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Biomedical subjects

P Pattison

Publications and source records attributed to P Pattison.

15 recordsLinked to original sources

Individual characteristics are less important than event characteristics in predicting protected and unprotected anal intercourse among homosexual and bisexual men in Melbourne, Australia.

OBJECTIVE: To describe individual, social network and encounter specific factors associated with protected anal intercourse (PAI) and unprotected anal intercourse (UAI). METHODS: This was a cross sectional survey conducted between April and November 2002. A total of 733 sexual encounters were reported by 202 men recruited from the gay community in Melbourne, Australia. Predictors of self reported PAI and UAI were examined. RESULTS: Of the 733 sexual events most (56.3%) did not involve anal intercourse, and more involved PAI than UAI (30.6% versus 13.1%). PAI was more likely than no anal intercourse (NAI) if the participant's social network was mostly homosexual, the partner was an occasional or casual partner, or was HIV positive. PAI was less likely if sex took place at a "beat" but more likely if it took place at a sauna. PAI was more likely if the partner was affected by drugs or alcohol. UAI was more likely than NAI if the participant had injected drugs in the year before interview. It was less likely if the partner was occasional or casual or was HIV positive but more likely if the partner's HIV status was unknown. UAI was much more likely than NAI if the encounter took place at a "sex on premises" venue. CONCLUSIONS: In this analysis it is the characteristics of the sexual encounter that predict whether PAI or UAI rather than NAI takes place.

Adolescent↗

Associations between the sexual behaviour of men who have sex with men and the structure and composition of their social networks.

OBJECTIVE: This exploratory study identified associations between the number of sexual partners reported by men who have sex with men (MSM) and the structure and composition of their social networks. METHODS: A cross sectional survey was conducted of men recruited as key informants, through advertising and chain referral. A face to face interview was conducted with 206 MSM. The interview included information on the number of sexual partners in the previous year and sociodemographic and behavioural characteristics of the participant. Social networks were enumerated and network size and density were calculated. Ordered logistic regression was used to assess the associations between number of sexual partners and personal and network characteristics. RESULTS: The number of anal sex partners reported was higher if the participant had injected drugs in the past year rather than never having injected (odds ratio, 95% confidence interval: 3.23, 1.28 to 8.15), decreased with network density (0.014, 0.002 to 0.008) and increased if the network did not comprise only HIV negative people (1.77, 1.05 to 2.99). The number of additional oral sex partners increased with network size (1.06, 1.02 to 1.10) and decreased with increased network density (0.034, 0.006 to 0.205). In addition to similar effects of network size (1.05, 1.01 to 1.09) and network density (0.086, 0.013 to 0.563) the model for the number of additional manual sex partners also included age (1.03, 1.01 to 1.05). CONCLUSION: The density of the social networks of MSM appears strongly and consistently associated with patterns of sexual behaviour. This underlines the importance of using network approaches to understanding the sexual behaviour of MSM and their potential value in identifying novel strategies for intervention.

Adult↗

N-Z-Pro-D-Leu using synchrotron radiation data from a very small crystal.

The crystal structure of the neuroactive artificial dipeptide N-benzyloxycarbonylprolyl-D-leucine, C(19)H(26)N(2)O(5), was solved using synchrotron radiation data collected on a very small crystal (20 x 20 x 380 microm). The molecules form hydrogen-bonded 2(1) helices. The acid carbonyl group does not participate in strong hydrogen bonds. This is interpreted as a consequence of close-packing requirements.

Crystallography, X-Ray↗

Reduction of dioxygen by a dimanganese unit bonded inside a cavity provided by a pyrrole-based dinucleating ligand.

