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Biomedical subjects

P Mileder

Publications and source records attributed to P Mileder.

8 recordsLinked to original sources
PubMed1999

Effect of specific immunotherapy with house dust mite extract on the bronchial responsiveness of paediatric asthma patients.

BACKGROUND AND OBJECTIVE: Allergic asthma is common in children, and house dust mite (HDM) is an important source of perennial allergens. Bronchial hyperresponsiveness is a functional hallmark of asthma. Specific immunotherapy (SIT) with HDM extracts were shown to decrease symptoms, but its effect on bronchial responsiveness, as measured by non-pharmacological challenges, has not been evaluated. METHODS: Twenty-six paediatric asthma patients allergic to HDM participated in this study. Fourteen patients received SIT with a HDM extract (Alavac, Bencard) for 2 years, and 12 served as controls. Bronchial responsiveness was assessed non-pharmacologically by cold dry air challenge (CACh) before and 3, 6, 12 and 24 months after SIT, and 12 months after termination of SIT. RESULTS: After 24 months, the SIT group showed a statistically significant reduction of the mean CACh-induced changes of both forced expiratory volume in one second (-21.8+/-2.7% vs. -13.7+/-2.4%; P = 0.03) and maximal expiratory flow at 25% remaining vital capacity (-48.9+/-4.9% vs. -27.9+/-6.2%; P = 0.01). In contrast, no significant changes of bronchial responsiveness were observed in the control group. In the SIT group more patients lost their bronchial hyperresponsiveness than in the control group (6/14 vs. 1/12; P<0.05). One year after terminating SIT, the treatment group showed a tendency towards returning bronchial hyperresponsiveness. CONCLUSION: These results demonstrate that during 2 years of SIT there was a reduction of bronchial hyperresponsiveness in HDM-allergic paediatric asthma patients.

Adolescent↗
PubMed1991

[Inspiratory stridor as the only symptom of esophageal foreign body].

An eleven month old infant girl presented with a two-month history of inspiratory stridor. Analysis of her symptoms indicated airway obstruction located in the middle of the trachea; a barium esophagogram revealed an esophageal foreign body with tracheal compression. By endoscopy, a chestnut shell was extracted from the esophagus. In infancy, esophageal foreign bodies may cause mainly respiratory symptoms.

Airway Obstruction↗
PubMed1990

[Significance of food allergens for the development of hyperreactive airway diseases].

Food allergies may lead to local and systemic allergic reactions. Participation of respiration tract is rare and is only noticed in combination with additional systemic allergic reactions. Food allergies seem not to have influence on the origin of bronchial hyperreactivity or Asthma. Furthermore the question of genetic influence on the origin of children's allergies and possible preventive measures are discussed.

Allergens↗
PubMed1990

[Ultrasound image of an unusual intrahepatic site of a bile duct cyst].

An intrahepatic cyst was found ventral and cranial to the gallbladder without choliangectasy in an infant of 8 months of age. Final diagnosis of a bile duct cyst was arrived at intraoperatively. The article discusses the possible aetiology, non-invasive diagnosis and sonographic differential diagnosis. Sonography is discussed as the method of choice in assessing intrahepatic and extrahepatic cysts and the bile ducts.

Bile Duct Diseases↗
PubMed1988

[Changes in renal echogenicity in pediatric obstructive uropathies].

Renal cortical echogenicity of 40 children with obstructive uropathies was analysed in relation to the grade of obstruction and thinning of the renal cortex. In 35 percent of the children an increase in echogenicity was noted. The increase in cortical echogenicity paralleled the grade of dilatation of the intrarenal collecting system and the grade of thinning of the renal cortex. Evaluation of the cortical echogenicity should be integrated into the primary diagnostic setup as well as into the follow-up of children suffering from obstructive uropathies.

Adolescent↗
PubMedDate not supplied

[Ultrasonography in urinary tract infection in infancy].

In a prospective study 77 infants (35 boys) with a mean age of 5.23 months were studied to determine the value of sonography for detection of renal parenchymal involvement in urinary tract infection (UTI). Sonography was performed during UTI and about one month later. UTI was classified as upper and lower UTI according to the clinical and laboratory findings; radiological investigations (voiding cystoureterography = MCU) were performed in all infants. 40 infants were classified to have upper UTI. There was a high sensitivity (80%) and specificity (97%) for detection of renal involvement by sonography. Incidence for vesicoureteral reflux (VUR) was significantly higher in infants with repeated pathological findings on sonography. In contrast, no VUR was detected on MCU in all 12 infants with normal findings in both sonographic examinations. Yet, sonography without catheterization could not detect VUR in all infants with radiologically confirmed reflux. Our results show, that sonography is of definite value in infants with UTI, but cannot replace radiological work up.

Female↗