Biomedical subjects

P Nash

Publications and source records attributed to P Nash.

At least 19 recordsLinked to original sources

PubMed1991

Acute Barmah Forest polyarthritis.

More than 60 arboviruses have been isolated in Australia with the human pathogenicity of the majority yet to be determined. Recent reports outline extensive clinical and sub-clinical infection occurring in Eastern Australia by such agents as Ross River and Barmah Forest viruses. We describe the clinical features of two patients with an acute polyarthritis associated with serological evidence of acute Barmah Forest virus infection to alert physicians to this form of viral polyarthritis and highlight the need to consider this agent when confronted with patients with an acute 'viral-type' polyarthritis in whom serology for Ross River virus is negative.

Acute Disease↗

PubMed1990

ABC of major trauma. Trauma in pregnancy.

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Abruptio Placentae↗

PubMed1990

A prospective double blind dummy placebo controlled study comparing triamcinolone hexacetonide injection with oral diclofenac 50 mg TDS in patients with rotator cuff tendinitis.

A prospective double blind placebo controlled study was carried out to compare the effects of subacromial injection of triamcinolone and oral diclofenac in patients with rotator cuff tendinitis over a 4-week period. Both forms of treatment were superior to placebo in reducing pain, improving active abduction and reducing functional limitation. Triamcinolone showed the greatest effect in these respects, and was significantly superior to diclofenac when patients showing improvements in all 3 variables together (responders) were considered.

Administration, Oral↗

PubMed1989

Frozen shoulder.

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Arthrography↗

PubMed1989

Chronic coxsackie B infection mimicking primary fibromyalgia.

We describe a patient with primary fibromyalgia according to Smythe's criteria who had evidence of chronic infection with Coxsackie virus over a 4-year period. We discuss the association of Coxsackie infection and myalgic syndromes and review the literature.

Aged↗

PubMed1988

The disposition of biphenylacetic acid following topical application.

Plasma and synovial fluid concentrations of biphenylacetic acid were determined following application of 3 g of 3% biphenylacetic acid gel to one knee of patients suffering from rheumatoid arthritis. The mean peak plasma concentration was 34 ng/ml. Synovial fluid concentrations tended to follow plasma concentrations but at a somewhat lower level, the mean peak synovial fluid concentration was 21 ng/ml. The average ratio of synovial fluid AUC (0-24 h) to plasma AUC (0-24 h) was 0.58, r = 0.97. Where patients had bilateral effusions, the concentration in the ipsilateral knee at each time point examined was not significantly different to that in the contralateral knee, suggesting that absorption was initially into the plasma and subsequently into the synovium.

Administration, Topical↗

PubMed1988

Trochanteric bursitis: bone scan appearance.

Trochanteric bursitis is one of the most common soft tissue abnormalities in the hip region, yet it is frequently underdiagnosed. There is a characteristic pattern of uptake seen on the bone scan in patients with this condition. Its recognition is important to avoid misinterpretation of increased trochanteric uptake, particularly in patients with malignant disease, and to aid in the diagnosis and effective management of this treatable condition.

Aged↗

PubMed1988

Vasculitis presenting as chronic unilateral painful leg swelling.

We describe 2 patients who presented with chronic painful indurated swelling of one lower limb, thought at the time of referral to be due to chronic venous insufficiency. Reassessment because of marked periostitis of the tibia and fibula as well as laboratory indices consistent with an inflammatory process revealed acute necrotizing arteritis in one patient and granulomatous arteritis in the other. Clinicians should be aware of this unusual presentation of treatable vasculitic diseases.

Aged↗

PubMed1987

Interstitial lung disease as the presentation of anti-Jo-1 positive polymyositis.

A patient presenting with interstitial lung disease was predicted to have underlying polymyositis when found to be anti-Jo-1 antibody positive. When myopathy developed later with elevated serum creatine phosphokinase and myoglobin levels, the electromyogram was nonmyopathic, and polymyositis was confirmed by muscle biopsy. The case illustrates the value of anti-Jo-1 as a 'marker' autoantibody for polymyositis, and the need for thorough investigation of patients with interstitial lung disease of uncertain etiology. This should include indirect immunofluorescence using a dividing cell substrate and tests for antibodies to extractable tissue antigens. The need to completely evaluate patients with dermatopolymyositis is also emphasised.

Aged↗

PubMed1987

Protection against fat cell hyperplasia in a hibernator, Glis glis.

Dormice, Glis glis, were fed a high-fat diet for 11 mo in one experiment: in another experiment they were fed a high-fat diet for 5 mo, either at room temperature (21.5 degrees C) or in a warm room (27 degrees C). Only in the latter group did adipocyte hyperplasia occur; this was significant in all the fat depots studied (inguinal, retroperitoneal, and gonadal). In the other groups there was no evidence of fat cell hyperplasia, despite weight gains from approximately 160 g (peaks on chow diet) to approximately 250 g (maximums on high-fat diet). Instead, fat cell size, assessed from biopsies of the inguinal area, became considerably enlarged. Taken together with earlier data from other species, the results suggest that hibernators are protected against fat cell hyperplasia. In dormice this protection appears to be present at all phases of their seasonal weight cycles. For species that experience several cycles of weight gain and loss in their lives, it may be adaptive to avoid increases in adipocyte number.

Adipose Tissue↗

PubMed1986

Peppermint oil does not relieve the pain of irritable bowel syndrome.

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Adult↗

PubMed1986

Calcification is rare in adult-onset dermatopolymyositis.

Extensive subcutaneous and muscular calcification developed in a patient having adult-onset dermatopolymyositis (DM-PM) with an 'overlap' connective tissue disease. We wish to emphasize the rarity of calcification in adult onset DM-PM, which is contrary to the generally held impression.

Adult↗

PubMed1978

Legionnaires' disease: structural characteristics of the organism.

The Legionnaires' disease organism was isolated from lung tissue taken from two fatalities of the Legionnaires' disease epidemic that occurred in Philadelphia during 1976. In yolk sac tissue the agent grew as a small coccobacillary microorgansim, which was Gram variable and Giménez positive. Intracellular coccoid and bacillary forms, detected by electron microscopy, within and without vacuoles, underwent multiplication by septate binary fission. Some of the intracellular forms resembled obligate intracellular pathogens. On defined bacteriologic media, the organisms were predominantly bacillary. The organism conforms to the morphologic criteria of a prokaryocyte.

Humans↗

PubMed1978