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Biomedical subjects

P Pollard

Publications and source records attributed to P Pollard.

16 recordsLinked to original sources

Managing a complex river catchment: a case study on the River Almond.

The River Almond catchment in the east central belt rates amongst Scotland's most polluted rivers. This paper describes how shifting forms of economic development in the catchment since the 1860s have affected river quality. A legacy of effects from past land uses has combined with the impacts associated with current land uses to present a substantial and complex management challenge. It is argued that there have been, and still are, scientific, legislative and socio-economic constraints on the abilities of managers to respond promptly to changing patterns of impacts on the river system. This response lag has tended to increase the costs of subsequent remediation, and has consequently supported a downward pressure on the quality standards that are considered 'realistic' by river managers. Conversely, advances in science, the expansion of regulatory powers and resources, and an increase in public interest in the environment has helped to clarify the extent of the management problems in the catchment, and allowed major advances in some areas of pollution management. In an attempt to overcome some of the remaining weaknesses of river management, river managers and interest groups have started to form inter-sectoral and multidisciplinary partnerships. The success of these new groupings is highly contingent, not so much on the competence of their scientific advice, but on the priority given to water protection by the land-use decision-makers involved, and the resources they are prepared to commit to funding rehabilitation.

Agriculture↗

Biliary PAH metabolites and EROD activity in flounder (Platichthys flesus) from a contaminated estuarine environment.

The present study in the Firth of Forth, Scotland, emphasises the usefulness of biliary metabolite measurements in estuarine monitoring using the flounder (Platichthys flesus). The short time scale (a few hours) of response to polycyclic aromatic hydrocarbon (PAH) exposure, allowed clearer interpretation of trends and differences between sites. Such differences and trends in the metabolite data were not as apparent from 7-ethoxyresorufin O-deethlyation (EROD) activity measurements, which were likely to have been blurred by the movements of flounder between sites. Statistical differences were not observed in EROD activity in flounder from the Firth of Forth (ANOVA, P = 0.065). The biliary metabolites showed statistical differences between the uppermost site of Longannet and Port Edgar, in the outer Firth, for both the 1-OH pyrene and 2-OH naphthalene metabolites (ANOVA, Tukeys, P = 0.012 and 0.022 respectively). There was also a significant correlation between the concentrations of all three individual metabolites (1-OH pyrene, 2-OH naphthalene, I-OH phenanthrene) and the log of the distance downstream from the major PAH input sources of Longannet power station and Grangemouth. Biliary PAH metabolites were shown to better reflect local contamination gradients than EROD activity. This is explained by the relative response times of the two biomarkers and local movements of the flounder in the estuary.

Animals↗

The influence of victim gender and sexual orientation on judgments of the victim in a depicted stranger rape.

This study investigated the impact of respondent gender, victim gender, and victim sexual orientation on judgments toward the victim of a depicted stranger rape. Respondents were required to read a scenario in which victim gender and sexual orientation varied between subjects, and to complete measures of behavioral blame, responsibility, and severity of the attack. Results revealed that male respondents made more anti-victim judgments than female respondents did. Male respondents judged gay male victims more negatively than they did other victims. Female respondents' judgments were pro-victim regardless of victim gender and victim sexual orientation. Results are discussed in relation to the feminist analysis of victim blame, and blame toward male rape victims. Implications for support services, particularly of male victims, are also considered.

Adolescent↗

Molecular evidence for a common leukaemic progenitor in acute mixed lymphoid and myeloid leukaemia.

De novo acute leukaemia presenting with a mixed lymphoid and myeloid leukaemic population has rarely been described. We have used the consensus Ig heavy chain primers and DNA isolated from these two distinct populations of cells in polymerase chain reactions. We demonstrated that both populations of cells exhibited Ig heavy chain gene rearrangements. Cloning and subsequent DNA sequencing of the amplified products showed a common V-D-J junctional nucleotide sequence. This work therefore provides the first evidence that the leukaemic cells in de novo acute leukaemia with a mixed lymphoid and myeloid population are derived from a common progenitor clone and may offer an explanation for the poor prognosis in these patients.

Adult↗

Gide in the U.S.S.R.: some observations on Comradeship.

