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Biomedical subjects

P Paroussis

Publications and source records attributed to P Paroussis.

At least 19 recordsLinked to original sources
PubMed1989

Silicone oil implantation in penetrating injuries complicated by PVR. Results from 1982 to 1986.

Between 1982 and 1986, the authors implanted silicone oil in 34 eyes with retinal detachment and proliferative vitreoretinopathy (PVR) stages C-3 to D-3 caused by penetrating injuries. The retina had failed to reattach after initial vitrectomy, membrane peeling, and scleral buckling. Complete anatomic reattachment was achieved in 62%, partial reattachment in an additional 9%. Useful functional results were achieved in 68% of cases (visual acuity of 1/60 to 20/20). Postoperative complications included elevated intraocular pressure in 38% and progress of PVR with membrane formation under the silicone oil in 21% of the cases. Sixty-eight percent of the aphakic eyes developed band-shaped keratopathy. Because most of the eyes were aphakic, the authors do not report cataract incidence. In 15 eyes (44%) the silicone oil was removed. In 14 of these eyes the retina remains attached, in one eye silicone oil removal was followed by phthisis bulbi.

Eye Diseases↗
PubMed1988

Influence of indomethacin on PGE2 in rabbit aqueous humor after YAG laser photodisruption of the iris.

In an experimental study with rabbits, the influence of indomethacin on the postoperative PGE2 level in the aqueous humor was investigated, following YAG laser traumatization of the iris. Indomethacin is a drug with an inhibitory effect on the synthesis of prostaglandins. Using albino rabbits, the right eye was treated with indomethacin eye drops three times daily for 3 days. On the 4th day, high-energy YAG laser was applied to the iris of both eyes (Q-switched Nd: YAG Laser, Model Cilco Lasertek PV 135; ten photodisruptive lesions, with 50 mJ to the midperiphery of the iris). Subsequently, the rabbits were subdivided into three groups. In group 1 the aqueous humor was removed from both eyes 12 h postoperatively; in group 2 the aqueous humor was tapped 36 h after the intervention; for group 3, it was 60 h afterwards. The results from 15 rabbits were evaluated. Local indomethacin treatment was continued until tapping of the aqueous humor. As a control, another group was used with 3 rabbits without treatment. Twelve hours after YAG laser treatment there was still a clearly significant difference in the PGE2 concentrations between the eyes that had received indomethacin and the untreated eyes; 36 h postoperatively, the difference was no longer statistically significant, and after 60 h the PGE2 concentrations of the treated and untreated eyes were the same.

Animals↗
PubMed1987

Effect of indomethacin on aqueous PGE2 levels in rabbits following ocular trauma.

Using a highly specific radioimmunoassay, post-traumatic aqueous PGE2 levels were measured in rabbit eyes treated with topical indomethacin aqueous solution, as well as in untreated eyes. In two groups of ten rabbits each, the surgical trauma consisted of corneoscleral incision (without injury to the iris); one of the two groups received prophylactic treatment (3 days) and therapeutic (21 days) indomethacin treatment. In two other groups of ten rabbits each, corneoscleral incision and iridectomy were performed. One group received indomethacin treatment as described above, while the other group was not treated. Surgery was performed in all 40 right eyes, the left eyes serving as controls. In 20 of the 40 left eyes, indomethacin therapy was applied. In all right and left eyes, aqueous samples were withdrawn 3 days and 21 days postoperatively, and PGE2 concentrations were determined. The results indicate that 3 days after corneal trauma and 3 days after corneal trauma plus iridectomy, there was a highly significant reduction in the elevated PGE2 concentrations as a result of indomethacin therapy. On postoperative day 21, indomethacin reduced even further the still slightly elevated aqueous PGE2 concentrations without, however, completely blocking prostaglandin activity. The latter was observed even in the control animals that were not operated upon; they showed minimal PGE2 levels in response to corneal puncture on postoperative day 3 for the purpose of drawing aqueous samples. Our study demonstrated that short-term indomethacin therapy has a significant inhibitory effect, but no unequivocal answers were found as to the value of long-term treatment.

Animals↗
PubMed1987

Trabeculectomy and intraocular lens implantation: a combined procedure.

