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Biomedical subjects

P Paterson

Publications and source records attributed to P Paterson.

8 recordsLinked to original sources
PubMed1989

Is the treatment of urgency incontinence a placebo response? Results of a five-year follow-up.

The treatment and symptomatic outcome were reviewed in 50 women who had presented with urgency incontinence as their main symptom 5 years previously. All had idiopathic urgency incontinence and, on the basis of urodynamic investigation, 40 were considered to have detrusor instability and 10 sensory urge incontinence. The results indicate that the natural history of sensory urgency is one of spontaneous resolution; all treatments of detrusor instability (including surgery) produced an unsustained short-term symptomatic response. This pattern of response to therapy may be interpreted as being largely of a placebo nature and this emphasises the need for long-term follow-up in the assessment of new treatment modalities.

Adolescent↗
PubMed1987

What proportion of couples undergoing unrestricted in vitro fertilization treatments can expect to bear a child?

A 200-patient cohort has been established so that longitudinal analysis can determine the likelihood of an individual in vitro fertilization (IVF) entrant achieving a viable uterine pregnancy or a live baby. After a minimum of 39 months of access to repeated treatment cycles, 24% have achieved at least one viable pregnancy by undergoing an average of 2.48 treatment cycles per cohort member. Life-table analysis shows that most of these pregnancies have occurred in the first year after entering the program. Many members have undergone only one or two treatment cycles. In the future, greater emphasis will need to be placed on factors which encourage couples to undergo additional cycles of treatment. This, as much as technical advances, may increase outcome figures.

Actuarial Analysis↗
PubMed1987

Activation of 2-amino-3-methylimidazo (4,5-f) quinoline in rat and human hepatocyte/Salmonella mutagenicity assays: the contribution of hepatic conjugation.

The capacity of human liver S9 and hepatocytes to metabolically activate 2-amino-3-methylimidazo (4,5-f) quinoline (IQ) in Salmonella mutagenicity assays more closely resembles that of preparations from Aroclor-induced rat than control rat. The extent to which hepatocyte conjugating enzymes contribute to activation in these assays has been studied. Omission of sulphate or addition of a 'specific' sulphotransferase inhibitor (2,6-DCNP) did not significantly reduce mutagenicity, nor did PAPS enhance S9-mediated bacterial mutagenicity. Conversely, mutagenicity was significantly inhibited by PCP (an inhibitor of both sulphotransferase and acetyltransferase) and an acetylation-deficient Salmonella (TA98/1,8DNP6) was unresponsive to the mutagenicity of IQ. These data suggest that acetylation but not sulphation is important in IQ bacterial mutagenesis. The addition of acetyl CoA, PAPS-generating system or ATP paradoxically reduces the mutagenicity of IQ in S9/Salmonella TA98 assays. Therefore, activation by esterification in hepatocytes does not contribute to the mutagenicity of IQ in Salmonella typhimurium possibly due to restricted access of conjugates into the bacterial cell.

Animals↗
PubMed1978

Tubal microsurgery--a review.

Microsurgery is being applied with considerable advantage to tubal reconstruction, particularly in relation to improved pregnancy rates. These results justify the additional costs in equipment and time which are required.

Animals↗
PubMed1978

Microvascular transplantation of the human fallopian tube.

An unsuccessful human fallopian tube transplant is reported. A microsurgical technique is described which initially secured a viable transplant. However, the allograft subsequently died, probably as a result of rejection. Immunosuppression of the patient caused no complications or difficulties, the donor sharing one HL-A haplotype with the patient. The operative procedure, the risks of immunosuppression, and the ethical aspects of the case are discussed in order to present the problems associated with fallopian tube transplantation.

Fallopian Tubes↗
PubMed1977

Microsurgical tubal anastomosis for sterilization reversal.

A series of patients requesting sterilization reversal has been reviewed. Microsurgical tubal anastomosis has been successfully employed and offers improved surgical results. Minimization of the length of tube damaged at sterilization procedures is probably a major factor in determining pregnancy rates should subsequent reversal be desired.

Fallopian Tubes↗