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Biomedical subjects

P Neuzil

Publications and source records attributed to P Neuzil.

5 recordsLinked to original sources
PubMed2004

[Infectious endocarditis as a complication of cardiac pacemakers requiring emergency removal of the stimulating electrode].

Case report describes a patient with permanent pacemaker (implanted in childhood) who has developed infectious endocarditis with bacterial vegetation on the stimulation electrode while no febrile condition occurred and laboratory tests showed no inflammation. The course of the disease was affected by the previous inappropriate outpatient treatment of an infection in the suture after the pacemaker exchange. It should be noted that echocardiographic examination was essential for both the diagnostics and the choice of strategy. The therapeutic approach consisted of the combination of long-term antibiotic therapy and the explantation of the infected stimulation system. As it was not possible to accomplish by endovasal methods only, cardiosurgery for extraction of the lead was chosen.

Adult↗
PubMed2003

[Cardiac bradyarrhythmia ].

Permanent cardiac pacing was introduced in 1958 and till the end of 70s this method saved lives in particular of the patients with advanced atrioventricular block. The implantation technique has changed from complicated thoracotomy to endovasal approaches. The introduction of physiological AV sequenced atrioventricular pacing marked a significant progress in this field. Acute haemodynamic studies documented positive effect of the atrial contribution. Numerous studies subsequently analyzed the influence of different pacing regimes on total and specific cardiovascular mortality and morbidity. It can be concluded that on the basis of present evidence-based medicine the use of physiological pacing is clearly indicated in the patients with expressed sinus bradycardia and AV block of a higher degree. Atrial pacing remains an ideal solution for the patients with isolated sinus node dysfunction and sufficient atrioventricular conduction capacity. Research is continued in order to clarify how to influence the occurrence of ventricular fibrillation by permanent cardiac pacing including the use of preventive algorithms. This topic has not yet been reliably and unambiguously concluded. Biventricular pacing is currently established and recognized not only for typical indications in cases of bradyarrhythmias but also to solve primary haemodynamic problems in the patients with advanced heart failure and evidence of ventricular dyssynchrony.

Bradycardia↗
PubMed2002

An ISFET-based immunosensor for the detection of beta-Bungarotoxin.

An ion-sensitive field effect transistor (ISFET)-based immunosensor was developed to detect/quantitate beta-Bungarotoxin (beta-BuTx), a potent presynaptic neurotoxin from the venom of Bungarus multicinctus. A murine monoclonal antibody (mAb 15) specific to beta-BuTx was immobilized onto silicon nitride wafers after silanization and activation with glutaraldehyde. A chip based enzyme linked-immunosorbantassay (ELISA) was performed to ascertain antigen binding to the immobilized antibody. To develop an electrochemical immunosensing system for the detection/quantitation of beta-BuTx, an ISFET was used as a solid phase detector. MAb 15 was immobilized on the gate region of the ISFET. The antigen antibody reaction was monitored by the addition of urease conjugated rabbit anti-beta-BuTx antibodies. The sensor can detect toxin level as low as 15.6 ng/ml. The efficacy of the sensor for the determination of beta-BuTx from B. multicinctus venom was demonstrated in mouse model. Toxin concentration was highest at the site of injection (748.0+/-26 ng/ml) and moderate amount was found in the plasma (158.5+/-13 ng/ml).

Animals↗