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Biomedical subjects

P N Liubchenko

Publications and source records attributed to P N Liubchenko.

At least 19 recordsLinked to original sources
PubMed2006

[Markers of asbestos exposure in workers].

Examination covered 213 workers of asbestos technical ware plant. Standard X-ray examination no pulmonary and pleural changes were revealed. External respiration studies demonstrated moderate ventilation disorders in half of the examinees: in hardware workshop workers--restrictive type disorders, in autofriction components workshop workers--obstructive type ones with hyperventilation. Lower diffusing lung capacity in one-third of the workers in one of two autofriction components workshops proves most likely distributive disorders. Moderately increased serum alveolar mucin 3EG5 in 20% of the examinees could be a predictive criterion of slow formation of chisotyle pulmonary fibrosis.

Adult↗
PubMed2006

[State and prospects of evidence-based medicine and occupational pathology].

According to foreign literature data, contemporary methods of evidence-based medicine are insufficiently limited in use by occupational pathologists both in this country and abroad. This is due to restrictions of Occupational Diseases Register, difficulties in adding new entities into it, medical and social practice to use functional parameters for disablement definition, employers' obstacles to reveal early stages of occupational diseases through active employees' examinations, patients' wish to receive governmental annuity and not to get rehabilitated.

Attitude of Health Personnel↗
PubMed2006

[Principles of rehabilitation in major occupational diseases].

The article deals with personal experience and literature data, basing recommendations on rehabilitation of patients with occupational diseases. Rehabilitation measures include better work conditions, job placement of individuals in whom the disease was not caused by etiology factor, rehabilitation through medical and nonmedical measures.

Humans↗
PubMed2005

[Diagnostic value of needle electromyography in patients with occupational polyneuropathy caused by vibration and functional overstrain].

The authors determined diagnostic and differential value of needle electromyography in workers with occupational diseases of upper limbs. Results prove differences in neuromotor disorders of hands: vibration disease usually involves spinal motoneurons, whereas functional overstrain is characterised by marked muscular suffering (myopathy, myodystrophy).

Adult↗
PubMed2005

[Significance of laser dopplerometry in diagnostics of upper extremity occupational angiopathy].

The paper demonstrates the results of the application of laser dopplerometry supplemented with respiratory, thermal and occlusive functional tests, as a new non-invasive method of microcirculation evaluation. Initially the majority of patients have spastic or hyperemic microcirculation disturbances in the skin of the fingers. Functional tests allow specification of the mechanisms of these disturbances, such as microhemodynamic inertness and the suppression of slow circulatory rhythms, which demonstrate the presence of myogenic tonus disorder and prove that vibration has direct influence on vascular wall cells. The manifestation of neurogenic component is the dominance of sympatic vasomotor reflex. The paper also demonstrates the dominance of vasoconstrictor effect over vasodilatatory one.

Adult↗
PubMed2005

[A vasoregulating function of the major vessels of the upper limbs in patients with vibration disease].

AIM: To investigate a vasoregulating function of the endothelium of the upper limbs' major arteries in patients with vibration disease (VD); to determine VD role in pathogenesis of vascular disorders. MATERIAL AND METHODS: A total of 54 VD men free of cardiovascular disease (age 42.4 +/- 0.98 years) with mean occupational local vibration contact 19.4 +/- 1.12 years entered the study. Diameter of the brachial and radial arteries and hemodynamics in them were measured with triplex scanning of the vessels. Hemodynamics in smaller vessels was examined with dopplerography. A vasoregulating function of vascular endothelium was assessed with a postocclusion test with reactive hyperemia, cold and nitroglycerin tests on sites distant from the sites exposed to vibration and close to such sites. RESULTS: Abnormal endothelium-dependent responses at distal parts of the radial artery as marked vasoconstriction in the phase of ischemia and in response to cold, inhibition of systolic and volume speed of blood flow in reactive hyperemia were found. The strongest changes were seen in finger hand arteries. No disturbances of endothelium-independent reactions in nitroglycerin test were seen. CONCLUSION: Vascular disturbances in the action of local vibration on the workers' hands are explained not only by systemic impacts but also by local disorders of endothelial function of hand vessels.

