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P Otte

Publications and source records attributed to P Otte.

At least 19 recordsLinked to original sources
PubMed2002

[Ultrasound-guided puncture of the subclavian vein to implant central venous ports].

PURPOSE: To assess the safety and efficacy of ultrasound guided puncture of the subclavian vein instead of blind puncture or surgical procedure. The advantages compared with implantation of brachial ports are demonstrated. PATIENTS AND METHODS: In 41 oncologic patients the subclavian vein was punctured by ultrasound guidance in order to implant a port (34 left side, 7 right side). The study included 21 women and 20 men (range 34 - 79, mean 61 years). Imaging of the subclavian vein was performed with a 7,5 MHz linear ultrasound probe in B-mode and in colour doppler mode. Puncture was performed under ultrasound control (18 G, 45 mm needle when skin-vessel distance was < 3 cm, 19 G, 75 mm needle when skin-vessel distance was > 3 cm). In 27 patients a Bardport was implanted, in 14 patients a Vitalport (Cook). In three patients surgical port implantation failed. One of these patients had a partial thrombosis of the subclavian vein. RESULTS: Technical success was 100 %. In one patient we first punctured the subclavian artery at the beginning of our series without any complication. All port systems could be implanted. There was one haematoma in the port pocket without any effect to the port function. In the three surgical patients subclavian vein puncture and portimplantation was successful. CONCLUSION: Ultrasound guided puncture of the subclavian vein and port implantation by radiologists is a save procedure. A low risk approach to the subclavian vein is possible at any location. The long approach through the cubital vein with brachial port implantation is not necessary.

Adult↗
PubMed2002

Urinary excretion of N-methylhistamine as a marker of disease activity in inflammatory bowel disease.

OBJECTIVE: Mast cells are thought to participate in the pathogenesis of inflammatory bowel disease (IBD). In this study, urinary excretion of N-methylhistamine (UMH), a stable metabolite of the mast cell mediator histamine, was evaluated as an indicator of disease activity in patients with IBD. METHODS: Urinary excretion of UMH (microg/mmol creatinine x m2 body surface area) was measured by radioimmunoassay in 55 controls, 56 patients with Crohn's disease, and in 36 patients with ulcerative colitis. Excretion rates were correlated with clinical, serological, and endoscopic disease activity, disease extent, and location. RESULTS: Urinary excretion of UMH was found to be significantly elevated in IBD. Patients with active Crohn's disease (7.1 +/- 4.2, p = 0.002 vs controls) and active ulcerative colitis (8.1 +/- 4.8, p = 0.02 vs controls) had higher rates of UMH excretion than patients in remission (6.3 +/- 3.8 and 5.2 +/- 2.3, respectively) or controls (4.6 +/- 1.9). In Crohn's disease and ulcerative colitis, a significant correlation of UMH excretion with clinical disease activity was obtained (Crohn's Disease Activity Index r2 = 0.58, Clinical Activity Index r2 = 0.57, p < 0.0001). Serologically, orosomucoid showed the best positive correlation with disease activity (Crohn's Disease Activity Index r2 0.80, Clinical Activity Index r2 = 0.86, p < 0.0001), but UMH excretion was found to reflect disease activity more accurately than C-reactive protein (Crohn's Disease Activity Index r2 = 0.46, Clinical Activity Index r2 = 0.42, p < 0.0001). No association between UMH excretion and disease type or localization could be found in Crohn's disease. However, UMH excretion correlated strongly with endoscopic severity of inflammation in Crohn's disease (Crohn's Disease Endoscopic Index of Severity r2 = 0.70, p < 0.0001) or disease extent in ulcerative colitis. CONCLUSIONS: Urinary excretion of the histamine metabolite UMH is enhanced in IBD. It appears to represent an integrative parameter to monitor clinical and endoscopic disease activity in IBD, which appears to be influenced most likely by mediators released from histamine-containing cells, such as intestinal mast cell subtypes.

Adolescent↗
PubMed1996

Training influence on age-dependent changes in the gait of rats.

Stride length, stance width and gait symmetry were measured as parameters of gait analysis in young (5 months) and old (28 months) Sprague-Dawley rats following 3 months of treadmill running as well as in sedentary controls. Stride length decreased significantly with age and increased significantly following training in both young and old rats. Means of stance width increased significantly with age, but were unaffected by training. Gait symmetry declined with age; however, treadmill running counteracted the decline of gait symmetry. It was concluded that treadmill running compensates for or prevents age-related changes in the neuromuscular function of rats, which lead to gait deterioration.

Aging↗