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Biomedical subjects

P Mononen

Publications and source records attributed to P Mononen.

6 recordsLinked to original sources
PubMed1982

The value of a single intravenous dose of metronidazole as prophylaxis against wound infection after appendicectomy.

131 patients from 158 appendicectomies were randomly divided before the operation into two groups: a single intravenous dose of metronidazole, and a physiological saline placebo group. The overall infection rate was 8.4%. In the non-perforated cases the infection rates were 3.4% in the metronidazole and 7.9% in the placebo group. In cases with perforated appendix the infection rate was 40%. There was no statistically significant difference in the infection rates between the groups. Our results give no clear indication of the benefit of metronidazole prophylaxis and we propose, therefore, to concentrate on the technical aspects of appendicectomy in infection prophylaxis.

Adolescent↗
PubMed1977

Effects of open-heart surgery on carbohydrate and lipid metabolism.

The concentrations of blood glucose, serum insulin, free fatty acids, and triglycerides were examined preoperatively, during anesthesia, during extracorporeal circulation, and during the following 3 postoperative days in 29 patients. The patients were divided into three groups according to the duration of extracorporeal circulation and the use of hypothermia: short perfusion group (SPG, bypass time shorter than 60 minutes, 15 patients), long perfusion group in normothermia (LPGN, bypass time longer than 60 minutes, 8 patients), and long perfusion group in hypothermia (LPGH, temperature during bypass below 33 degrees C., 6 patients). In all three groups, the concentrations of free fatty acids and blood glucose rose significantly because of anesthesia (p less than 0.001). After cardiopulmonary bypass, the concentrations of free fatty acids diminished significantly. The blood glucose remained at high level until the second postoperative day and was significantly higher in the LPG than in the SPG (p less than 0.05). The serum insulin level remained low during anesthesia and extracorporeal circulation in the SPG and LPGH but rose during the postoperative period; the maximal values were recorded on the first postoperative day. There were no significant differences between the groups with regard to serum insulin during the study. These changes and their metabolic background are discussed.

Blood Glucose↗
PubMed1975

Axillary plexus block with etidocaine.

Axillary plexus block has been used to compare 0.5% and 1.0% etidocaine (with adrenaline 5 mug/ml) in 32 patients in an open label study. The injected volume was 30 ml. The time to total analgesia and motor block was around 10-12 minutes. Complete block was achieved in more than 97% of cases. The duration of total analgesia and motor block was 6-7 hours. The time from injection to return of total sensation and motility was 8.5-10 hours. Adequate analgesia was achieved in all patients but two (one in each group). No noteworthy differences were found between the two solutions.

Acetanilides↗
PubMed1975

Dipyridamole and thrombocyte count in open-heart surgery.

The effect of dipyridamole (Persantine) on the thrombocyte count in connection with open-heart surgery and perfusion was studied in 12 patients. A control series of 38 patients undergoing open-heart surgery was available. The dose of dipyridamole, depending on the duration of the perfusion, was 40 to 80 mg. intravenously. We found that dipyridamole definitely had the effect of maintaining the thrombocyte count. At the end of perfusion, the mean thrombocyte count in the dipyridamole group was 129 +/- 20.6 x 10(9)/L. and in the control group 82 +/- 7.4 x 10(9)/L. The result was statistically almost significant (p less than 0.05). At the end of anesthesia the respective mean values were 164.9 +/- 29.7 and 110.8 +/- 8.1 x 10(9)/L. The difference was almost significant (p less than 0.05). The use of dipyridamole did not increase the postoperative hemorrhagic tendency. Our results support the earlier experimental findings that dipyridamole favors the maintenance of thrombocyte counts.

Adult↗