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Biomedical subjects

P N Prinz

Publications and source records attributed to P N Prinz.

59 records · Page 4Linked to original sources
PubMed1975

Age-dependent changes in hippocampal theta.

The hippocampal theta rhythm in rats exhibited an age-dependent slowing in modal frequency. However, the theta rhythm of young rats with chronic respiratory infections showed a similar slowing. Respiratory disease-free hamsters also exhibited an age-dependent slowing of modal frequencies. These findings emphasize that the health status of the animal must be examined carefully in order to establish an age-dependent slowing in hippocampal rhythm.

Age Factors↗
PubMedDate not supplied

Circadian temperature rhythms in young adult and aged men.

The core body temperatures of ten healthy young adult and eight healthy aged men were recorded continuously for 14-24 hours using rectal thermometers and analog tape recorders. Aged subjects had significantly higher temperatures at the nadir of the temperature curve compared to the young subjects. Cosinor analysis of the data revealed that, while all subjects' data significantly fit an idealized cosine function of 24 hours periodicity, the peak to trough amplitude of the rhythm was significantly lower in the aged group. No group differences in the 24-hour mean temperature, the mean temperature during the sleep period time, the mesor, or the acrophase were found. These data are in essential agreement with previously reported data but expand upon those findings and demonstrate that the age-related changes in amplitude of the temperature rhythm are not confined to subjects studied under isolated laboratory environments.

Adult↗
PubMedDate not supplied

Entrained body temperature rhythms are similar in mild Alzheimer's disease, geriatric onset depression, and normal aging.

Sleep-wake rhythms are known to be altered in Alzheimer's disease (AD) and in unipolar depression. Other evidence suggests that the circadian rhythm in body temperature may be altered as well. Entrained circadian temperature rhythms were measured in healthy elderly men and women, as well as in men and women suffering from unipolar depression or mild AD, to examine this possibility. There were no differences in the temperature rhythm characteristics of subjects with depression or AD compared with healthy control subjects. However, gender differences were observed. Female control subjects showed a larger amplitude, higher peak temperature, and earlier acrophase relative to male control subjects. Also, the mesor of female AD subjects was higher than for male AD subjects. These results are discussed in the context of the widely varying subject populations used in other studies.

Aged↗