A novel class of dinucleating ligands has been introduced into manganese chemistry to study the reactivity of this metal towards dioxygen under strictly controlled conditions. Such N4 ligands combine some of the major peculiarities of tetradentate Schiff bases and the porphyrin skeleton. They are derived from the condensation between 2-pyrrolaldehyde and ethylenediamine or o-phenylenediamine, leading to pyrenH2 (LH2, 1), pyrophenH2 (L'H2, 2) and Me2pyrophenH2, (L"H2, 3), respectively. Their metallation with [Mn3-(Mes)6] (Mes = 2,4,6-trimethylphenyl) led to [Mn2L2] (4), [MnL'(thf)2] (5) and [MnL"(thf)2] (6). Complex 4 displays a double-stranded helical structure, while 5 and 6 are mononuclear complexes containing hexacoordinated metals. Regardless of their structure, complexes 5 and 6 behave in a similar manner to 4 in their reaction with dioxygen, namely, as a dimetallic unit inside a cavity defined by two dinucleating ligands. These reactions led to dinuclear MnIII/MnIV oxo-hydroxo derivatives, [Mn2L2(mu-O)(mu-OH)] (7), [Mn2L'2(mu-O)(mu-OH)] (8) and [Mn2L"2(mu-O)(mu-OH)] (9), in which the two Mn ions are strongly antiferromagnetically coupled [J = -53 (7), J = -64 (8), J = -60 cm(-1) (9)]. The crystal structure of 7 could only be solved with synchrotron radiation as the crystals diffracted very poorly and suffered from twisting and disorder. The formation of 7-9 has been proposed to occur through the formation of an intermediate dinuclear hydroperoxo species.

Journal Article↗

Rapid characterization of complex structural phase transitions using powder diffraction and an area detector.

The use of a high-intensity and well collimated X-ray beam from a third-generation synchrotron source, combined with an area detector with online readout capabilities, allows high-quality powder patterns to be obtained with exposure times of only a few seconds. Powder measurements of a rare-earth manganate perovskite (Nd(0.43)Sr(0.57)MnO(3)) were performed in the temperature range 105-200 K, and the data were of sufficient quality to be able to extract, via Rietveld refinement, accurate values for the lattice constants and atomic parameters. The temperature dependence of the Mn-O-Mn bond angles and Mn-O distances obtained in this manner illustrate the well known correlation between the distortion of the MnO(6) octahedra and the onset of orbital ordering. The success of this study, for which only two hours of synchrotron beam time was required, indicates the enormous improvements in efficiency and throughput which area detectors are bringing to powder diffraction experiments.

Journal Article↗

Statistical Evaluation of Algebraic Constraints for Social Networks.

A multirelational social network on a set of individuals may be represented as a collection of binary relations. Compound relations constructed from this collection represent various labeled paths linking individuals in the network. Since many models of interest for social networks can be formulated in terms of orderings among these labeled paths, we consider the problem of evaluating an hypothesized set of orderings, termed algebraic constraints. Each constraint takes the form of an hypothesized inclusion relation for a pair of labeled paths. In this paper, we establish conditions under which sets of such constraints may be regarded as partial algebras. We describe the structure of constraint sets and show that each corresponds to a subset of consistent relation bundles between pairs of individuals. We thereby construct measures of fit for a given constraint set. Then, we show how, in combination with the assumption of various conditional uniform multigraph distributions, these measures lead to a flexible approach to the evaluation of fit of an hypothesized constraint set. Several applications are presented and some possible extensions of the approach are briefly discussed. Copyright 2000 Academic Press.

Journal Article↗

N-methyl-DL-aspartic acid monohydrate.

The title compound, C(5)H(9)NO(4).H(2)O, has been synthesized and crystallized. It crystallizes in Cc with one molecule in the asymmetric unit. The compound is found in its zwitterionic form. D and L forms of the compound are linked in the crystal via O-H...O and N-H.O hydrogen bonds, both directly between the aspartic acid-derivative entities and to the crystal water molecule. A weak intramolecular N-H...O interaction is found. The carbon skeleton is slightly twisted with C-C-C-C = 166.83 (11) degrees. A comparison with other derivatives of aspartic acid shows only two rotamers--one with a near planar carbon skeleton and one with a significantly twisted carbon skeleton.

Crystallography, X-Ray↗

The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.

The gene encoding the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase of Haemophilus influenzae has been cloned and expressed in Escherichia coli. A complex of the purified protein with a substrate analog has been crystallized and its structure solved by multiple anomalous dispersion using phase information obtained from a single crystal of selenomethione-labeled protein. The enzyme folds into a four-stranded antiparallel beta-sheet flanked on one side by two alpha-helices and on the other by three consecutive alpha-helices, giving a novel beta1alpha1beta2beta3alpha2beta4alpha3alpha4alpha5 polypeptide topology. The three-dimensional structure of a binary complex has been refined at 2.1 A resolution. The location of the substrate analog and a sulfate ion gives important insight into the molecular mechanism of the enzyme.

