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Biomedical subjects

P Pollet

Publications and source records attributed to P Pollet.

13 recordsLinked to original sources
PubMed1991

Variation in 8-methoxypsoralen profiles during long-term psoralen plus ultraviolet A therapy and correlations between serum 8-methoxypsoralen levels and chromametric parameters.

Three serum 8-methoxypsoralen (8-MOP) kinetics tests were performed on 15 patients undergoing PUVA therapy. The first test was carried out before beginning PUVA treatment, the 2nd one at the 10th session and the 3rd test at the 20th PUVA session. Blood samples were taken every 30 min after the drug was taken and a standard meal ingestion during 3 h to determine the serum 8-MOP peak level and corresponding time. For 14 patients, UVA-induced erythema was measured with a Minolta CR 200 chromameter, 3 (before beginning PUVA treatment, just before 10th session and 48 h later) or 5 times (before beginning PUVA treatment, just before 10th session and 48 h later, just before 20th session and 48 h later). There was a wider distribution of serum 8-MOP peak levels in the 3rd test than in 2nd one and in the 2nd one than in the first one. These facts suggest a heterogeneity in 8-MOP metabolism in the 15 patients: 11 patients showed an earlier serum 8-MOP peak and an earlier appearance of the drug in blood in the 3rd and 2nd test than in the first one. For 9 of these 11 patients, serum 8-MOP peak levels were higher and higher from the first profile to the 3rd one, suggesting an inhibition of 8-MOP metabolism in time. In the remaining 4 patients, the 8-MOP peak time and the appearance of the drug in blood were delayed in the 3rd test compared with the first profile.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

Effects of slow release carbohydrates in the form of bean flakes on the evolution of hunger and satiety in man.

This study was undertaken to test the effects of plausible meals containing slow release starches in the form of bean flakes on plasma glucose and hunger in man. In a first study, volunteers consumed a hachis paramentier (shepherd's pie) containing either bean purée or potato purée. After the meal containing potato, plasma glucose levels rose sharply, peaked at 30-45 min and fell below initial levels 2 to 3 h later. With bean purée there was a low, sustained increase in blood glucose. In a second study, volunteers consumed six hachis parmentier (three with bean purée, three with potato purée, topped with spinach, ratatouille or tomatoes). Relative to potato, the bean purée delayed the return of hunger and decreased ratings for propensity to eat a tasty snack.

Adult↗
PubMedDate not supplied

Diet-induced mood changes in normal populations.

Using an 11-item questionnaire and a double-blind experimental design, changes in mood, hunger and food preference after taking caffeine (100 mg), tryptophan (500 mg), tyrosine (500 mg) or placebo, were investigated in 60 volunteers. At the end of the study, volunteers also ranked the four treatments on a sedation/stimulation scale. Caffeine significantly increased scores for wakefulness, vigor, clarity of mind, energy, feeling full of ideas, feeling full of go and feeling efficient. Caffeine was also ranked as the most stimulating treatment (p less than 0.001). Tyrosine produced no changes, while tryptophan shifted mean scores towards somnolent and lethargic, and was ranked most sedating (p less than 0.05). None of the treatments changed hunger ratings or carbohydrate/protein preference.

Adolescent↗