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Biomedical subjects

P O Thune

Publications and source records attributed to P O Thune.

At least 19 recordsLinked to original sources
PubMed1990

[New aspects of the treatment of psoriasis].

Psoriasis is an inflammatory condition of the skin which affects about 2% of the population. Several new treatment modalities have been introduced in recent years. This review considers the mode of action of various forms of treatment, side effects and therapeutic results that have been observed. Etretinate is a synthetic vitamin A analogue. It works alone, or even better in combination with psoralen plus ultraviolet light A (PUVA) or ultraviolet light B (UVB). Cyclosporin is still on trial, but seems to be effective in small doses and can be considered as an alternative in cases of psoriasis that are resistant to other therapies. The interest in dietary measures for psoriasis has been revived after some studies have suggested that dietary supplements of fish oil, a low-fat diet, can improve the condition. Now that n-3-fatty acids are available in capsule form it should be possible to prescribe a diet that is rich enough in fish oils.

Cyclosporins↗
PubMed1988

Effect of dietary supplementation with n-3 fatty acids on clinical manifestations of psoriasis.

In a double-blind, block randomized study we investigated the effect of dietary supplementation with eicosapentaenoic acid in patients with psoriasis. The experimental group received 10 g of fish oil daily containing approximately 1.8 g eicosapentaenoic acid, while the controls were given an isoenergetic amount of olive oil. We found no significant change in the clinical manifestations of psoriasis in either group after 8 weeks of treatment. In the experimental group, the amount of n-3 fatty acids in serum phospholipids was significantly increased at the end of trial as compared to pre-treatment values, whereas the level of n-6 fatty acids was decreased.

Adolescent↗
PubMed1986

Epidermal and dermal distribution of a myelomonocytic antigen (L1) shared by epithelial cells in various inflammatory skin diseases.

The L1 antigen is a major cytosol component of human granulocytes that may also be expressed by macrophages and epithelial cells. Its epidermal and dermal occurrence was investigated in formalin-fixed routine biopsy material from eleven different inflammatory skin disorders. Localization was performed with a rabbit antiserum to L1 applied in an unlabeled antibody peroxidase-antiperoxidase method. L1 antigen was not found in normal skin except in epithelial cells of pilosebaceous units. However, epidermal L1 antigen was demonstrated in every biopsy specimen from lupus erythematosus, lichen planus, dermatitis herpetiformis, and atopic dermatitis, whereas granuloma annulare test results were usually negative. The occurrence of dermal L1 antigen depended on the composition of the inflammatory infiltrate; specimens rich in neutrophilic granulocytes (e.g., dermatitis herpetiformis) were particularly strongly stained. Extracellular dermal staining was also seen, especially in areas adjacent to accumulation of positive leukocytes. The varying epidermal occurrence of L1 antigen in skin diseases probably signified different degrees of proliferative activity of the epithelial cells and could apparently not be ascribed to uptake from the dermis.

Adolescent↗
PubMed1985

Skin and respiratory tract symptoms in veterinary surgeons.

Chronic or relapsing irritant eczema of the hands was the main complaint in 34 veterinary surgeons. 9 had contact allergic eczema of occupational character. In 8 cases, the allergies were probably due to antibiotics contaminating the skin during the administration of treatment. Contact allergy to penicillin was observed in 5 cases, to neomycin in 2 and to streptomycin in 1 case. Sensitivities to other work-related substances such as rubber chemicals, antiseptics and local anaesthetics were found in 6 cases. Multiple contact allergies, in particular to different penicillins, were seen frequently. Obvious work-related immediate reactions of probable allergic type were present in 10 cases, but were confirmed with positive RAST or prick test in only 2 cases.

Adult↗
PubMed1980

The effect of local UVB skin irradiation on the rate of formazan deposition in the epidermis of hairless mice studied by means of a tetrazolium-reduction method.

One-hundred-and-twenty hairless mice were irradiated with UVB (310 nm, exposure 60 mJ/cm2) on a limited area of the dorsal skin. At different time intervals after irradiation, the rate of endogenous dehydrogenase activity per mg dry epidermis was measured by the tetrazolium reduction method. The amount of formazan deposited remained normal for 18 h, and then increased, reaching a peak significantly higher than normal at 24 h, and thereafter returned to normal. At day 8 there was a new, probably significant peak. The reaction was followed for 14 days. It was concluded that UVB irradiation provokes a period of increased formazan deposition in the epidermis, similar to what has been observed after ionizing radiation and chemical carcinogens. The validity of the tetrazolium test for skin carcinogenic irritaments was thus also confirmed.

Animals↗
PubMed1980

Photosensitivity and allergy to aromatic lichen acids, Compositae oleoresins and other plant substances.