Adult↗
PubMed2004

[Pneumoconiosis in contemporary changing world].

The authors summarize materials on features of pneumoconioses formation and treatment in contemporary production, on new pathogenetic mechanisms, methods of early diagnosis and treatment of pneumoconioses.

Dust↗
PubMed2004

[The cardiovascular system in liquidators of consequences of the Chernobyl atomic power station accident].

Liquidators of consequences of the Chernobyl atomic power station accident were found to have cardiovascular regulatory disorders in the late period. A late pressure reaction of systolic blood pressure to exercise was caused by cardiac rhythm rigidity due to the sick sinus syndrome. High exercise tolerance and delayed ischemia were indicative of diminished total peripheral resistance due to the impaired responsiveness of alpha-adrenoblockers in the arterial vessels and of the development of neurocirculatory dystonia. Cardiovascular functional changes in the liquidators are not attended by the higher morbidity rates of hypertensive disease.

Cardiovascular Diseases↗
PubMed2003

[The use of fermented milk drink with topinambur for the treatment of Helicobacter infection in the liquidators of Chernobyl nuclear power plant accident].

For estimation of anti-helicobacter activity of new fermented milk drink with Helianthus tuberosus called 23 liquidators of crash after-effects of Chernobyl Nuclear Power Plant were observed. Helicobacter pylori were determined in faeces by PCR-method, immune system readings--by first-level methods. The drink was applied in 200 grams portions during 18 days. After therapy appearance of Helicobacter pylori in faeces was reduced for 3 times. Reading of HCT-test, increased up to 16% in the first test before therapy, was normalized after therapy. Listed figures prove anti-helicobacter activity of fermented milk drink with Helianthus tuberosus.

Adult↗
PubMed2002

[B-mode ultrasonography scanning main arteries of upper limbs in vibration disease patients].

The objective was to use B-mode ultrasonography for assessing vascular walls of upper limbs main arteries in vibration disease patients. Imaging of the arterial walls revealed changes concerning increased intima-media complex (IMC). Ratio of IMC to vascular diameter was considerably higher in vibration disease patients--0.233 +/- 0.013 vs control value of 0.156 +/- 0.014 (p < 0.01). Vibration could result in destruction of some endothelial cells and significant release of endothelial growth factors.

Arm↗
PubMed2002

[Ultrasound characteristics of common carotid arteries in Chernobyl clean-up crew members long after the accident].

AIM: Detection of early atherosclerosis and some mechanisms of dyscirculatory encephalopathy development late after the Chernobyl accident. MATERIAL AND METHODS: 57 men (mean age 45.9 +/- 1.18 years) exposed to ionizing radiation after the Chernobyl accident in 1986-1987 (random sample) and 28 healthy men (control) entered the trial. Their examination included ECG, echocardiography, veloergometry (on demand), 24-h monitoring of arterial pressure and Holter monitoring, B-mode ultrasonic scanning in combination with dopplerography and color mapping of blood flow (triplex scanning) of the right and left common carotid arteries on the unit Vingmed CFM (Diasonic Sonotron, Germany) using 7.5 MHz sensor. Blood serum was examined for total cholesterol and triglycerides. RESULTS: Clinical manifestations of atherosclerosis--ischemic heart disease--were detected in 11 examinees (19.3%). Thickening of the complex intima-media which is thought an early marker of atherosclerosis was identified in 28 examinees (49.1%), stenoses and atherosclerotic plaques--in 17(30%) examinees. Three of them had hemodynamically significant stenoses. Increased blood flow in common carotid arteries combined with enhanced pump function of the left ventricle. CONCLUSION: Atherosclerotic vascular alterations detected in the Chernobyl wreckers were encountered 2 times more frequently than clinical symptoms of atherosclerosis. One of the mechanisms of dyscirculatory encephalopathy in them is high blood volume circulating in common carotid arteries in combination with left ventricular pump hyperfunction.

Adult↗