After 1914-18, Gide emphasized the value of the Comradeship of Mankind rather than the essentially individualistic ethos to which he had been previously committed. However, while believing in the social benefits of tolerating pederasty, he still saw a person's difference from the norm as the guarantee of authenticity. Political idealism and curiosity took him to the U.S.S.R. in 1936, and on his return he criticized the inertia, ignorance, and conformism which he considered were encouraged by the Soviet state's promotion of the family unit. This essay examines how his attitude towards sexuality led him to question alleged political freedoms and to see in the Soviet oppression of minorities, including homosexuals, the denial of the revolutionary spirit.

Communism↗

The source of belief bias effects in syllogistic reasoning.

In studies of the belief bias effect in syllogistic reasoning, an interaction between logical validity and the believability of the conclusion has been found; in essence, logic has a larger effect on unbelievable than on believable conclusions. Two main explanations have been proposed for this finding. The selective scrutiny account claims that people focus on the conclusion and only engage in logical processing if this is found to be unbelievable; while the misinterpreted necessity account claims that subjects misunderstand what is meant by logical necessity and respond on the basis of believability when indeterminate syllogisms are presented. Experiments 1 and 2 compared the predictions of these two theories by examining whether the interaction would disappear if only determinate syllogisms were used. It did, thus providing strong support for the misinterpreted necessity explanation. However, the results are also consistent with a version of the mental models theory, and so Experiment 3 was carried out to compare these two explanations. The mental models theory received strong support, as it did also in the follow-up Experiments 4 and 5. It is concluded that people try to construct a mental model of the premises but, if there is a believable conclusion consistent with the first model they produce, then they fail to construct alternative models.

Adult↗

Judgements about victims and attackers in depicted rapes: a review.

This paper reviews the effects on subjects' judgements of a variety of factors that have been included in experimental depictions of rape. The focus is on attribution of responsibility or fault to the victim or attacker and related judgements, particularly regarding guilt and sanctions. Generally, females make more pro-victim judgements than do males, and people with non-traditional sex-role attitudes make more pro-victim judgements than do holders of more traditional views. Other factors covered are various victim characteristics, victim-attacker acquaintance, resistance, and victim attire and a range of behaviours prior to the attack. These are limits to generalization due to populations studied and methods used, and the observed effects of several factors are either minimal or inconsistent. However, some factors have reliable effects on judgements, which it is argued are explainable in terms of their link with traditional beliefs about women's rights and roles. Males have often been found to be more susceptible to these effects. In particular, it appears that if a female engages in any behaviour deemed to be 'incautious' that results in victimization then she may be perceived to be at fault, even though these behaviours would be 'legitimate' for males, and that prior romantic involvement with the attacker mitigates the perceived seriousness of, and may even be seen as supplying justification for, a sexual attack. The existence of these attitudes implies that rape may be tacitly condoned in many situations.

Aggression↗

The effect of set size on the interpretation of quantifiers used in rating scales.

Two studies are reported which investigated how people interpret quantifiers of amount such as are commonly used in questionnaires and rating scales. The results indicated that the interpretation of certain quantifiers and rating scales. The results indicated that the interpretation of certain quantifiers varied depending on the context in which they occurred. Low-magnitude quantifiers (e g, 'few', 'several') seemed to signify a much greater proportion when they described small set sizes than when they described relatively large ones. This means that it will be virtually impossible to find quantifiers for use in rating scales which achieve the desirable property of interval scaling. Despite this, some quantifiers are clearly more consistent in their interpretation and more appropriate to use than others, and recommendations are made as to the best ones to use in different situations.

Journal Article↗

The effect of secoverine hydrochloride on stimulated sigmoid motility: a double-blind, placebo controlled cross-over study in irritable bowel syndrome.

The effect of oral secoverine hydrochloride on neostigmine-stimulated sigmoid motility in 12 patients with irritable bowel syndrome was studied in a double-blind placebo-controlled cross-over study. Both spontaneous and stimulated motor activity were significantly reduced by the compound in comparison with placebo. The most sensitive indices were the frequency of wave activity, maximum amplitude and motility index. Two patients reported mild dizziness after secoverine.

Adolescent↗

Menopausal flushing: double-blind trial of a non-hormonal medication.

A multicentre, placebo-controlled, double-blind, cross-over study conducted in general practice on 100 patients has shown clonidine to have a statistically highly significant effect in controlling the number and the severity and duration of menopausal flushes. The relatively mild side effects and the absence of potentially harmful oestrogenic effects suggest that clonidine in the dose range 25 to 75 mug twice daily is a useful addition or alternative to the existing therapy for this common symptom of the menopause.

Adult↗