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Biomedical subjects

P Pelletier

Publications and source records attributed to P Pelletier.

13 recordsLinked to original sources
PubMed1986

Detection of IgA specific for toxoplasmosis in serum and cerebrospinal fluid using a non-enzymatic IgA-capture assay.

A non-enzymatic immuno assay was optimized for detection of immunoglobulin A in serum and cerebrospinal fluid specific in acquired and congenital toxoplasmosis. An antihuman IgA monoclonal antibody was coated onto a polystyrene to capture total IgA. Suspensions of Toxoplasma gondii were used as a visible antigen. Eight hundred specimens (sera, cord blood serum, and cerebrospinal fluid) were tested. These were collected from 300 patients with acquired toxoplasmosis and from 28 children with congenital toxoplasmosis. In acquired toxoplasmosis, the assay allowed early detection of specific IgA, with kinetics similar to those of specific IgM expression. In congenital toxoplasmosis, anti-T. gondii IgA could be detected in the neonatal period. This assay was useful for diagnosis, follow-up, and posttherapeutic evaluation of toxoplasmosis. Specific IgA was also detected in the cerebrospinal fluid of infected newborn children. This simple IgA capture assay improves serological diagnosis of acquired and congenital toxoplasmosis when used in combination with analysis of T. gondii specific IgG and IgM.

Antibodies, Monoclonal↗
PubMed1984

[A case of a well-tolerated spontaneous post partum uterine inversion].

The authors report the unusual case of spontaneous inversion of the uterus that occurred three days after a normal delivery. Clinically this was very well tolerated. There did not seem to be a constriction ring which normally occurs in there cases. The authors were therefore able to wait until it was quite safe to give the patient an anaesthetic. Manual replacement was easy bu inversion recurred immediately. A pack was therefore put inside the uterus, and the uterus closed down satisfactorily on it in the right position. When the pack removed under anaesthesia 48 hours later inversion did not recur.

Adult↗
PubMed1983

[Supraventricular tachycardia in utero. Apropos of a personal case, review of the literature].

After describing a case of early hydrops fetalis in a fetus demonstrating supraventricular tachycardia (TSVF) the authors review the literature: First they note the increase in the number of cases of TSVF published in the last few years, thanks to better means of monitoring pregnancies and to the place taken by TSVF among the different other troubles of fetal heart rhythm than can occur. The second section enumerates and analyses the pathological associations and the complications that have been observed in cases of TSVF that have been indexed. All have a poor prognosis: as far as those cases where there are faults in the rhythm which are associated with or alternate with TSVF, congestive heart failure occurs in 50% of cases, and organic heart pathological conditions in 20% of cases. 19.1% die. The third section analyses the means available for diagnosis and prognosis and the value of these means. Diagnosis rests on screening by clinical observation (careful auscultation in every pregnancy, observation of the raised height of the uterine fundus and a lessening in active fetal movements) and by monitoring. Only the ECG can confirm the diagnosis. Congestive heart failure is diagnosed by using ultrasound. A cardiac malformation should be searched for thoroughly by ultrasound. Monitoring in labour has no use as a prognostic indicator. Only repeated measurements of pH can demonstrate fetal distress in labour. The last section is concerned with management: digitalisation is strongly to be recommended before the fetus is mature. Propranolol should be reserved for resistant and severe cases: when there is no congestive heart failure a wait and see policy under strict observation can be followed. If there is congestive heart failure, caesarean section must be carried out. After delivery resuscitation with vagal stimulation is often sufficient, but when it is not digitalisation can be used and very rarely electric cardioversion is needed. Relapses are frequent and treatment must be followed for a year.

Adult↗
PubMed1983

[Prognosis for delivery in women with previous cesarean section. Apropos of 209 cases].

The authors have attempted to show the following with the help of 209 cases of delivery in women who had previously had Caesarean sections: Vaginal delivery is possible in approximately one out of every two cases, providing certain precautions have been taken and these are: Maternal morbidity rises to about 12% when a woman is delivered after a previous Caesarean section, whether the delivery is vaginal or, a repeat Caesarean. Furthermore, morbidity rises greatly after a failure of a trial of labour for which the indications should be very carefully considered. The outlook for the fetus is better after a vaginal delivery. In fact, this result seems to be allied to pathology which results from the surgical procedure itself. All the same, respiratory distress in the newborn is more frequent after Caesarean operation, which exposes the fetus to the risks of a uterine rupture and also of increased incidence of instrumental delivery following a previous Caesarean.

Apgar Score↗
PubMedDate not supplied

[New therapeutical possibility in a geriatric practice (author's transl)].

Thirty four patients whose ages ranged for 60 to 101 were treated with "tiapride" in a geriatric hospital. The patients' tolerance of the drug was excellent even the very elderly whose circulatory or respiratory state was often rather poor. The results obtained were good for the cases of acute or chronic agitation. They were satisfactory as regards a certain number of abnormal movements and some painful syndromes. However the number of these cases was too small for the results to be considered significant.

Aged↗