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Biomedical subjects

P Plowman

Publications and source records attributed to P Plowman.

6 recordsLinked to original sources
PubMed2005

Biopsy-confirmed spontaneous resolution of orbital langerhans cell histiocytosis.

A 17-year-old boy presented with a left upper lid swelling, headaches and diplopia. An orbital computerized tomography (CT) scan showed a mass in the left lacrimal fossa eroding bone and extending into the temporalis fossa and intracranially. An urgent biopsy without curettage was carried out and showed Langerhans cell histiocytosis. He was otherwise well and no other lesion was found. He was therefore observed and reviewed regularly. During follow-up it was noted that the mass was reducing in size. Five months after the initial biopsy a further procedure, involving curettage and an intralesional steroid, was carried out at a tertiary referral center. Histology of the material obtained showed no remaining evidence of Langerhans cell histiocytosis. Spontaneous resolution of orbital Langerhans cell histiocytosis has been described clinically and radiologically. This is the first case of spontaneous resolution to be confirmed histologically.

Adolescent↗
PubMed2000

Organisational change from two perspectives: gender and organisational development.

By exploring two approaches to organizational change, gender and organizational development (OD), the author argues that OD is flawed since it perpetuates existing gender inequalities by failing to address them. By contrast, the gender approach brings change both for women and for men and is contextualized in a broader agenda of social transformation. Analysis of how power is gendered is the critical starting point. While gender is not disconnected from other forms of oppression--such as race and class--special attention needs to be given to gender because experience has shown it gets lost. This article seeks to contribute to breaking new ground in theory and practice in order to promote organizations that are both equitable and effective.

Africa↗
PubMed1990

4-hydroxyandrostenedione--further clinical and extended endocrine observations.

4-Hydroxyandrostenedione (4-OHA) was administered (250 mg intramuscularly 2-weekly) in a phase 2 clinical trial to 20 postmenopausal patients with advanced breast cancer, who had failed other endocrine therapy. Seven out of 18 assessable patients (39%) responded with minimal toxicity. Endocrine studies demonstrated that the drug produced significant initial falls in oestradiol and oestrone levels, but that these levels rose toward pretreatment levels as the study progressed. Sex hormone binding globulin (SHBG) levels gradually fell during the study suggesting that the drug has a minor degree of androgenic activity albeit of no clinical significance. There was a transient reduction of adrenal steroid levels, which remained however within the normal range. There were no symptoms of adrenal insufficiency.

Aged↗
PubMed1981

Human macrophage function in cancer: systemic and local changes detected by an assay for Fc receptor expression.

The activity of human peripheral blood monocytes and pulmonary alveolar macrophages was examined with a rosette assay that detects changes in Fc receptor expression. Compared with peripheral blood monocytes from normal subjects, the peripheral blood monocytes of patients with carcinoma of the lung were found to be activated in this respect. In contrast, compared with pulmonary alveolar macrophages from normal subjects, carcinomas exhibited depressed function in terms of receptor alveolar macrophages from lungs bearing primary expression. Trypsinization of macrophages to remove bound immunoglobulin indicated that this depression of receptor activity was not due to blocking of receptors by immunoglobulin or immune complexes. In an in vitro study the expression of Fc receptors by cultured macrophages was shown to be depressed by a heat-stable, low-molecular-weight material in supernatants of cultured carcinoma tissue from the lung, breast, and urinary bladder.

Humans↗