V.B.A.T. Apropos of a case and review of the literature].

Intravascular bronchioloalveolar tumor is a rare tumour of the lung. Having observed a case detected during systematic examination in a 44-year old woman, the authors compare the radiological, clinical, histological and evolutive signs of the disease with those reported in the 40 cases published since the first description by Dail and Liebow, in 1975.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1985

[Tissue immunopathology methods for the diagnosis of bronchopulmonary diseases].

The authors draw attention to the diagnostic value of tissue immunopathology methods in numerous bronchopulmonary diseases. Having emphasized the strict technical requirements and difficulties of these methods--all obstacles that are necessary for an accurate evaluation of the lesion--they use concrete examples to demonstrate the usefulness of extra-thoracic, skin or muscle biopsies to diagnose some systemic diseases, such as lupus erythematosus or Churg and Strauss syndrome. They also refer to bronchial biopsies which provide information on the aetiology and pathogeny of adult asthma, and to the prognostic and therapeutic value of collagen studies in idiopathic pulmonary fibrosis.

Aged↗
PubMed1985

[Protected distal aspiration in the identification of pathogenic microorganisms in pneumologic intensive care].

To identify the micro-organisms responsible for bronchopulmonary infections in intensive care patients is an absolute prerequisite to successful treatment. Numerous techniques of specimen collection have been used to facilitate this bacteriological diagnosis. In this study, which involved 27 intensive care patients selected according to various criteria of infection, endotracheal aspiration (a commonly used but not very specific technique) was compared with protected distal brushing under fibroscopy and with protected distal aspiration. The latter method, still seldom used, proved as specific as protected distal brushing (hitherto regarded as the reference method), but it also presents the enormous advantages of being rapid, non-traumatic, devoid of side-effects and easily performed in hospital routine by paramedical staff.

Adult↗
PubMed1978

[Surgery of retrospinal disinsertion of the posterior cruciate ligament of the knee (author's transl)].

Thus in all cases of an isolated tear of the posterior cruciate ligament, with an interglenoid fragment, whe fixation by a screw or clip was carried out, we obtained good results by simple surgical treatment. In spite of the small size of this series, the results were in perfect harmony with those of other authors, which justifies surgery. In three other cases of a tear of the posterior cruciate ligament, orthopedic treatment was adopted for various reasons; comparison of the results was definitely in favour of surgery owing to the duration of plaster immobilisation and physiotherapy in the first group and the functional sequelae with chronic invaliding laxity in the cases treated conservatively.

Follow-Up Studies↗
PubMed1975

[Treatment of fractures of the humerus by intramedullary fixation].

The Hackethal's technique of intramedullaring wiring for humeral fracture represents the immobilisation procedure particularly convenient for this bone. This procedure can be realised without special instrumentation with Kirschner's wires and image intensifior. To allow the approach of the fracture, the patient's position is choosed upon the topography of the lesion. The intramedullaring wiring is always done from down to up. Indications for this procedure are: humeral shaft fracture, humeral neck fracture, and fractures of the shaft and of the neck. During the reduction of the fracture, the immoderate use of a image intensifior seams to be the major risk. Hackethal's technique for medullary wiring was used in 21 patients, only one pseudarthrosis was noted. The fonctionnal recovery of the arm is usually realised in three months.

Adolescent↗
PubMedDate not supplied

[Results of primary reconstructive arthrodesis of the calcaneus (study of a homogenous series of 55 fractures of the medical surface of the calceneus)].

55 cases of calcanear fractures (thalamus) have been treated with the Stulz procedure (early subtalar arthrodesis and calcanear reconstruction), associated with a repair of the great apophyse. All the cases are comparable and the results are considered as good or excellent in 93,8 p. 100 of them. The results are interpreted accordingly to subjective and objective tests. The result is depending of the type of the lesion, the patient's profession and the nature of the trauma. The result obtained at the time of fracture uniting will stay stable, will never deteriorate and sometimes improve. The early arthrodesis and reconstruction remains a good procedure for the comminutive fractures of the thalamus, which are considered as the most difficult to correct perfectly. For this reason, the simple reconstruction is often responsible of secondary subtalar arthrosis.

Adolescent↗
PubMedDate not supplied

[Surgical treatment of calcanear fractures (103 cases). Reconstruction-arthrodesis, or reconstruction (author's transl)].

In a twelve-year period, 103 calcanear fractures (thalamus) were operated on, either by the Stulz procedure (calcanear Reconstruction-subtalar Arthrodesis [83 cases]), or by Reconstruction (20 cases). During the first seven years, the Stulz procedure had been performed systematically. During the following five years, indications were shaded between 28 reconstruction-arthrodesis and 20 reconstructions. A complete preoperative radiological study, including especially horizontal calcanear tomography enables to precise what type of injuries affects the four different parts of the calcaneus, and to choose between either procedure.

Adolescent↗