We present the results achieved in 26 cases of trabeculectomy combined with intraocular lens implantation after extracapsular surgery in eyes with open-angle glaucoma. Phacoemulsification was performed in nine cases, planned extracapsular cataract extraction in 17. In 23 eyes, a posterior chamber lens was implanted; in three eyes an anterior chamber lens was used because of a ruptured posterior capsule. After a follow-up period ranging from four to 29 months, the postoperative results were satisfactory in all eyes treated. The patients achieved postoperative intraocular pressure of 20 mm Hg or less. In 28% of the cases, however, additional antiglaucomatous medication is required. Given proper indications and present-day surgical techniques, this combined procedure provides effective one-time treatment for cataract and glaucoma patients as well as optimal visual rehabilitation.

Aged↗
PubMed1987

[Initial experiences with primary silicone oil administration into the vitreous cavity in complicated eye injuries].

The authors report on five cases of severe perforating injury of the posterior segment which were initially treated by vitrectomy and subsequent filling of the vitreous cavity with silicone oil. The results so far have been satisfactory in all eyes. The advantages of the method (e.g., tamponade of retinal tears, facilitation of postoperative laser treatment) are emphasized and possible side effects are discussed.

Eye Foreign Bodies↗
PubMed1987

High-energy electrons used to inhibit experimental intraocular proliferation and detachment.

Irradiation of rabbit eyes with high-energy electrons was used to test the inhibition of experimental intraocular proliferation and retinal detachment, produced by intravitreal implantation of 250,000 homologous fibroblasts. After irradiation with 2,000 rad, started 5 days after implantation, 45% of eyes (9 of 20) still manifested traction detachment. When the dose was increased to 3,000 rad and radiation treatment was started 1 day after implantation, proliferation and traction detachment were observed in only 10% of eyes (2 of 20). No acute damage to retinal tissue or nerve fibers was observed. Because it is easily available, simple in application and dose adjustment, and without toxic side effects, radiation therapy should be considered as an effective alternative to drug treatment for the inhibition of intraocular proliferation and detachment. Statistically significant results of this investigation suggest its use combined with surgery in certain reproliferative cases in man.

Animals↗
PubMed1986

[Cyanoacrylate tissue gluing in corneal perforations].

Three cases of corneal perforation which were treated with tissue adhesive (Histoacryl) are reported. The first case showed free fistulation after perforating keratoplasty, whilst the second had a trophic ulcer and the third had a traumatic corneal laceration with loss of corneal tissue. Treatment was successful in all three cases. The surgical technique, results and possible complications are mentioned.

Adult↗
PubMed1986

An intraocular balloon for silicone oil implantation.

This study reports 14 patients who presented proliferative vitreoretinopathy (PVR) at stages III to IV, as well as ora dialysis or large retinal breaks of such extent that it was evident that implanted silicone oil would penetrate behind the retina. We used a latex balloon catheter, which was introduced in aphakic eyes into the vitreous cavity, following pars plana vitrectomy and removal of pre- and sometimes subretinal membranes. Under direct observation, the balloon was filled with silicone oil until the balloon occupied the entire globe while the intravitreal and subretinal fluid was drained. Subsequently, the balloon was punctured at the opposite side of the scleral incision so that the silicone oil could drain into the vitreous cavity. The balloon was then slowly withdrawn from the eye. Complications were pre- and subretinal hemorrhages, retinal dialysis behind (2X) and vis-à-vis (4X) the incision. In none of the cases was silicone oil observed to have penetrated behind the retina.

Drug Implants↗
PubMed1986

[Argon laser trabeculoplasty in simple glaucoma].

In June 1984 the authors started a prospective study on the treatment of open-angle glaucoma with argon laser trabeculoplasty. The technique used was to treat 180 degrees of the anterior nonpigmented part of the trabecular meshwork with 80 to 100 burns. For retreatment the posterior pigmented part of the trabecular meshwork was coagulated with 80 to 100 burns. The burns were always applied to the pretreated half of the meshwork. At present the study includes 47 eyes treated posteriorly. Of these cases 12 eyes required retreatment. Five eyes had previously undergone an unsuccessful trabeculectomy. The preliminary results are satisfactory. The average reduction in intraocular pressure was 5.9 mm Hg; the mean intraocular pressure before therapy was 23 mm Hg. In 8 cases the trabeculoplasty failed, making a fistulating procedure necessary. The treatment was always well tolerated and there were only minor side effects which never led to any lasting damage.

