National Centre for Adverse Reactions Monitoring report for the period 1 July, 1994 to 3 June, 1996.
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Biomedical subjects
Publications and source records attributed to P Pillans.
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Jaundice presented a major diagnostic and therapeutic problem in 6 out of 20 patients undergoing allogeneic bone marrow transplantation for severe acute aplastic anaemia or leukaemia in relapse. In the first 2 cases histological features of graft-versus-host disease were demonstrable in the skin but absent in the liver. In the 3rd case B-virus hepatitis was the most likely diagnosis, in the 4th cumulative cytotoxic chemotherapy was incriminated, and in the last 2 cases the jaundice was obstructive. These 6 cases illustrate the varied causation of jaundice in patients undergoing bone marrow transplantation, and emphasize that correct diagnosis is essential for rational management.
A case of severe chickenpox pneumonia in an adult is presented. Continuous positive airways pressure (CPAP) was applied, with good effect. The occurrence of pneumonia in chickenpox may convert this mild disease of childhood into a potentially fatal condition.