Sixteen patients with verified light sensitivity to both UVB and UVA wavebands showed allergic reactions to various lichen plants (Parmelia spp., Hypogymnia spp., Pseudovernia spp., Cladonia spp., Platismatia spp., Physcia spp., Umbilicaria spp. and Cetraria spp.). Among the aromatic lichen compounds, atranorin was observed to be the most frequently involved allergen, but also several other isolated lichen acids were immunologically active: d-usnic, evernic, stictic, fumarprotocetraric, lobaric, salazinic, diffractaic and physodic/physodalic acid. Several patients showed allergy to other plant substances from other sources such as seven different species from the Compositae family, alantolactone, balsam of Peru, colophony and wood tars. Sensitivity to known photosensitizers was observed in four patients. Aromatic lichen acids are UV-absorbing substances and several are evidently able to photosensitize human skin.

Cross Reactions↗
PubMed1980

Photosensitivity and allergy to aromatic lichen acids, Compositae oleoresins and other plant substances.

Sixteen patients with verified light sensitivity to both UVB and UVA wavebands showed allergic reactions to various lichen plants (Parmelia spp., Hypogymnia spp., Pseuodovernia spp., Cladonia spp., Platismatia spp., Physcia spp., Umbilicaria spp. and Cetraria spp.). Among the aromatic lichen compounds, atranorin was observed to be the most frequently involved allergen but also several other isolated lichen acids were immunologically active: d-usnic, evernic, stictic, fumarprotocetraric, lobaric, salazinic, diffractaic and physodic/physodalic acid. Several patients showed allergy to other plant substances from other sources such as seven different species from the Compositae family, alantolactone, balsam of Peru, colophony and wood tars. Sensitivity to known photosensitizers was observed in four patients. Aromatic lichen acids are UV-absorbing substances and several are evidently able to photosensitive human skin.

Acids↗
PubMed1979

Acid hydrolases in blister fluid. 5. Influence of ultraviolet radiation in patients with polymorphic light eruption.

The minimal erythema dose for chronic polymorphic light eruption (CPLE) patients was significantly reduced for UV-B rays. However, following doses which produced comparable erythema, no significant differences were found in the release of acid hydrolases between CPLE patients and controls. An increased release of acid hydrolases was found to accompany the formation of papular lesions. Increased enzyme activity was first observed some hours after the appearance of the erythema.

Adult↗
PubMed1979

Acid hydrolases in blister fluid. 6. Photocontact and contact allergic skin reactions.

Increased acid hydrolase activity has been demonstrated in the fluid from experimental suction blisters raised on the sites of contact or photocontact allergic skin reactions. The magnitude of the increases correlated well with the intensity of the reactions. The enzymes appeared after latent periods of 10 h for vesicular reactions, 15 h for papular reactions and 24 h for erythematous responses. The present observations are very similar to those reported following UV-B; thus our previous conclusions regarding the role of lysosomal hydrolases in UVR erythema may be generalized to include other forms of cutaneous inflammation.

Adult↗
PubMed1979

On erythema annulare centrifugum-type of psoriasis.

A case of EAC type psoriasis is reported. Routine and immunologic investigations were negative. HLA-B8 was found by typing. Some therapeutic benefit was achieved by combination of retinoid (Ro-10-9359) plus PUVA. According to a review of the literature half of the cases are unconnected to classical psoriasis, whereas the other half is connected and mostly of (periodic) pustular character. The necessity of clinical research in this intermediate type between psoriasis vulgaris and pustulosa is emphasized.

Diagnosis, Differential↗
PubMed1978

Urinary excretion of porphyrins in two cases of porphyria cutanea tarda during a period of various treatments.

The urinary excretion of porphyrins in two cases of porphyria cutanea tarda (PCT) has been followed during a period in which various treatments have been tried. In one patient pyridoxal-5-phosphate (P-5-P) injections lead to a dramatic increase in porphyrin excretion. In another P-5-P treatment was followed by a significant decrease in porphyrin excretion. p-Aminobenzoic acid (PABA) apparently had no effect on porphyrin excretion, while repeated phlebotomies had the expected effect. In both patients all variations in the total amount of porphyrins excreted were almost exclusively due to the variations in the amounts of heptacarboxylic porphyrin type III and uroporphyrin I. A secondary finding was an increase in hexa- and penta-carboxylic porphyrins type III without a concomitant increase in coproporphyrin III.

4-Aminobenzoic Acid↗
PubMed1977

Light sensitivity in mycosis fungoides.

Because of suspected photosensitivity, twelve patients suffering from mycosis fungoides have been phototested with various wavebands. Four patients experienced a burning sensation and erythema following sun-exposure, after the disease had progressed to stage II. On phototesting, abnormal reactions were observed in 7 patients. The offending wavebands were situated mostly in the UVA range, but also in the UVB range and in visible light.

Adult↗