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Biomedical subjects

P Moores

Publications and source records attributed to P Moores.

At least 19 recordsLinked to original sources
PubMed1996

Outcomes research: contemporary issues and historical significance for nurse practitioners.

Outcomes research is not new to the discipline of nursing. However, the driving forces of today's health care environment are resulting in increased emphasis on the study of outcomes. This article presents an overview of the scope of outcomes research, including a historical perspective and contemporary issues. Outcomes research provides an opportunity to demonstrate the effectiveness of nurse practitioner practice.

Humans↗
PubMed1994

Rh18 and hrS blood groups and antibodies.

Anti-hrS, also known as the Shabalala antibody, is unlikely to be found in unabsorbed human serum. The term 'anti-hrS, was devised by Shapiro in 1960 to describe the antibodies remaining in the absorbed serum after anti-Rh18 had been absorbed with R2R2 red cells. R2R2-absorbed anti-Rh18 (anti-hrS), although an interesting research tool, is therefore clinically irrelevant. Unabsorbed anti-Rh18, on the other hand, is a clinically significant antibody. It is compatible not only with Rh-'deleted' and Rhnull red cells, as described by Shapiro, but is also compatible with the red cells of numbers of Southern African Blacks and Coloureds (mixed race) who have Ro, Rou or R2r phenotypes. Anti-Rh18 causes haemolytic disease of the newborn and, when uncontaminated with other antibodies, is a further reagent for resolving Rh grouping problems.

Black People↗
PubMed1993

STEM, a new low-frequency Rh antigen associated with the e-variant phenotypes hrS-(Rh: -18, -19) and hrB-(Rh: -31, -34).

The new low-frequency antigen STEM was identified when a Cape coloured woman with an unknown antibody in her plasma (which agglutinated the red cells of her husband and a minority of other individuals) gave birth to a baby suffering mildly from haemolytic disease of the new-born. Most, but not all, examples of anti-STEM distinguish different strengths of STEM antigen on the red cells of different people; the different strengths are inherited. Family studies established that STEM was inherited as a Mendelian dominant character. STEM subdivides hrS-(Rh: -18, -19) and hrB- (Rh: -31, -34) red cells into two types: STEM+ and STEM-. The manually calculated lod score for STEM being associated with the Rh system is 3.91 and LIPED calculated lod score 4.35. The International Society of Blood Transfusion has allocated STEM the Rh number 49.

Female↗
PubMed1991

Rh33 in two of three German siblings with D+ C+ c+ E- e+ red cells.

The proposita in a German family of three siblings has D+ C+ c+ E- e+ f+ Rh: -17,19,33,34 red cells with weak C, e, f, Rh19, and Rh34 and stronger-than-usual Rh33 expression. One sibling has D+ C+ c+ E- e+ f+ Rh:17,19,33,34 red cells with weak f and ordinary-strength Rh33, and the other sibling has D+ C+ c+ E- e+ f+ Rh:17,19,-33,34 red cells. In the absence of any further family members, the proposita's unusual phenotype suggests that she has an RoHar haplotype and a "new" Rh haplotype, provisionally named R1Lisa, that encodes Rh33, normal-strength D, weak C, weak or nondemonstrable e, Rh19, and Rh34, but not Rh17. Her Rh:33 sibling may have R1 and RoHar and her Rh:-33 sibling R1 and r haplotypes.

Adult↗
PubMed1991

Serology and genetics of the red blood cell factor Rh34.

Rh34 antibodies were found to have a unique, previously only partly characterised, specificity within the Rh system. No evidence was seen that they were mixtures of hrB and Hr-like antibodies, or that hrB antibodies existed independently in the natural state. The term anti-hrB applied to Rh34 antibodies after they had been partially absorbed with R2R2 red cells. Four haplotypes not expressing Rh34 antigen were identified in the present study. The prefix * has been used to indicate them in this text. They were *r's (*dCces), *Ro (*Dce), *Rou (*D(uce)) and *R(od) (category III *Dce). Red cells with partially deleted or Rh(null) phenotypes were therefore not the sole red cells compatible with anti-Rh34. R2R2 red cells, which are known to carry weak Rh34 antigen, were incompatible. Twenty-two family and mother-child studies established that the Rh:-34 haplotypes were inherited as normal Mendelian dominant characters. Anti-Rh34 was capable of recognising RH 34 dosage and of excluding some men who had been wrongly accused in disputed paternity tests.

Adult↗
PubMed1991

D-- and Dc- gene complexes in the coloureds and blacks of Natal and the eastern Cape and blood group phenotype and gene frequency studies in the Natal coloured population.

Following the detection of apparent exclusions in the Rh system in two Coloured (mixed race) families during paternity testing, a rare D-- gene complex was identified in one family and two examples of an unusual gene complex producing weak e and very weak or non-demonstrable f antigen in the other. The latter, which almost certainly belong to the heterogeneous collection known as Dc-, were found when the Rh phenotypes expected to give f+, instead gave f- or f+W (weak positive) results and those expected to give f-, gave f+W results. Blood group phenotype and gene frequency studies showed that the Natal Coloured population contains a mixture of approximately 40% Black, 30% White and 30% Indian (Asian) genes. The phenotypes A1 high H, B high H, B low H, K+ and Kp(a+) associated with Caucasoids and the phenotypes Abantu, Dantu+, hrS- (Rh: -18,-19), hrB- (Rh: -31,-34) and Fy(a-b-) associated with Negroids were all represented. The DCe/Dc- frequency was 6.9% and the DcE/Dc- frequency 2.6%.

Black People↗
PubMed1990

Wd(a+) red blood cells in two sisters of a Hei//om Khoisan family in Namibia.

Two sisters in a Hei//om family of the southern African Khoisan race in Namibia were found to have Wd(a+) red blood cells. Wda is a low-frequency antigen identified so far only in a European family in Canada and a family in Holland. The Wda gene may have had an independent origin in the Khoisan. Alternatively, the Hei//om population may have acquired it through miscegenation.

Blood Group Antigens↗
PubMed1987

Congenital dyserythropoietic anaemia (type II) presenting with haemosiderosis.

A 39-year-old female with type II congenital dyserythropoiesis presented with iron overload. The clinical and haematologic features were an anaemia of variable severity, splenomegaly, numerous bizarre and binucleate normoblasts in the bone marrow, with prominent submembranous cisternae in the late forms, a positive Ham's acid lysis test and aberrant expression of the I and i red cell antigens. The iron overload resulted from gross ineffective erythropoiesis, with accelerated plasma iron turnover and increased absorption aggravated by inappropriate replacement therapy for past episodes of anaemia.

Adult↗
PubMed1983

Rhnull red cells and pregnancy.

The haemoglobin, haematocrit and osmotic fragility red cell values in a South African white woman with Rhnull cells and the corresponding haematological syndrome were shown to vary only minimally during her third pregnancy. This occurred in spite of the precautionary donation by her of two units of her blood at 20 and 27 weeks of pregnancy for storage in liquid nitrogen. Although there was fear to the contrary, the woman's infant was found at birth to be suffering only mildly from haemolytic disease of the newborn due to the anti-Rh29 antibodies present in her plasma.

Adult↗
PubMed1975

S--s--U-- phenotype in South African Negroes.

A Negro woman of the Xhosa tribe of Port Elizabeth in the Eastern Cape was found to be S--s--U--with anti-U in her serum. She had two S--s--U-- children, and her husband, father and other children all had single doses of S or s antigen. Three furhter S--s--U-- Negroes were found in a random sample of 1,000 Negro antenatal patients at Port Elizabeth.

Adult↗