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Biomedical subjects

P P Filatov

Publications and source records attributed to P P Filatov.

At least 19 recordsLinked to original sources
PubMed1987

[Secondary immunologic deficiency and its correction in cancer patients after radiation and combined therapy].

The problems of radiation immunology in oncological practice are discussed using, by way of example, studies on the effect of radiation and combined therapy on the state of the immunity system in some cancer types. The authors present data on the development of secondary immunodeficiency states determined by disorder in lymphocyte level, cooperation, enzymatic properties and function in immune reactions. A possibility of correction of secondary immunodeficiency states after radiation and combined therapy with the help of immunomodulators was shown.

Adjuvants, Immunologic↗
PubMed1983

[Prognostic significance of the determination of carcinoembryonic antigen in the blood of patients with lung cancer].

Correlation analysis of the results of examination of 86 lung cancer patients treated by surgery and methods other than surgery established an inverse relationship between life-span and carcinoembryonic antigen (CEA) level. An analysis using reagents supplied by CEA-IRE-Sorin Company showed that a CEA level in blood in excess of 10 micrograms/l is associated with the most unfavorable prognosis. The degree and rate of CEA excretion are in direct correlation with life-span and provide the most reliable criterion in evaluating the effectiveness of lung cancer treatment.

Carcinoembryonic Antigen↗
PubMed1982

[57Co-bleomycetin pharmacokinetics in the body of mice with LIO-1 lymphosarcoma].

Pharmacokinetics of 57Co-bleomycetin was studied on mice with lymphosarcoma LIO-1. It was found that at early periods of intravenous administration of the labeled antibiotic, i.e. within the period from 5 minutes to 1 hour its higher levels are detected in the liver, kidneys, blood serum, lungs, intestine and tumor. At later periods the drug levels in the organs and tissues gradually decrease and by the 72nd hour the concentration of 57Co-bleomycetin in the blood serum appears to be 30 times lower as that after 5 minutes. In the muscles and tumor its concentrations by that period are 15 and 2 times lower respectively. Radiometry of the animals showed that within the first 24 hours more than 85 per cent of 57Co-bleomycetin was excreted from the mice.

Animals↗
PubMed1982

[Antitumor activity and the effect on immunogenesis of combinations of rubomycin and carminomycin with levamisole].

The antitumor activity and effect on immunogenesis of rubomycin and carminomycin combinations with levamisole were studied comparatively. It was found that levamisole administered after carminomycin increased the intensity of delayed hypersensitivity in mice and only partially reduced immunoreactivity of the animals estimated by the number of antibody-forming cells in the spleen. No such effect was observed after injections of rubomycin. The antitumor effect of the combinations of the antibiotics wit levamisole was studied in experimental transplantable mouse lymphosarcoma L10-1. The use of rubomycin or carminomycin in combination with levamisole increased the survival of the animals and sometimes resulted in complete resolution of the tumors. No such effect was observed in treatment of the animals with the drugs alone. The data are indicative of a possible use of levamisole in combination with antitumor antibiotics in immunochemotherapy of tumors.

Animals↗
PubMed1980

[Effect of 57Co-bleomycetin on the immune response induced in mice by ram erythrocytes].

The effect of 57Co-bleomycin on the immune response induced by sheep red cells was studied on mice. It was found that the immune response was not suppressed when the labeled antibiotic was used in a single dose of 5-20 mg/kg. By the 5th day the level of 57Co-bleomycin in the skin, thymus and blood was 3-10 times higher than that of 57CoCl2 and in the spleen it was 1.3-1.5 times higher.

Animals↗
PubMed1978

[Carbon dioxide gas provoking and stopping an epileptic seizure].

The author discusses some mechanisms, conditioning the double role of carbon dioxide in the genesis of epileptical activity, first as a provocative factor, when carbon dioxide is a background against which the epileptical seizure appears and then as arresting the sequalae during the administration of CO2 during a seizure. It was demonstrated that the different action of CO2 was due to different phases in the changed functional state of the brain. The study was accomplished on 80 rabbits of the chenchille breed. The evalution of phases in changes of the functional state of the brain was performed with the aid of the encephalographic method.

Animals↗
PubMed1976

[Effect of the spleen extracts on primary immune response in mice].

Experiments were conducted on mice. Direct Jerne's test demonstrated a possibility of intensification of the primary immune response in the sexually mature mice under the effect of the splenic extracts. The significance of the extract dose and of the time of administration for the manifestation of the stimulating action was studied.

Animals↗
PubMed1975

[Pharmacokinetics of C14-olivomycin in the body of mice with lymphosarcoma (L10-1 strain)].

The pharmacokinetics of C14-olivomycin after its single intravenous administration to mice with lymphosarcome (LIO-I) was studied. It was shown that according to the specific radioactivity the organs may be placed in the following order: I hour after the antibiotic administration-the blood, liver, spleen, thymus, tumor, muscle; 3 hour after the administration-the liver, spleen, thymus, blood, tumor, muscle. Accumulation of olivomycin in the mouse organs was mainly in direct dependence on the dose of the antibiotic administered. Chromatography of the substances extraceted with ethylacetate from the urine collected at various periods after C14-olivomycin administration showed the presence of a new radioactive product (Rf 0.35-0.37) in addition to the unchanged antibiotic (Rf 0.53). Bioautographic analysis of the chromatograms showed that the product of C14-olivomycin conversion preserved its biological activity. The analysis of the substances extracted with ethylacetate from the liver, spleen and tumors 3 hours after the antibiotic administration reveiled (except of the liver) the presence of a spot with Rf corresponding to that of the initial drug.

Animals↗