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Biomedical subjects

P Pin

Publications and source records attributed to P Pin.

8 recordsLinked to original sources
PubMed1990

The relationship of retrobulbar hematomas to vision in cynomolgus monkeys.

An experimental model has been developed to measure the effect of retrobulbar hematomas on functional vision in cynomolgus monkeys. In this model, functional vision was quantitated using flashed evoked visual potentials in five monkeys following creation of retrobulbar hematomas. In one monkey used as a control, functional vision remained impaired for 180 minutes following induction of retinal ischemia by increased intraorbital pressure. In two monkeys in which increased intraorbital pressure was relieved by anterior chamber paracentesis following 15 minutes of retinal ischemia, flashed evoked visual potential promptly returned to baseline level. In two additional monkeys in which increased intraorbital pressure was relieved following 30 minutes of retinal ischemia, flashed evoked visual potentials improved but never returned to baseline levels. This study demonstrates the usefulness of flashed evoked visual potentials in measuring functional vision in cynomolgus monkeys. This experimental model should prove useful in evaluating the effects of increased intraorbital pressure on functional vision and the effect of intervention on impaired vision due to retrobulbar hematomas. Further studies with larger numbers of animals are needed to clarify these preliminary studies and document longer-term effects of retinal ischemia secondary to retrobulbar hematomas.

Animals↗
PubMed1989

Fluctuation in grip and pinch strength among normal subjects.

Grip and pinch strength testing are commonly used to evaluate hand strength for disability ratings and to assess responses to various forms of therapy. This study determined the variations in grip and pinch strength in normal individuals. Ninety-five healthy subjects--61 women and 34 men--were examined prospectively by use of a Jamar dynamometer and a Preston pinch gauge. Grip and pinch were measured in the morning and afternoon twice a week for 3 weeks, giving a total of 12 testing periods. Mean grip strength fluctuated between 5.1 and 8.4 kg, or between 19.2% and 23.7%. Mean lateral pinch strength fluctuated between 2.6 and 3.8 pounds, or between 13.8% and 17.6%. There were no differences between the morning and afternoon values. Grip and pinch strength fluctuate over time. Repeat testing is necessary to accurately assess hand strength. Grip and pinch strength do not vary from morning to afternoon.

Adolescent↗
PubMed1989

The effect of breast implants on the radiographic detection of microcalcification and soft-tissue masses.

Current implants for breast augmentation containing silicone gel, saline, or both can totally obscure mammographic detection of microcalcifications and soft-tissue masses. To investigate the possibility of developing a more radiolucent implant, radiographs were obtained of silicone shells that contained silicone gel, saline, silicone gel and saline, polyurethane-covered silicone gel, gelatin, sunflower oil, and peanut oil. All radiographs were obtained using a Siemens Mammomat by placing the implant over an American College of Radiology mammography phantom. Results were measured by the ability to visualize or resolve the artifacts in the mammography phantom. The silicone shell alone minimally altered artifact resolution. Silicone shells filled with silicone gel, silicone gel and saline, saline alone, polyurethane-covered silicone gel, and gelatin were equal in radiodensity and completely obscured all phantom artifacts. Silicone shells filled with peanut oil and sunflower oil had equal radiodensity and allowed visualization of large microcalcifications and some soft-tissue masses. Current implants used for augmentation mammaplasty can totally obscure mammographic detection of microcalcifications and soft-tissue masses. A more radiolucent breast implant is possible, and further research is needed to define the best filler material and test its biocompatibility.

Breast↗
PubMed1988

The brown recluse spider bite.

A review of the literature confirms that the brown recluse spider bite is a common and sometimes serious clinical entity. Local and systemic manifestations are extremely variable, thus complicating management of the bite. Pathophysiological studies in laboratory animals yield conflicting results and therapeutic recommendations because of technical and species-specific differences. Standard therapies include aggressive, early debridement as well as systemic and intralesional corticosteroids; however, well-controlled clinical studies to establish their efficacy have not been performed. Variable and unpredictable patient responses to the spider bite necessitate a conservative yet vigilant position in managing these bites.

Humans↗
PubMed1988

[Fabian's spiral endoprostatic prosthesis].

This involves a supple metal prosthesis placed in the posterior urethra to relieve cervico-prostatic obstruction whilst allowing for normal function of the striate sphincter as well as satisfactory bladder drainage with normal continence. Easily inserted under local anesthesia and without morbidity, with a perfect functional result in the great majority of cases provided indications are complied with, i.e. essentially prostatic hypertrophy with retention. This prosthesis is designed for use in patients with temporary or permanent contraindications to surgery. Compliance with the very precise technique for insertion, under optical and televisual control, as well as with surgical contraindications (neurological bladder, cerebral arterial sclerosis, concomitant bladder lesion), ensures a good result. This prosthesis thus avoids the need for an indwelling catheter.

Aged↗
PubMed1984

[Incidence of isolation and antibiotic resistance of E. coli responsible for urinary infections outside hospitals, in specialized hospitals and in general hospitals].

E. coli is the agent most frequently isolated in urinary infection. In 1982, rates of E. coli isolation were 87% in outpatient laboratories, 63% in general hospitals and 41% in specialized hospitals. Susceptibility to ampicillin was less frequent in outpatients (43%) than in hospitalized patients (67%). In both, isolated strains were susceptible to the major urinary antiseptics ( furans , nalidixic acid, pipemidic acid) and even more so to aminoglycosides. Resistance to beta-lactams was compared in outpatients (1981) and general hospital patients (1982):TEM plasmid resistance was found in 72% and 57% of strains respectively. Resistance to quinolones was unremarkable for all strains studied except for one NALs PIPr phenotype strain recovered from an outpatient.

Anti-Bacterial Agents↗