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P Perego

Publications and source records attributed to P Perego.

80 records · Page 5Linked to original sources
PubMed1980

[The plaster cast syndrome 2 cases of intestinal gastric emphysema].

Two clinical cases of acute gastric dilatation (Cast syndrome) in wearers of surgical corsets for kyphoscoliosis are described. One patient died in spite of surgical treatment, whereas the other responded favourably to conservative management. Fifty cases from the literature are examined. The seriousness and rapid progression of the syndrome are clear from its persistently high mortality (22%). Treatment was conservative in 70% of cases: antishock therapy, nasogastric aspiration, removal of the cast, while duodenojejunostomy was performed in the other 30%. In the two cases described, the seriousness of gastric distress due to compression of the duodenum by the aorta and mesentery was furthered evident from the observation of interstitial gastric emphysema.

Adolescent↗
PubMedDate not supplied

Role of apoptotic response in cellular resistance to cytotoxic agents.

The development of drug resistance is a major obstacle to effectiveness of chemotherapeutic treatment of human tumors with cytotoxic agents. Drug resistance is described as a multifactorial phenomenon, involving the expression of defense factors and/or detoxification mechanisms, alterations in drug-target interactions, and cellular response to specific cytotoxic lesions (in particular, DNA damage). Although the proposed mechanisms may contribute to the development of a variable degree of cellular resistance, it is possible that the cell response (i.e., DNA repair or apoptosis) following DNA damage plays a critical role in determining cellular chemosensitivity. The preclinical observations that tumor response to effective drug treatments is associated with induction of apoptosis support the possibility that a decreased susceptibility to apoptosis (apoptosis resistance) is relevant to clinical resistance. A number of molecular alterations associated with transformation and/or tumor progression may also be implicated in regulation of cell death pathways and in the development of drug resistance. There is evidence that the wild-type p53 is involved in cellular response to DNA damage, including cell cycle regulation, DNA repair, and activation of the pathway leading to apoptosis. Loss of wild-type p53 function could cause resistance to DNA-damaging agents, as a consequence of abrogation of p53-dependent apoptosis. The identification of new agents able to trigger p53-independent apoptosis and the search for biochemical modulators downstream of p53 may be of clinical relevance because many tumors are deficient in p53 function due to mutation or deletion. An overview of the resistance mechanisms is presented, with particular reference to the role of p53 mutations in clinical resistance and of apoptosis-related genes in cellular chemosensitivity.

Animals↗
PubMedDate not supplied

A case of breast angiosarcoma: diagnostic imaging and review of the literature.

Primary angiosarcoma of the breast is a rare tumor, with approximately 170 cases reported in the literature (1-3, 10, 11, 15). Reports on the imaging characteristics of these tumors have been occasional until a recent review by Liberman et al. (11). Diagnostic imaging of the masses include mammographic and ultrasound examinations (5): the imaging characteristics of the tumor can be nonspecific and sometimes heterogeneous (11). Only recently was one case evaluated with magnetic resonance imaging (11). We present the mammographic and sonographic features of a case of primary angiosarcoma of the breast with an inflammatory appearance.

Adult↗