Adenosine Triphosphate↗

Logit models and logistic regressions for social networks: II. Multivariate relations.

The research described here builds on our previous work by generalizing the univariate models described there to models for multivariate relations. This family, labelled p*, generalizes the Markov random graphs of Frank and Strauss, which were further developed by them and others, building on Besag's ideas on estimation. These models were first used to model random variables embedded in lattices by Ising, and have been quite common in the study of spatial data. Here, they are applied to the statistical analysis of multigraphs, in general, and the analysis of multivariate social networks, in particular. In this paper, we show how to formulate models for multivariate social networks by considering a range of theoretical claims about social structure. We illustrate the models by developing structural models for several multivariate networks.

Humans↗

Vaccine preventable diseases and immunisations: a qualitative study of mothers' perceptions of severity, susceptibility, benefits and barriers.

This study investigated mothers' perceptions of vaccine-preventable diseases and associated vaccines in terms of perceived susceptibility, severity, benefits and barriers. A purposive sampling strategy was used to choose mothers whose only or youngest child was completely, incompletely (behind the recommended immunisation schedule) or partially (parents chose or advised not to have a specific immunisation) immunised or had no immunisations. Semi-structured interviews found that complete immunisers believed the risk of vaccines was lower than the risk from disease and that the likelihood of contracting many of these diseases was low. Incomplete immunisers perceived vaccines to be less effective in preventing disease and were often confused about which diseases the vaccines would protect against. Non-immunisers were more concerned about unknown, long-term side effects of vaccines than the diseases. Many mothers who did immunise believed that preventing diseases was not always possible and for diseases such as measles, mumps and rubella, it was not always necessary nor desirable. Vaccines were perceived as placing stress on the immune system rather than strengthening it. Important themes relating to barriers to the decision to immunise were a lack of 'balanced', detailed information and poor communication between health providers and parents. The major barrier to timely, age-appropriate immunisations was the occurrence of minor illnesses in the target child or the family. This study found that many mothers were balancing the risks of immunising with the risks of not immunising and this must be taken into account, along with factors such as difficulties in obtaining immunisations.

Australia↗

The representation of tonality and meter in children aged 7 and 9.

The aim of this study was to explore the development of the representations of tonality and meter in children. Eighty children with a mean age of 7 (Grade 2) and 9 years (Grade 4) were compared on both melodic and rhythmic discrimination and classification tasks. The findings were considered in relation to their specificity to both task and age effects. The results revealed a developmental progression in the representation of tonality that was consistent across tasks. The rhythmic results also supported the existence of a representation of meter that developed with age, however these findings were more subject to task effects. The influence of stimulus length and likeableness on subject performance was also examined. Increased length was found to assist discrimination performance particularly with tonal, nontonal, and nonmetrical stimuli. No effects of stimulus likeableness were observed in the data.

Analysis of Variance↗

Reaction to trauma: a cognitive processing model.

We integrated existing cognitive processing models of posttrauma reactions into a longitudinal model. Data were obtained after a multiple shooting in a city office block. The subject group comprised 158 office workers who were in the building at the time of the shootings. The methodology of this research was a repeated measures survey, with data collection at 4, 8, and 14 months posttrauma. Measures included the Impact of Events Scale (IES) and the Symptom Checklist-90-Revised. A path analysis was performed with the IES as an indication of cognitive processing. Intrusion and avoidance were shown to mediate between exposure to trauma and symptom development. Intrusion was also found to be negatively related to subsequent symptom levels. The findings provide provisional support for a cognitive processing model.

Adaptation, Psychological↗

Cognitive processing in post-trauma reactions: some preliminary findings.

The current study investigated a model of post-trauma reactions proposed initially by McFarlane (1988 a). Two separate data sets, one obtained following a multiple shooting and the other reported by McFarlane following a natural disaster, were examined. The findings of both studies provide support for a cognitive processing conceptualization of the development of post-trauma reactions.

Adaptation, Psychological↗