Biomedical subjects
Publications and source records attributed to P N Krishnamurthy.
An 11 month old boy presented with gangrene of the extremities. He was found to have positive nuclear antibodies and antibodies to double stranded DNA, and negative Ro and La antibodies. The infant was started on oral prednisolone, which was discontinued after six months. At one year of follow up he was asymptomatic, with negative nuclear antibodies and antibodies to double stranded DNA.
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TAR syndrome is a rare inherited autosomal recessive disorder with a mortality rate of 30-40% mainly as a result of haemorrhage, in the first year of life. Most of the infants recover from the effects of thrombocytopenia and associated haematological complications with the modern medical care. Very rarely, the outcome is fatal, with the occurrence of acute leukemias.
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