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Biomedical subjects

P Onsberg

Publications and source records attributed to P Onsberg.

15 recordsLinked to original sources

Onychomycosis in patients with psoriasis.

The frequency and type of fungal infections of the finger- and toenails was studied prospectively by direct microscopic and culture examinations in dermatological out-patients without psoriasis (n = 41), in patients with psoriasis but no nail involvement (n = 39), and in patients with both psoriasis and nail involvement (n = 39). In these three matched groups the frequencies of dermatophytic nail infections were 10%, 13%, and 13%, respectively, and the frequencies of yeast infections 10%, 10%, and 15%, respectively. These figures were not significantly different. It is concluded that dermatophytic invasion of involved psoriatic nails is not so rare as previously supposed. However, yeast infections are possibly more frequent in involved psoriatic nails as compared with uninvolved and normal nails.

Humans↗

Scopulariopsis brevicaulis in nails.

Scopulariopsis brevicaulis was demonstrated in 226 out of 5,600 patients examined for abnormal toe-nails. Among 3,700 patients without onychomycosis S. brevicaulis was demonstrated as a contaminant in 2%. Onychomycosis, present in 1,925 patients, was caused by S. brevicaulis in 6%, but 10% of these cases were mixed infections with dermatophytes. In the approximately 1,800 cases of onychomycosis due to other reasons, S. brevicaulis was a contaminant in 2%. A specific finding of S. brevicaulis on direct microscopy is diagnostic, and a number of colonies greater than or equal to 10 supports the diagnosis, while in the presence of less than or equal to 3 colonies and no S. brevicaulis on direct microscopy the diagnosis is unlikely. Onychomycosis due to S. brevicaulis was most often diagnosed in elderly persons, with equal frequency in men and women.

Adolescent↗

Scopulariopsis onychomycosis treated with natamycin.

7 patients with Scopulariopsis brevicaulis onychomycosis of the toe-nails were treated locally with 1% natamycin in 60% dimethylsulphoxide. After 3-5 months treatment the fungus could no longer be isolated from the nails, and at follow-up 15 months after the completion of the treatment, 2 patients reported permanent improvement of the nails and 3 a complete cure. In 1 patient the treatment was ineffective.

Adult↗

Dermatophyte species, microscopic and cultural examination.

The dermatophytes Epidermophyton floccosum, Microsporum canis, Trichophyton mentagrophytes var. interdigitale, T. rubrum, and T. verrucosum were compared with respect to the direct microscopic examination of a clinical material and the number of colonies obtained by culture. It was found that the results of microscopy as well as of culture depended to a marked extent upon which species were the cause of the mycosis. The extremes were E. floccosum and T. mentagrophytes var. interdigitale which showed 7.5% and 32.5% isolates with negative microscopic findings and 45.5% and 5.0% isolates with larger than or equal to 10 colonies.

Arthrodermataceae↗

Human infections with Microsporum gypseum in Denmark.

Ninety cases of Microsporum gypseum infection in Denmark during the period 1933-1977 are reviewed. The sex ratio, age distribution, and anatomical sites are started. A case of onychomycosis in a 1-year-old child is reported, and the cases of M. gypseum onychomycosis in the literature are reviewed.

Adolescent↗

Human infections with Microsporum persicolor in Denmark.

The geographical and ecological spread of Microsporum persicolor is reviewed. It is concluded that M. persicolor is a zoophilic dermatophyte prevalent mainly in Europe and seldom reported as the cause of human infection. Twelve Danish cases of M. persicolor infection are described--their clinical features, mycological findings, and treatment. The localization of these fungal infections is reviewed on the basis of the present material and 58 cases from the literature.

Adolescent↗

Onychomycosis caused by Aspergillus terreus.

Four cases of onychomycosis caused by Aspergillus terreus are presented. The clinical characteristics consisted of spotted and striated leuconychia, dark spots and fragility of the nails. The mycology is described, and is shown that A. terreus has an inhibitory effect on the growth of dermatophytes and Scopulariopis brevicaulis. Topical treatment with 1% Pimafucin in a mixture of 60% dimethylsulfoxide (DMSO) and 40% water as well as 9% aqueous solution of sodium benzoate were both effective. The literature concerning onychomycosis caused by A. terreus is summarized.

Adult↗