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P Pinto

Publications and source records attributed to P Pinto.

46 records · Page 3Linked to original sources
PubMedDate not supplied

Factors associated with climacteric symptoms in women around menopause attending menopause clinics in Italy.

OBJECTIVE: To obtain data on correlates of climacteric symptoms in women around menopause attending menopause clinics in Italy. METHODS: Since 1997 a large cross sectional study has been conducted on the characteristics of women around menopause attending a network of first level menopause outpatient's clinics in Italy. A total of 66,501 (mean age 54.4 years) women are considered in the present paper. RESULTS: The odds ratios of moderate and severe hot flashes/night sweats were lower in more educated women and (for severe symptoms only) in women reporting regular physical activity. Depression, difficulty to sleep, forgetfulness and irritability tended to be less frequent in more educated women and (depression only) in women reporting regular physical activity. Parous women reported more frequently these symptoms. CONCLUSIONS: This large study confirms in Southern European population that low education, body mass index and low physical activity are associated with climacteric symptoms. Parous women are at greater risk of psychological symptoms.

Adult↗
PubMedDate not supplied

The development of the adrenal cortex in the rat. An immunohistochemical study.

The Inner Zone Antibody (IZAb) is a monoclonal antibody which interacts with an antigen found predominantly in rat adrenal inner cortical zones. Since its expression increases after ACTH treatment the antigen may have a role in steroidogenesis although, so far, this has not yet been fully characterised. Due to its molecular weight, it cannot be any of the known cytochrome P450 proteins. In this study we examined the expression of IZAb in male and female rats throughout their postnatal development and in aged animals. In a different set of animals, blood was collected for hormonal assays and the adrenals stained with classical methods. The staining with IZAb was clear from the first post-natal day. The zona glomerulosa which was always present at birth, was easily distinguished and unstained. The staining in the inner zone cells was fainter at birth and increased progressively until postnatal day 20. Afterwards these cells were remarkably stained at all ages. Medullary cells were also present from birth although they were generally found in clusters instead of constituting a well defined zone. Cortical cells appeared in the medullary zone at all ages after its complete development. The zona glomerulosa increased in size until approximately postnatal day 40 while the inner zones increased until day 70. The area of the cortex was significantly different between the two sexes from day 50 onwards and this was predominantly due to differences in the zona fasciculata. Corticosterone levels increased until approximately day 25 in the male rat and until day 45 in the female.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Cortex↗
PubMedDate not supplied

Peripheral motor-sensory neuropathy in membranous lipodystrophy (Nasu's disease): a case report.

A case of membranous lipodystrophy (ML) with peripheral polyneuropathy (PN) is described. A 40-year-old woman presented with dementia, multiple lytic bone lesions with typical membranous material in adipose tissues and neurophysiological and pathological findings of peripheral neuropathy. We describe the first case of ML with PN. It is interesting since nerve involvement might be an additional cause of symptoms usually attributed to bone lesions.

Adipose Tissue↗
PubMedDate not supplied

[Evaluation of the number of patients likely to require surgical treatment of hepatic metastases. Based on a series of 180 colorectal cancers].

The spontaneous prognosis of patients with hepatic metastases from colo-rectal cancer is poor in the short term: less than 10 p. cent will be alive after 2 years. Over recent years, several teams have obtained encouraging results after surgical resection of hepatic metastases. The aim of the present study was to evaluate the number of patients likely to require resection of hepatic metastases in a serie of 180 cases of colo-rectal cancer. 57 patients (30 p. cent) already had hepatic metastases at the time of the gastro-intestinal resection and only 3 underwent a simultaneous metastasectomy. In the other cases, the extent of the disease or the general condition of the patients contra-indicated a 2-stage resection. Among the 126 patients free of metastases at the time of the operation, 40 p. cent would have been excluded from hepatic resection in the event of secondary development of metastases because of the general clinical state. 75 patients were suitable for post-operative surveillance of hepatic metastases. We calculated that 20 of them might develop a hepatic metastasis without local recurrence of the colo-rectal cancer in the 2 years following the colonic resection, although of course we were unable to predict the type of metastasis or its accessibility to surgery. These figures may be useful as a guide to the development of a surveillance strategy.

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