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Biomedical subjects

P N Elliott

Publications and source records attributed to P N Elliott.

At least 19 recordsLinked to original sources
PubMed1986

Soluble asparaginase-dextran conjugates show increased circulatory persistence and lowered antigen reactivity.

Oxidized dextrans of increasing molecular weight were bound covalently to Erwinia carotovora asparaginase. The resulting conjugates retained 50% of their enzyme activity and showed marked resistance to proteolysis by trypsin and chymotrypsin and inactivation by asparaginase-specific antibody. When tested in-vivo, the larger molecular weight conjugates showed prolonged circulatory survival in both immune and non-immune animals and failed to elicit full type III hypersensitivity or anaphylactic reactions when injected into sensitized guinea-pigs. Rabbits could tolerate multiple doses of the asparaginase conjugate without developing an immunity to the enzyme. A conjugate showing increased circulatory half-life and lowered antigen reactivity should have therapeutic potential.

Animals↗
PubMed1975

Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate.

Acetylsalicylic acid (aspirin) and sodium salicylate are equally effective in reducing the swelling in the carrageenan-induced paw test and the accumulation of leucocytes into the inflammatory exudate produced by the subcutaneous implantation of polyvinyl sponges in the rat. Aspirin but not sodium salicylate caused a significant reduction in the potentiation of paw oedema found after the concurrent administration of carrageenan and arachidonic acid. Some implications of these findings are discussed.

Animals↗
PubMed1974

Anti-inflammatory and irritant effects of a fraction from normal human plasma.

1 By the use of carrageenan-induced rat paw oedema assay the anti-inflammatory activity of a fraction isolated from normal human plasma has been measured after its intravenous, intraperitoneal and oral administration. Its effects in the dextran-induced rat paw oedema and the systemic dextran anaphylactoid reaction in the rat were also studied.2 The fraction showed marked anti-inflammatory activity in the carrageenan test after intravenous administration and a smaller but still significant activity when given intraperitoneally, but was inactive orally after the administration of a larger dose. It was active in the dextran-induced paw oedema test but not against the anaphylactoid reaction.3 A comparison between its anti-inflammatory and irritant properties revealed no correlation when each parameter was determined in relation to dose. The fraction did not affect the blood pressure of the anaesthetized rat.4 These findings are discussed in relation to the existence of a natural anti-inflammatory substance or substances in human plasma.

Administration, Oral↗