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P Morrissey

Publications and source records attributed to P Morrissey.

4 recordsLinked to original sources
PubMed1990

Cephalosporins to carbapenems: 1-oxygenated carbapenems and carbapenams.

The photo "Wolff" rearrangement of readily available 2-diazoceph-3-em oxides (1) directly affords carbapen-2-ems, allowing a facile entry into a ring system previously accessible only by total synthesis, lengthly semisynthesis or fermentation. The chirality of the cephalosporin is accurately translated into the corresponding carbapenem. The resulting 1-oxocarbapenems (2) were selectively transformed through reduction into 1-oxygenated carbapenems and carbapenams (3 and 4, respectively). On microbiological screening, a carbapenem (3c) was found to possess a broad spectrum of activity. An interesting antibacterial profile was discovered for a carbapenam (26).

Anti-Bacterial Agents↗
PubMed1979

Predicting vocal frequency from selected physiologic measures.

Simultaneous physiologic measures were obtained on four young adult male subjects as they sustained phonation at seven frequencies within their modal-to-falsetto voice range. Data were analyzed using a multiple regression program to determine the contribution of each measure singly and in combination with other measures to the prediction of the resultant voice frequency. Results showed that by far the best predictor was cricothyroid muscle activity for both the pooled data model, and for each individual subject. The contribution of subglottal air pressure and thyroarytenoid muscle activity increased the variance explained by only 4% while the measure of vertical laryngeal position was a significant factor in only one subject's predictive model. Partial models from the pooled data explained from 67% to 73% of the variance; whereas the obtained measures for individual subjects explained from 90% to 94% of the variance.

Adult↗