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Biomedical subjects

P Netter

Publications and source records attributed to P Netter.

At least 73 records · Page 4Linked to original sources
PubMed1988

Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis.

The risk-benefit ratio of combined fluoride-calcium therapy in primary vertebral osteoporosis was examined prospectively in patients with at least one vertebral fracture. 257 patients were randomised to receive sodium fluoride 25 mg twice daily plus elemental calcium 1 g daily and a vitamin D2 supplement, and 209 received one of the alternative therapies usually prescribed in France. After a follow-up of 24 months the fluoride-calcium group showed a significantly lower rate of new vertebral fractures, the main adverse effect of the regimen being a higher incidence of osteoarticular pains in the ankle and foot; the risk of non-vertebral fractures was not increased, and digestive disorders arose with equal frequency in the two groups. Sodium fluoride 50 mg daily seems to represent a reasonable compromise in terms of anti-fracture effectiveness and side-effects.

Administration, Oral↗
PubMed1988

[Joint complications in patients with chronic renal failure hemodialyzed for over 10 years. 40 cases].

A retrospective study of 40 patients with chronic renal failure who underwent haemodialysis for more than 10 years (mean: 153 months) showed that 18 patients (45 p. 100) had arthralgia in the shoulders, hands, wrists and knees, 13 (32 p. 100) had carpal tunnel syndrome requiring surgery, and 20 (50 p. 100) were found to have bone cavities in the humeral head, external supra-acetabular region, carpus and patella. Aluminium overload was present in 47 p. 100 of the patients, and amyloid deposits were found in 10 of the 12 patient operated upon for carpal tunnel syndrome. This study confirms the frequency in patients under long-term haemodialysis of an articular pathological entity consisting of arthralgia, carpal tunnel syndrome, juxta-articular bone cavities and amyloid deposits which are now known to be made of beta 2-microglobulin. The initial lesion seems to affect the synovial membrane; it appears to be facilitated by age and is often associated with aluminium overload. The mechanism(s) responsible for amyloid deposits remain (s) to be elucidated.

Adolescent↗
PubMed1988

Individual differences in benzodiazepine-induced changes of memory.

Antero- and retrograde amnesia are observed as side effects of most types of benzodiazepines. They have rarely been investigated with respect to physical and personality factors, or to prior experiences, present expectations, and emotional states of the subjects, all of which are well known to modify drug response. By reviewing research on benzodiazepine-induced changes of memory in preoperative, anxious, and depressed patients as well as in healthy subjects, it is demonstrated that differences in benzodiazepine-induced amnesic effects may depend on: 1. subject variables like predrug level of anxiety, depressive symptomatology, memory capacity, experiences with benzodiazepine-type drugs, and expectations of treatment outcome, and secondary factors like social environment and treatment setting 2. interactions between these subject variables and type of schedule (times of acquisition, treatment, and testing), type of learning material, and dose of drug. 3. the extent of benzodiazepine-induced changes in anxiety or depression, cortical and emotional arousal (alertness and activity) as well as physiological effects of benzodiazepines Special emphasis should be placed on the investigation of drug-induced changes of covariation between psychological measures which may provide valuable information for differential prediction and on mechanisms of drug action.

Anti-Anxiety Agents↗
PubMed1988

The effect of food on the systemic availability of ketoprofen.

We have studied the pharmacokinetics of ketoprofen, a non-steroidal anti-inflammatory drug, in 12 patients after a single 100 mg oral dose both in fasting conditions and with a meal. Food significantly affected the peak plasma concentration of ketoprofen and decreased its absorption rate. However, the extent of absorption of ketoprofen, as reflected by the area under the plasma concentration time curve, appeared to be unchanged in the presence of food.

Administration, Oral↗
PubMed1988

Effects of changes in brain 5-HT activity on indicators of cortical arousal.

Clinical studies on fluoxetine have reported occasional symptoms of increased fatigue in depressed patients. On the other hand, experimental studies in healthy subjects have demonstrated evidence for fluoxetine-induced increases in cortical arousal. The present placebo-controlled study with 24 healthy subjects was designed to answer the following questions: Does fluoxetine increase measures of cortical arousal and decrease feelings of alertness, and does the 5HT2 receptor blocker ritanserin produce inverse effects to fluoxetine? Analyses of covariance revealed the following results: Fluoxetine produced a slight increase, ritanserin a marked decrease in critical flicker fusion frequency. Time perception was slightly improved by both drugs. Self-ratings on alertness and energy were significantly reduced by both fluoxetine and ritanserin as compared to placebo. Effects for fatigue were increased accordingly. Possible underlying neurophysiological mechanisms and specificity of the effects for cortical as opposed to limbic arousal will be discussed.

Adult↗