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Biomedical subjects

P Pocklington

Publications and source records attributed to P Pocklington.

6 recordsLinked to original sources
PubMed1982

Azathioprine in treatment of multiple sclerosis. Final results of a 41/2-year controlled study of its effectiveness covering 115 patients.

In an open, randomised, controlled follow-up study the effectiveness of continuous azathioprine therapy of multiple sclerosis with a dosage of 2 mg/kg/day was tested against a control group that was not treated with cytostatics. In the treated group the disease progressed less rapidly than in the untreated group. Statistically significant differences were only seen in patients having an intermittent-progressive course. The effect of azathioprine on the course was not dependent on the period or severity of illness nor on the patient's sex. In chronically progressive disease and with an intermittent disease course no influence of azathioprine was observed.

Adult↗
PubMed1980

Azathioprine in multiple sclerosis--a 3 year controlled study of its effectiveness.

The results of a prospective, long-term controlled study on the treatment of multiple sclerosis with azathioprine are reported. The effect of a daily 2 mg/kg body weight dosage on 56 randomly chosen patients with multiple sclerosis is compared with a non-treated control group of 51 randomly selected multiple sclerosis patients. The azathioprine therapy was continued in all cases for more than one year, on average for 732 days. To assess the effect of therapy, the course of the disease was followed by regular examinations evaluating the severity of the disease by use of an objective weighting-scale covering the whole range of neurological signs. The individual course of the disease within the observation period was determined by means of regression analysis. On average, the disease deteriorated less rapidly for those undergoing azathioprine therapy, this being most marked for patients who had had the disease for less than two years. For those who had been affected for longer, no significant differences in the progression of the disease could be detected. The annual relapse rate was the same for both categories.

Adult↗
PubMed1977

[Rescue helicopter services for emergency treatment at the scene of the accident (author's transl)].

During the last three years 3639 emergencies were dealt with using the rescue helicopter "Christoph 4" in Hannover. Of these, 89.3% were primary flights to the scene of the accident to give qualified first aid by a medical team. The average distance to the scene of the accident was 20.8 km with an average flight time of 8.5 min. 2688 patients were treated by the helicopter crew. 89.8% of the patients had injuries of a severity of NACA (National Commitee for Aeronautics) 3 and more. Intubation and artificial respiration was carried out on 293 occasions. Shock treatment with blood substitute was given in 1593 cases. 30 resuscitations at the scene of the accident were successful.

Adolescent↗