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Biomedical subjects

P Neyra

Publications and source records attributed to P Neyra.

16 recordsLinked to original sources
PubMed1991

Kock pouch procedures: continuing experience and evolution in 135 cases.

Between April 1985 and January 1989, 135 consecutive patients underwent construction of a Kock pouch (to the skin in 72 patients, a urethral pouch in 45, an ileorectal pouch in 10 and a hemi-Kock pouch augmentation cystoplasty in 8). The operative mortality (30 days) rate was 4.4%. There were 16 early complications (12.4%) leading to 14 reoperations (11%), with a followup of 6 to 60 months. After Kock pouch to the skin, the late complication rate was 26.1% in the Kock-Skinner technique group and 7.4% in the simplified technique group, and 94.2% of the patients were continent. After a urethral Kock pouch daytime continence was achieved in 93% of the patients within 2 months and nighttime dryness was noted in 65% within 3 months. After an ileorectal Kock pouch all patients were continent day and night, as were those after hemi-Kock pouch augmentation, although 5 of the latter patients required intermittent catheterization.

Adolescent↗
PubMed1983

Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation.

The injection of neoprene into the pancreatic ducts of dogs has been used to destroy exocrine function prior to pancreatic transplantation. The subsequent histological changes and the evolution of lesions over a period of 3-36 months are described. Animals were sacrificed or biopsied at various intervals (3, 15 and 36 months) and the pancreases showed the disappearance of exocrine acini and changes of chronic pancreatitis. An immunoperoxidase procedure with insulin, glucagon, somatostatin and pancreatic polypeptide antisera was used to show the persistence of pancreatic endocrine cells. After the injections, sclerosis progressively increased and secondary lesions of the islets were seen, although functional islets persisted. This technique was then applied to pancreas transplantation in man. Eight transplants from seven diabetic patients were available for examination. In four cases, there were early technical failures, but four pancreatic transplants continued to function for 28-889 days until suppuration destroyed one of the grafts and the three other patients died. The persistence of endocrine cells in sclerotic tissue was observed in histological and immunopathological examinations.

Adult↗
PubMed1980

Successive appearance of carcinoma, tuberculosis and nephrolithiasis in a renal allograft.

A small renal cell carcinoma was transplanted inadvertently with a kidney from a living donor and was treated with partial nephrectomy. Secondarily, tuberculosis of the renal allograft appeared, which was followed by nephrolithiasis. The kidney was left in place, immunosuppressive treatment was continued and renal function is normal more than 8 years after transplantation, with no sign of the cancer progressing or reactivation of the tuberculosis.

Adenocarcinoma↗
PubMed1978

[A new method of pancreatic transplantation. II. Double renal and pancreatic transplantation in a diabetic with renal failure (author's transl)].

A 41-year-old man who had suffered from insulin-dependent diabetes since the age of twenty and who had severe degenerative complications with chronic renal failure, underwent pancreatic transplantation. The graft was prepared by intraduct injection of neoprene in order to suppress the exocrine function of the gland. It was situated in the iliac fossa and has ensured the complete correction of diabetes for more than 10 months. This favourable situation made it possible to carry out a renal transplant which could not have been envisaged previously in this patient with very unstable and progressive diabetes who was dialysed under very difficult conditions.

Adult↗
PubMed1978

[A new method of pancreatic transplantation. 1 - Effects on the dog pancreas of the intraduct injection of neoprene (author's transl)].

Injection into the pancreatic ducts of a synthetic liquid gum (neoprene), which polymerises when it comes into contact with the fluid secreted by the gland, would appear to be a simple and effective means of suppressing exocrine secretion of the pancreas in the dog. Endocrine secretion was remained in the short and mid-term. The therapeutic implications of this new technique in the preparation of pancreatic transplants are discussed.

Amylases↗
PubMed1978

A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man.

A new method of eliminating the exocrine function of the pancreas by obstruction of pancreatic duct with neoprene was investigated in dogs and applied to three cases of human segmental pancreatic transplantation. Neoprene is a liquid synthetic rubber which flocculates with changes in pH. In animals, progressive fibrosis of the pancreatic tissue occurs after injection of neoprene in the main pancreatic duct, leaving islets well vascularized and functioning for prolonged periods. Using this technique, three severely diabetic patients received a cadaver segmental pancreatic allograft. Blood sugar returned to normal levels within the first hours or days after operation. All three grafts continue to function 1.5, 2, and 8 months, respectively, following transplantation. If these results are confirmed by further clinical experience, this method may be of considerable assistance in the treatment of severe diabetes by pancreatic transplantation.

Adult↗
PubMed1977

Suppression of the exocrine function as an aid to of segmental pancreatic transplantation in dogs.

The injection of neoprene into the pancreatic ducts appeared to be a simple and effective means of suppression of the pancreatic exocrine function in dogs. It was investigated in experiments performed in three groups of dogs the pancreas of which were injected with 1 to 6 ml of neoprene. In group I (injection alone), all animals showed pancreatic exocrine insufficiency, none was diabetic. In group II, the dogs received a substitutive treatment and a special diet, they survived in a good general condition up to the time of sacrifice. There was extensive pancreatic fibrosis with disseminated Langerhans islets. In group III, a cephalic pancreatectomy was performed after the injection of neoprene into the pancreatic ducts, 8 animals were alive and well after 3 to 15 months, and showed a normal level of blood sugar, insulin, glucagon and amylase without glycosuria.

Amylases↗
PubMedDate not supplied

Surgical management of pelvic recurrence from resected rectal cancer: technical aspects.

Management of local-regional recurrences of primary rectal cancer (LRR) by a multi-disciplinary surgical team (GI, urological and plastic surgeons) is presented. Aggressive treatment involving surgical debulking and intra operative radiation can result in local control and long term survival in 10 to 20% of the patients with a low mortality and morbidity. Sequelae caused by the extended surgical resection are limited thanks to the fast healing following omentoplasty associated with musculo cutaneous flaps and to the fashioning of a continent stoma.

Combined Modality Therapy↗