Adult↗
PubMed1986

[Temporary silicone oil implantation following vitrectomy in proliferative diabetic retinopathy].

Report on 23 patients with proliferative diabetic retinopathy who underwent silicone oil implantation due to recurrent intravitreal hemorrhages following pars plana vitrectomy. Postoperatively, it was possible to perform panretinal laser photocoagulation without difficulty or haste. After an average period of 4 months, silicone oil was removed from 10 eyes. Subsequent hemorrhages in 4 of these eyes are due to diabetic retinopathy, not to silicone oil. In 6 cases, silicone oil removal is planned for the near future; in a further 7 cases, silicone oil removal has been postponed because of the potential danger of further traction retinal detachment.

Diabetic Retinopathy↗
PubMed1985

[Results after planned extracapsular cataract extraction with the Klöti stripper and implantation of UV light-absorbent Simcoe lenses with a 10-degree loop tilt].

Planned ECCE remains a valuable alternative to phacoemulsification due to its protection of the endothelial cells of the cornea. In contrast to the most commonly used infusion-aspiration systems, Kloeti's vitreous stripper provides, in addition, an excellent cutting mechanism enabling the removal of hard parts of the parenchyma or capsular remnants. The aspheric shaped UV light absorbing Simcoe lenses with a 10 grade loop angle used as lens replacement over the past 2 years in 300 cases did not cause any noteworthy complications. In 94% of cases a visual acuity of at least 0.5 was achieved; no case of cystoid macular edema has been observed so far.

Cataract Extraction↗
PubMed1985

[Treatment of cystoid macular edema after intracapsular cataract extraction and implantation of the Binkhorst 4-loop lens].

This paper presents a report on 8 eyes in which cystoid macular edema developed between 6 months and 3 years after intracapsular cataract surgery combined with 4 loop lens implantation. Topical indomethacin treatment undertaken for at least 3 months proved ineffective. In view of additional progressive damage to the inferior part of the iris due to the inferior lens loops as well as recurrent microhaemorrhages in the anterior chamber, the iris clip lens was removed and after thorough anterior vitrectomy with Kloeti's stripper a Shepard anterior chamber lens was implanted. Indomethacin treatment 3 to 4 times daily was continued postoperatively for up to 8 months. Evident improvement in visual acuity was noted in 5 eyes, whilst in the remaining 3 eyes the procedure had probably been carried out too late.

Aged↗
PubMed1985

[Posterior chamber lens implantation after removal of an intralens metallic foreign body].

This paper presents a case report of posterior chamber lens implantation after a perforating eye injury. We failed to extract the foreign body with a hand magnet and to close the capsule wound by application of a fibrin tissue adhesive. The posterior capsule was intact, and hence we performed an extracapsular cataract extraction with implantation of a posterior chamber lens. The foreign body was expressed together with the nucleus. The functional result is satisfactory.

Anterior Chamber↗
PubMed1985

[Immunosuppressive therapy with cyclosporin A following penetrating keratoplasty].

Report on 11 patients who underwent penetrating keratoplasty and were treated with Cyclosporin A for an average of 6 months because of excessive superficial and deep vascularization of the recipient cornea. In none of the patients was a permanent Cyclosporin A-induced side-effect observed. After an average follow-up period of 11 months 9 grafts remained completely clear; however, an allograft-reaction occurred in 2 cases in spite of the immunosuppressive therapy.

Corneal Diseases↗
PubMed1985

[Change in corneal refractive power following artificial lens implantation].

Report on the changes in the corneal refractive power of 284 eyes surgically treated for cataract, in which an IOL had been implanted. The mean corneal refractive power of the eyes was 43.31 +/- 1.43 D preoperatively and 43.39 +/- 1.46 D postoperatively (16th week). The postoperative astigmatism of 215 eyes in which a PCL had been implanted after ECCE was not higher than 1.1 +/- 1.1 D in the 16th postoperative week after selected removal of the nylon sutures. This study demonstrates that there is no statistically significant change in the mean corneal refractive power after cataract surgery with IOL implantation.

Astigmatism↗