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Biomedical subjects

P Paluszkiewicz

Publications and source records attributed to P Paluszkiewicz.

8 recordsLinked to original sources
PubMed1999

[Single stab wounds causing multiple trauma].

The authors presented their two-year experience regarding diagnosis and treatment of 6 patients with single stab wounds causing polytrauma. In 4 cases the thoracoabdominal penetrating wounds were diagnosed. Emergency x-ray of the chest and ultrasonographic examination of abdomen were diagnostic in 1 case (17%). Five patients (83%) were operated in first three hours after trauma with good results. In 1 case (17%) delayed operation was complicated by left pyothorax. The results of this study indicated that patients with stab wounds causing polytrauma should be operated urgently in order to avoid complications and improve prognosis.

Adolescent↗
PubMed1999

[Extended small bowel resection with right hemicolectomy after massive superior mesenteric artery embolism, management in early postoperative period].

Intensive care management in recent postoperative period in nine patients with superior mesenteric artery embolism was provided. In all patients during surgical treatment an extensive resection of small bowel and right colectomy were performed. On the basis of physiopathological mechanisms of occlusional bowel ischemia and septic shock development the appropriate therapeutic procedure during pre and postoperative period was submitted. The authors suggest usefulness of the antibiotic prophylaxis in patients with high risk of measenteric embolism in order to decrease the dynamics of septic complications in the cases with bowel necrosis.

Adult↗
PubMed1998

[Antibacterial treatment in patients after extended bowel resection with ileo-cecal valve removal--personal experience].

Small bowel infection in patients that underwent extensional bowel resection is one of causal mechanisms of massive diarrhoea in postoperative period. The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR). From group of 21 patients that underwent EBR + ICVR the postoperative period survived only 11. In 9 cases massive diarrhoea and sepsis was observed. Routinely applied three-drugs antibacterial therapy based on penicillin or first-generation cephalosporin, aminoglycoside and metronidazole was efficient in 18% of patients only. The ciprofloxacin was used as a second-shot therapy in patients which did not realt on routine three-drugs antibacterial management. In all cases the clinical efficacy was observed as recessing of diarrhoea and septic symptoms. On the basis of our experience we suggest that in patients with massive diarrhea due to ascending contamination of small bowel after extensive resection with removal of ileo-coecal valve, ciprofloxacine is the treatment of choice.

Adult↗
PubMed1997

[P21-ras protein in tumors of the large intestine].

We carried out a prospective analysis of cytoplasmatic accumulation of p21ras protein-a Ki-ras gene product. The study was completed on the group of 80 patients with sporadic colorectal cancer. p21ras protein was detected immunohistochemically with use of NCC-001 antibody. In 64/80 cases (80%) we found p21ras protein accumulation in the tumor. We found that the protein accumulation is present more often in poorly differentiated cancers 91.3% (42/46) than in well and intermediate differentiated 64.7% (22/34) and in the right side of the colon 100% (14/14) than in left side colon 53.3% (14/24). The differences were statistically significant (p < 0.05). We found no statistically significant differences in survival time after surgery in correlation with p21ras accumulation in tumor. Our result suggest that p21ras accumulation is not a solitary prognostic factor in sporadic colorectal cancer.

Adult↗
PubMed1997

[The role of nm23 protein in progression of sporadic adenocarcinoma of the large intestine].

We analysed the nm23 protein expression in the selected group of 80 patients with sporadic colorectal cancer. nm23 protein was detected in cytoplasm with use of monoclonal anti nm23 antibody. Decreased expression of nm23 protein was found in 58/80 (72.5%) colorectal cancer samples. Positive reaction was found more often in the group A and B according to Dukes, than in the C and D. The difference was statistically significant at p < 0.05, and the occurrence was 75% vs. 15.63% respectively. We also found statistically significant difference in nm23 protein expression in well differentiated (G1) and poorly (G3) and intermediate (G2) differentiated. The positive reaction was observed in 85.71% in G1 group and 12.92% in G2 and G3 together. On the base of our study we suggest a usefulness of histochemical identification of nm23 protein expression in evaluation of metastatic potential of colorectal cancer.

Adenocarcinoma↗
PubMed1997

[P53 protein in adenocarcinoma of the large intestine].

P53 gen mutations play significant role in neoplastic transformation of colorectal mucosa. We investigated p53 immunostaining in 80 cases of spontaneous human colorectal adenocarcinomas (with monoclonal DO7 antibody and LSAB+ kit). We found positive, nuclear p53 immunostaining in 64% of nonmucinous adenocarcinoma tissues and in 19% of mucinous adenocarcinomas tissues. P53 protein deposits were most often found in colorectal adenocarcinomas localised in rectum (66.67%) and in advanced (Dukes C, D) colorectal adenocarcinomas (59.38%) as well. There was no statistical significance between the p53 positive immunostaining and the histological differentiation of the colorectal adenocarcinomas. The overall survival of patients with tumours positive for p53 protein was significantly shorter than that of patients with colorectal cancers negative for p53 protein. We conclude that p53 immunohistochemical analysis may be treated as a supplementary prognostic marker for patients with colorectal adenocarcinoma, especially it may be useful for adjuvant therapy selection.

Adenocarcinoma↗
PubMed1996

[Ileocolic intussusception].

A case of ileocolic intussusception in a 22-year female patient with ileocecal valve inflammatory process in presented. An absence of the acute gastrointestinal obstruction symptoms has been due to the inflammatory infiltration to the front of intussusception. Diagnostic problems in case of the intestinal intussusceptions in adults caused by non-characteristic clinical course have been emphasized.

Adult↗