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Biomedical subjects

P Osmanliev

Publications and source records attributed to P Osmanliev.

5 recordsLinked to original sources

[Clinical and laboratory studies of the hemorrhagic syndrome in hypo- and aplastic anemias].

Hemorrhagic manifestations were found in 142 (66.6%) out of 213 followed up patients with hypo- and aplastic anemia. Detailed clinical-laboratory study on the hemorrhagic syndrome was conducted in 58 of them. The hemorrhagic manifestations display a considerable polymorphism, being present both at the onset of the disease and its course. Changes in the laboratory tests were also found, associated mainly with thrombocytopenia. The tests, reflecting coagulation states, were most often normal. In four of the patients, hemorrhagia was due to disseminated intravasal coagulation. No correlation was found between granulocyte number and Factor VIII level.

Adult

[Study of the proliferative activity of the bone marrow cells in hypoplastic anemia and acute leukemia].

Autoradiographic investigations were carried out on bone marrow cells with thymidine H3 in patients with hypoplastic anemia and acute leukosis in hypoplastic phase. In all patients with hypoplastic anemia a considerable decrease of the labelled cells per cent was observed and in four of the patients in a period of exacerbation, two--in remission--no labelled cells were found. In patients with hypoplastic phase of acute leukosis the proliferative activity was absent. The injury of the bone marrow in case of hypoplastic anemia is supposed to occur at the different stages of hemopoesis.

Acute Disease

Respiratory function in iron deficiency anaemia before and after treatment.

The present studies concern the basic ventilatory indices, the arterial blood gases, the indices of the acid-base balance and the indices of the alveolar-capillary diffusion (DLCO, SS, Dm, theta Vc) in anemia before and after treatment. Substantial changes are recorded after treatment mainly in DLCO, SS and theta Vc. These changes are predominantly due to changes in the concentration of Hb. An evaluation of both methods for the standardization of DLCO at 14,6 g Hb/100 ml blood is also presented.

Adolescent