ALLERGIC REACTIONS TO PENICILLIN.
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Biomedical subjects
Publications and source records attributed to P P VANARSDEL.
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With histamine release as an indicator, consistent passive sensitization of normal human leukocytes to specific anligen could be achieved with human serum, fresh or stored at -70 degrees C, from allergic individuals. With certain sera, dilution slowed the rate of sensitization but increased eventual histamine release.
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Some recent discoveries about the formation, storage and catabolism of histamine are reviewed. Histamine is formed by decarboxylation of histidine and stored principally in the mast cells of connective tissue. Human lung and facial skin are particularly rich in histamine. When histamine is injected intravenously, simulating spontaneous release, it is rapidly metabolized and excreted.
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